Mitochondrial Cannabinoid Receptors in the Brain

Project Information

MiCaBra

Grant agreement ID: 786467

DOI

10.3030/786467

Project closed

EC signature date 10 July 2018

Start date 1 November 2018

End date 31 October 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Beyond the Activity-Based Anorexia Model: Reinforcing Values of Exercise and Feeding Examined in Stressed Adolescent Male and Female Mice

Author(s): Imane Hurel, Bastien Redon, Amandine Scocard, Meryl Malezieux, Giovanni Marsicano, Francis Chaouloff
Published in: Frontiers in Pharmacology, Issue 10, 2019, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.00587

A Novel Cortical Mechanism for Top-Down Control of Water Intake

Author(s): Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Ana Covelo, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano
Published in: Current Biology, Issue 30/23, 2020, Page(s) 4789-4798.e4, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.09.011

Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

Author(s): Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, Jérôme M Baufreton, Eva Resel, Marjorie Varilh, Antonio C Pagano Zottola, Yamuna Mariani, Astrid Cannich, José A Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56811

Subcellular specificity of cannabinoid effects in striatonigral circuits

Author(s): Edgar Soria-Gomez, Antonio C. Pagano Zottola, Yamuna Mariani, Tifany Desprez, Massimo Barresi, Itziar Bonilla-del Río, Carolina Muguruza, Morgane Le Bon-Jego, Francisca Julio-Kalajzić, Robyn Flynn, Geoffrey Terral, Ignacio Fernández-Moncada, Laurie M. Robin, José F. Oliveira da Cruz, Simone Corinti, Yasmine Ould Amer, Julia Goncalves, Marjorie Varilh, Astrid Cannich, Bastien Redon, Zhe Zhao, T
Published in: Neuron, Issue 109/9, 2021, Page(s) 1513-1526.e11, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2021.03.007

Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition

Author(s): Urszula Skupio, Julia Welte, Roman Serrat, Abel Eraso-Pichot, Francisca Julio-Kalajzić, Doriane Gisquet, Astrid Cannich, Sebastien Delcasso, Isabelle Matias, Unai B. Fundazuri, Sandrine Pouvreau, Antonio C. Pagano Zottola, Gianluca Lavanco, Filippo Drago, Inigo Ruiz de Azua, Beat Lutz, Luigi Bellocchio, Arnau Busquets-Garcia, Francis Chaouloff, Giovanni Marsicano
Published in: Neuron, Issue 111, 2024, Page(s) 1887-1897.e6, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.04.001

Glucose metabolism links astroglial mitochondria to cannabinoid effects

Author(s): Daniel Jimenez-Blasco, Arnau Busquets-Garcia, Etienne Hebert-Chatelain, Roman Serrat, Carlos Vicente-Gutierrez, Christina Ioannidou, Paula Gómez-Sotres, Irene Lopez-Fabuel, Monica Resch-Beusher, Eva Resel, Dorian Arnouil, Dave Saraswat, Marjorie Varilh, Astrid Cannich, Francisca Julio-Kalajzic, Itziar Bonilla-Del Río, Angeles Almeida, Nagore Puente, Svein Achicallende, Maria-Luz Lopez-Rodriguez,
Published in: Nature, Issue 583/7817, 2020, Page(s) 603-608, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2470-y

Sex‐dependent pharmacological profiles of the synthetic cannabinoid MMB‐Fubinaca

Author(s): José F. Oliveira da Cruz, Christina Ioannidou, Antonio C. Pagano Zottola, Carolina Muguruza, Paula Gomez‐Sotres, Monica Fernandez, Luis F. Callado, Giovanni Marsicano, Arnau Busquets‐Garcia
Published in: Addiction Biology, Issue 26/3, 2021, ISSN 1355-6215
Publisher: Taylor & Francis
DOI: 10.1111/adb.12940

Cannabis and exercise: Effects of Δ9-tetrahydrocannabinol on preference and motivation for wheel-running in mice

Author(s): Imane Hurel, Carolina Muguruza, Bastien Redon, Giovanni Marsicano, Francis Chaouloff
Published in: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Issue 105, 2021, Page(s) 110117, ISSN 0278-5846
Publisher: Elsevier BV
DOI: 10.1016/j.pnpbp.2020.110117

Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice

Author(s): Paula Gómez-Sotres, Urszula Skupio, Tommaso Dalla Tor, Francisca Julio-Kalajzic, Astrid Cannich, Doriane Gisquet, Itziar Bonilla-Del Rio, Filippo Drago, Nagore Puente, Pedro Grandes, Luigi Bellocchio, Arnau Busquets-Garcia, Jaideep S. Bains, Giovanni Marsicano
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51416-4

Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory

Author(s): Jose F. Oliveira da Cruz, Arnau Busquets-Garcia, Zhe Zhao, Marjorie Varilh, Gianluca Lavanco, Luigi Bellocchio, Laurie Robin, Astrid Cannich, Francisca Julio-Kalajzić, Thierry Lesté-Lasserre, Marlène Maître, Filippo Drago, Giovanni Marsicano, Edgar Soria-Gómez
Published in: Cell Reports, Issue 32/7, 2020, Page(s) 108046, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108046

Synaptic Functions of Type-1 Cannabinoid Receptors in Inhibitory Circuits of the Anterior Piriform Cortex

Author(s): Geoffrey Terral, Marjorie Varilh, Astrid Cannich, Federico Massa, Guillaume Ferreira, Giovanni Marsicano
Published in: Neuroscience, Issue 433, 2020, Page(s) 121-131, ISSN 0306-4522
Publisher: Elsevier BV
DOI: 10.1016/j.neuroscience.2020.03.002

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

Author(s): Michelle Corkrum, Ana Covelo, Justin Lines, Luigi Bellocchio, Marc Pisansky, Kelvin Loke, Ruth Quintana, Patrick E. Rothwell, Rafael Lujan, Giovanni Marsicano, Eduardo D. Martin, Mark J. Thomas, Paulo Kofuji, Alfonso Araque
Published in: Neuron, Issue 105/6, 2020, Page(s) 1036-1047.e5, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.12.026

CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory

Author(s): Geoffrey Terral, Arnau Busquets-Garcia, Marjorie Varilh, Svein Achicallende, Astrid Cannich, Luigi Bellocchio, Itziar Bonilla-Del Río, Federico Massa, Nagore Puente, Edgar Soria-Gomez, Pedro Grandes, Guillaume Ferreira, Giovanni Marsicano
Published in: Current Biology, Issue 29/15, 2019, Page(s) 2455-2464.e5, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2019.06.041

mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability

Author(s): Wilfrid Mazier, Nicolas Saucisse, Vincent Simon, Astrid Cannich, Giovanni Marsicano, Federico Massa, Daniela Cota
Published in: Molecular Metabolism, Issue 28, 2019, Page(s) 151-159, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.08.005

Cannabinoid Control of Olfactory Processes: The Where Matters

Author(s): Geoffrey Terral, Giovanni Marsicano, Pedro Grandes, Edgar Soria-Gómez
Published in: Genes, Issue 11/4, 2020, Page(s) 431, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11040431

Cannabinoid-induced motor dysfunction via autophagy inhibition

Author(s): Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, Jerome M. Baufreton, Eva Resel, Marjorie Varilh, Antonio C. Pagano Zottola, Yamuna Mariani, Astrid Cannich, José A. Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán
Published in: Autophagy, Issue 16/12, 2020, Page(s) 2289-2291, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2020.1827560

A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice

Author(s): Ignacio Fernández-Moncada, Gianluca Lavanco, Unai B. Fundazuri, Nasrin Bollmohr, Sarah Mountadem, Tommaso Dalla Tor, Pauline Hachaguer, Francisca Julio-Kalajzic, Doriane Gisquet, Roman Serrat, Luigi Bellocchio, Astrid Cannich, Bérénice Fortunato-Marsol, Yusuke Nasu, Robert E. Campbell, Filippo Drago, Carla Cannizzaro, Guillaume Ferreira, Anne-Karine Bouzier-Sore, Luc Pellerin, Juan P. Bolaños,
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51008-2

Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration

Author(s): Roman Serrat, Ana Covelo, Vladimir Kouskoff, Sebastien Delcasso, Andrea Ruiz-Calvo, Nicolas Chenouard, Carol Stella, Corinne Blancard, Benedicte Salin, Francisca Julio-Kalajzić, Astrid Cannich, Federico Massa, Marjorie Varilh, Severine Deforges, Laurie M. Robin, Diego De Stefani, Arnau Busquets-Garcia, Frederic Gambino, Anna Beyeler, Sandrine Pouvreau, Giovanni Marsicano
Published in: Cell Reports, Issue 37, 2022, Page(s) 110133, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110133

Other (2)

Astroglial calcium transfer from endoplasmic reticulum to mitochondria determines synaptic integration

Author(s): Roman Serrat; A. Covelo; A. Covelo; Vladimir Kouskoff; S. Delcasso; S. Delcasso; A. Ruiz; A. Ruiz; Nicolas Chenouard; C. Stella; C. Stella; Corinne Blancard; Bénédicte Salin; Francisca Julio-Kalajzić; Francisca Julio-Kalajzić; Astrid Cannich; Astrid Cannich; Federico Massa; Federico Massa; Marjorie Varilh; Marjorie Varilh; S. Deforges; Laurie M. Robin; Laurie M. Robin; D. Destefani; Arnau Busq
Published in: Bioarchives, Issue 1, 2021
Publisher: Bioarchives
DOI: 10.1101/2020.12.08.415620

Top-down control of water intake by the endocannabinoid system

Author(s): Zhe Zhao; Zhe Zhao; Edgar Soria-Gómez; Edgar Soria-Gómez; Edgar Soria-Gómez; Marjorie Varilh; Marjorie Varilh; Francisca Julio-Kalajzić; Francisca Julio-Kalajzić; Astrid Cannich; Astrid Cannich; Adriana Castiglione; Adriana Castiglione; Léonie Vanhoutte; Léonie Vanhoutte; Alexia Duveau; Alexia Duveau; Philippe Zizzari; Philippe Zizzari; Anna Beyeler; Anna Beyeler; Daniela Cota; Daniela Cota
Published in: Bioarchives, Issue 1, 2019
Publisher: BioArchives
DOI: 10.1101/729970

Intellectual Property Rights

Patent (4)

3BÉTA-(BENZYLOXY)-17ALPHA-METHYL-PREGN-5-EN-20-ONE FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS

Application/Publication number: 18 306716
Date: 2018-12-18
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

3BETA-(4-METHOXYBENZYLOXY)PREGN-5-EN-20-ONE FOR USE IN THE TREATMENT OF CANNABINOIDS-RELATED DISORDERS

Application/Publication number: 19 705190
Date: 2019-02-20
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

3BETA-(4-METHOXYBENZYLOXY)PREGN-5-EN-20-ONE FOR USE IN THE TREATMENT OF CANNABINOIDS-RELATED DISORDERS

Application/Publication number: 19 705190
Date: 2019-02-20
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

3BÉTA-(BENZYLOXY)-17ALPHA-METHYL-PREGN-5-EN-20-ONE FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS

Application/Publication number: 18 306716
Date: 2018-12-18
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE