Mechanisms to emerge and replicate the first sequence information of life in geothermal microfluidics of early Earth

Project Information

EvoTrap

Grant agreement ID: 787356

DOI 10.3030/787356

Project closed

EC signature date 6 July 2018

Start date 1 October 2018

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 364 500,00

EU contribution € 2 364 500,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

Publications

Peer reviewed articles (22)

RNA Oligomerisation without Added Catalyst from 2′,3′‐Cyclic Nucleotides by Drying at Air‐Water Interfaces**

Author(s): Avinash Vicholous Dass; Sreekar Wunnava; Juliette Langlais; Beatriz von der Esch; Maik Krusche; Lennard Ufer; Nico Chrisam; Romeo C. A. Dubini; Florian Gartner; Severin Angerpointner; Christina F. Dirscherl; Petra Rovó; Christof B. Mast; Judit E. Šponer; Christian Ochsenfeld; Erwin Frey; Dieter Braun
Published in: Crossref, Issue 2, 2022, ISSN 2191-1363
Publisher: Wiley
DOI: 10.1002/syst.202200026

Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection.

Author(s): Patrick W. Kudella; Patrick W. Kudella; Katharina Preißinger; Matthias Morasch; Christina F. Dirscherl; Dieter Braun; Achim Wixforth; Achim Wixforth; Christoph Westerhausen; Christoph Westerhausen
Published in: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019), Issue 2, 2019, Page(s) 1-11, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-55110-0

Sequence self-selection by cyclic phase separation

Author(s): Giacomo Bartolucci, Adriana Calaça Serrão, Philipp Schwintek, Alexandra Kühnlein, Yash Rana, Philipp Janto, Dorothea Hofer, Christof B. Mast, Dieter Braun, Christoph A. Weber
Published in: PNAS, Issue 43, 2023, Page(s) 120, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2218876120

Acid-Catalyzed RNA Oligomerization from 3’,5’-cGMP

Author(s): Sreekar Wunnava; Christina F. Dirscherl; Jakub Výravský; Aleš Kovařík; Roman Matyášek; Jiří Šponer; Dieter Braun; Judit E. Šponer
Published in: Chemistry a European Journal, Issue 1, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103672

tRNA sequences can assemble into a replicator

Author(s): Alexandra Kühnlein, Simon A Lanzmich, Dieter Braun
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.63431

Prebiotic Foam Environments to Oligomerize and Accumulate RNA.

Author(s): Emre Tekin; Annalena Salditt; Philipp Schwintek; Sreekar Wunnava; Juliette Langlais; James Saenz; Dora Tang; Petra Schwille; Christof Mast; Dieter Braun
Published in: Crossref, Issue 2, 2022, ISSN 2191-1363
Publisher: Wiley
DOI: 10.1002/cbic.202200423

tRNA sequences can assemble into a replicator.

Author(s): Alexandra Kühnlein; Simon A. Lanzmich; Dieter Braun
Published in: elife, Issue 5, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.63431

Continuous nonenzymatic cross-replication of DNA strands with in situ activated DNA oligonucleotides.

Author(s): Edeleva, Evgeniia; Salditt, Annalena; Stamp, Julian; Schwintek, Philipp; Boekhoven, Job; Braun, Dieter
Published in: Chemical Science, Issue 1, 2019, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc00770a

Ligation of random oligomers leads to emergence of autocatalytic sequence network

Author(s): Patrick W. Kudella; Alexei V. Tkachenko; Sergei Maslov; Dieter Braun
Published in: PNAS, Issue 1, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1101/2020.08.18.253963

Kinetic Microscale Thermophoresis for Simultaneous Measurement of Binding Affinity and Kinetics

Author(s): Julian A. C. Stein, Alan Ianeselli, Dieter Braun
Published in: Angewandte Chemie, 2021, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202101261

Cooperative Ligation Breaks Sequence Symmetry and Stabilizes Early Molecular Replication

Author(s): Shoichi Toyabe, Dieter Braun
Published in: Physical Review X, Issue 9/1, 2019, ISSN 2160-3308
Publisher: American Physical Society
DOI: 10.1103/physrevx.9.011056

Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection

Author(s): Patrick W. Kudella, Katharina Preißinger, Matthias Morasch, Christina F. Dirscherl, Dieter Braun, Achim Wixforth, Christoph Westerhausen
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-55110-0

Periodic Melting of Oligonucleotides by Oscillating Salt Concentrations Triggered by Microscale Water Cycles Inside Heated Rock Pores

Author(s): Alan Ianeselli, Christof B. Mast, Dieter Braun
Published in: Angewandte Chemie, Issue 131/37, 2019, Page(s) 13289-13294, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201907909

Continuous nonenzymatic cross-replication of DNA strands with in situ activated DNA oligonucleotides

Author(s): Evgeniia Edeleva, Annalena Salditt, Julian Stamp, Philipp Schwintek, Job Boekhoven, Dieter Braun
Published in: Chemical Science, Issue 10/22, 2019, Page(s) 5807-5814, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc00770a

Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules

Author(s): Matthias Morasch, Jonathan Liu, Christina F. Dirscherl, Alan Ianeselli, Alexandra Kühnlein, Kristian Le Vay, Philipp Schwintek, Saidul Islam, Mérina K. Corpinot, Bettina Scheu, Donald B. Dingwell, Petra Schwille, Hannes Mutschler, Matthew W. Powner, Christof B. Mast, Dieter Braun
Published in: Nature Chemistry, Issue 11/9, 2019, Page(s) 779-788, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-019-0299-5

Kinetic microscale thermophoresis

Author(s): Stein, Julian A. C.; Ianeselli, Alan; Braun, Dieter
Published in: Angewandte Chemie, Issue 1, 2021, ISSN 1521-3757
Publisher: Gesellschaft_Deutscher_Chemiker
DOI: 10.1002/anie.202101261

Thermal Habitat for RNA Amplification and Accumulation

Author(s): Annalena Salditt, Lorenz M. R. Keil, David P. Horning, Christof B. Mast, Gerald F. Joyce, Dieter Braun
Published in: Physical Review Letters, Issue 125/4, 2020, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.125.048104

CO 2 reduction driven by a pH gradient

Author(s): Reuben Hudson, Ruvan de Graaf, Mari Strandoo Rodin, Aya Ohno, Nick Lane, Shawn E. McGlynn, Yoichi M. A. Yamada, Ryuhei Nakamura, Laura M. Barge, Dieter Braun, Victor Sojo
Published in: Proceedings of the National Academy of Sciences, Issue 117/37, 2020, Page(s) 22873-22879, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2002659117

Thermophoresis beyond Local Thermodynamic Equilibrium

Author(s): Daniel B. Mayer; Thomas Franosch; Christof Mast; Dieter Braun
Published in: Crossref, Issue 2, 2023, ISSN 1079-7114
Publisher: APS
DOI: 10.1103/physrevlett.130.168202

Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells

Author(s): Alan Ianeselli; Damla Tetiker; Julian Alexander Cornelius Stein; Alexandra Kuehnlein; Christof B. Mast; Dieter Braun; T-Y Dora Tang
Published in: Nature Chemistry, Issue 1, 2022, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1101/2021.07.08.451414

Structured sequences emerge from random pool when replicated by templated ligation

Author(s): Patrick W. Kudella, Alexei V. Tkachenko, Annalena Salditt, Sergei Maslov, Dieter Braun
Published in: Proceedings of the National Academy of Sciences, Issue 118/8, 2021, Page(s) e2018830118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2018830118

Self-Assembly of Informational Polymers by Templated Ligation

Author(s): Joachim H. Rosenberger; Tobias Göppel; Patrick W. Kudella; Dieter Braun; Ulrich Gerland; Bernhard Altaner
Published in: Physical Review X, Vol 11, Iss 3, p 031055 (2021), Issue 1, 2021, ISSN 2160-3308
Publisher: American Physical Society
DOI: 10.1103/physrevx.11.031055