Mechanisms to emerge and replicate the first sequence information of life in geothermal microfluidics of early Earth

Informazioni relative al progetto

EvoTrap

ID dell’accordo di sovvenzione: 787356

DOI 10.3030/787356

Progetto chiuso

Data della firma CE 6 Luglio 2018

Data di avvio 1 Ottobre 2018

Data di completamento 30 Settembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 364 500,00

Contributo UE € 2 364 500,00

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

Pubblicazioni

Peer reviewed articles (22)

RNA Oligomerisation without Added Catalyst from 2′,3′‐Cyclic Nucleotides by Drying at Air‐Water Interfaces**

Autori: Avinash Vicholous Dass; Sreekar Wunnava; Juliette Langlais; Beatriz von der Esch; Maik Krusche; Lennard Ufer; Nico Chrisam; Romeo C. A. Dubini; Florian Gartner; Severin Angerpointner; Christina F. Dirscherl; Petra Rovó; Christof B. Mast; Judit E. Šponer; Christian Ochsenfeld; Erwin Frey; Dieter Braun
Pubblicato in: Crossref, Numero 2, 2022, ISSN 2191-1363
Editore: Wiley
DOI: 10.1002/syst.202200026

Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection.

Autori: Patrick W. Kudella; Patrick W. Kudella; Katharina Preißinger; Matthias Morasch; Christina F. Dirscherl; Dieter Braun; Achim Wixforth; Achim Wixforth; Christoph Westerhausen; Christoph Westerhausen
Pubblicato in: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019), Numero 2, 2019, Pagina/e 1-11, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-55110-0

Sequence self-selection by cyclic phase separation

Autori: Giacomo Bartolucci, Adriana Calaça Serrão, Philipp Schwintek, Alexandra Kühnlein, Yash Rana, Philipp Janto, Dorothea Hofer, Christof B. Mast, Dieter Braun, Christoph A. Weber
Pubblicato in: PNAS, Numero 43, 2023, Pagina/e 120, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2218876120

Acid-Catalyzed RNA Oligomerization from 3’,5’-cGMP

Autori: Sreekar Wunnava; Christina F. Dirscherl; Jakub Výravský; Aleš Kovařík; Roman Matyášek; Jiří Šponer; Dieter Braun; Judit E. Šponer
Pubblicato in: Chemistry a European Journal, Numero 1, 2021, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103672

tRNA sequences can assemble into a replicator

Autori: Alexandra Kühnlein, Simon A Lanzmich, Dieter Braun
Pubblicato in: eLife, Numero 10, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.63431

Prebiotic Foam Environments to Oligomerize and Accumulate RNA.

Autori: Emre Tekin; Annalena Salditt; Philipp Schwintek; Sreekar Wunnava; Juliette Langlais; James Saenz; Dora Tang; Petra Schwille; Christof Mast; Dieter Braun
Pubblicato in: Crossref, Numero 2, 2022, ISSN 2191-1363
Editore: Wiley
DOI: 10.1002/cbic.202200423

tRNA sequences can assemble into a replicator.

Autori: Alexandra Kühnlein; Simon A. Lanzmich; Dieter Braun
Pubblicato in: elife, Numero 5, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.63431

Continuous nonenzymatic cross-replication of DNA strands with in situ activated DNA oligonucleotides.

Autori: Edeleva, Evgeniia; Salditt, Annalena; Stamp, Julian; Schwintek, Philipp; Boekhoven, Job; Braun, Dieter
Pubblicato in: Chemical Science, Numero 1, 2019, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sc00770a

Ligation of random oligomers leads to emergence of autocatalytic sequence network

Autori: Patrick W. Kudella; Alexei V. Tkachenko; Sergei Maslov; Dieter Braun
Pubblicato in: PNAS, Numero 1, 2021, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1101/2020.08.18.253963

Kinetic Microscale Thermophoresis for Simultaneous Measurement of Binding Affinity and Kinetics

Autori: Julian A. C. Stein, Alan Ianeselli, Dieter Braun
Pubblicato in: Angewandte Chemie, 2021, ISSN 0044-8249
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202101261

Cooperative Ligation Breaks Sequence Symmetry and Stabilizes Early Molecular Replication

Autori: Shoichi Toyabe, Dieter Braun
Pubblicato in: Physical Review X, Numero 9/1, 2019, ISSN 2160-3308
Editore: American Physical Society
DOI: 10.1103/physrevx.9.011056

Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection

Autori: Patrick W. Kudella, Katharina Preißinger, Matthias Morasch, Christina F. Dirscherl, Dieter Braun, Achim Wixforth, Christoph Westerhausen
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-55110-0

Periodic Melting of Oligonucleotides by Oscillating Salt Concentrations Triggered by Microscale Water Cycles Inside Heated Rock Pores

Autori: Alan Ianeselli, Christof B. Mast, Dieter Braun
Pubblicato in: Angewandte Chemie, Numero 131/37, 2019, Pagina/e 13289-13294, ISSN 0044-8249
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201907909

Continuous nonenzymatic cross-replication of DNA strands with in situ activated DNA oligonucleotides

Autori: Evgeniia Edeleva, Annalena Salditt, Julian Stamp, Philipp Schwintek, Job Boekhoven, Dieter Braun
Pubblicato in: Chemical Science, Numero 10/22, 2019, Pagina/e 5807-5814, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sc00770a

Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules

Autori: Matthias Morasch, Jonathan Liu, Christina F. Dirscherl, Alan Ianeselli, Alexandra Kühnlein, Kristian Le Vay, Philipp Schwintek, Saidul Islam, Mérina K. Corpinot, Bettina Scheu, Donald B. Dingwell, Petra Schwille, Hannes Mutschler, Matthew W. Powner, Christof B. Mast, Dieter Braun
Pubblicato in: Nature Chemistry, Numero 11/9, 2019, Pagina/e 779-788, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-019-0299-5

Kinetic microscale thermophoresis

Autori: Stein, Julian A. C.; Ianeselli, Alan; Braun, Dieter
Pubblicato in: Angewandte Chemie, Numero 1, 2021, ISSN 1521-3757
Editore: Gesellschaft_Deutscher_Chemiker
DOI: 10.1002/anie.202101261

Thermal Habitat for RNA Amplification and Accumulation

Autori: Annalena Salditt, Lorenz M. R. Keil, David P. Horning, Christof B. Mast, Gerald F. Joyce, Dieter Braun
Pubblicato in: Physical Review Letters, Numero 125/4, 2020, ISSN 0031-9007
Editore: American Physical Society
DOI: 10.1103/physrevlett.125.048104

CO 2 reduction driven by a pH gradient

Autori: Reuben Hudson, Ruvan de Graaf, Mari Strandoo Rodin, Aya Ohno, Nick Lane, Shawn E. McGlynn, Yoichi M. A. Yamada, Ryuhei Nakamura, Laura M. Barge, Dieter Braun, Victor Sojo
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/37, 2020, Pagina/e 22873-22879, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2002659117

Thermophoresis beyond Local Thermodynamic Equilibrium

Autori: Daniel B. Mayer; Thomas Franosch; Christof Mast; Dieter Braun
Pubblicato in: Crossref, Numero 2, 2023, ISSN 1079-7114
Editore: APS
DOI: 10.1103/physrevlett.130.168202

Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells

Autori: Alan Ianeselli; Damla Tetiker; Julian Alexander Cornelius Stein; Alexandra Kuehnlein; Christof B. Mast; Dieter Braun; T-Y Dora Tang
Pubblicato in: Nature Chemistry, Numero 1, 2022, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1101/2021.07.08.451414

Structured sequences emerge from random pool when replicated by templated ligation

Autori: Patrick W. Kudella, Alexei V. Tkachenko, Annalena Salditt, Sergei Maslov, Dieter Braun
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118/8, 2021, Pagina/e e2018830118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2018830118

Self-Assembly of Informational Polymers by Templated Ligation

Autori: Joachim H. Rosenberger; Tobias Göppel; Patrick W. Kudella; Dieter Braun; Ulrich Gerland; Bernhard Altaner
Pubblicato in: Physical Review X, Vol 11, Iss 3, p 031055 (2021), Numero 1, 2021, ISSN 2160-3308
Editore: American Physical Society
DOI: 10.1103/physrevx.11.031055