Senescence therapy for cancer

Project Information

SENCAN

Grant agreement ID: 787925

DOI

10.3030/787925

Project closed

EC signature date 9 July 2018

Start date 1 October 2018

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 478 750,00

EU contribution

€ 2 478 750,00

Coordinated by

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis

Author(s): Liqin Wang, Haojie Jin, Fleur Jochems, Siying Wang, Cor Lieftink, Isabel Mora Martinez, Giulia De Conti, Finn Edwards, Rodrigo Leite de Oliveira, Arnout Schepers, Yangyang Zhou, Jiaojiao Zheng, Wei Wu, Xingling Zheng, Shengxian Yuan, Jing Ling, Kathy Jastrzebski, Matheus Dos Santos Dias, Ji-Ying Song, Patrick N. H. Celie, Hideo Yagita, Ming Yao, Weiping Zhou, Roderick L. Beijersbergen, Wenxin Qin,
Published in: Nature Cancer, Issue 3, 2022, Page(s) 1284-1299, ISSN 2662-1347
Publisher: Nature publishing group
DOI: 10.1038/s43018-022-00462-2

Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen

Author(s): Arnout Schepers, Fleur Jochems, Cor Lieftink, Liqin Wang, Ziva Pogacar, Rodrigo Leite de Oliveira, Giulia De Conti, Roderick L. Beijersbergen, Rene Bernards
Published in: Molecular Cancer Research, Issue 19, 2022, Page(s) 1613-1621, ISSN 1541-7786
Publisher: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-21-0146

The Cancer Senescopedia – Delineation of Cancer Cell Senescence

Author(s): Fleur Jochems, Bram Thijssen, Robin Janssen, Giulia De Conti, Ziva Pogacar, Liqin Wang, Arnout Schepers, Cun Wang, Haojie Jin, Roderick Beijersbergen, Rodrigo Leite de Oliveira, Lodewyk Wessels, Rene Bernards
Published in: SSRN Electronic Journal, 2021, ISSN 1556-5068
Publisher: Elsevier
DOI: 10.2139/ssrn.3762763

Inducing and exploiting vulnerabilities for the treatment of liver cancer

Author(s): Cun Wang, Serena Vegna, Haojie Jin, Bente Benedict, Cor Lieftink, Christel Ramirez, Rodrigo Leite de Oliveira, Ben Morris, Jules Gadiot, Wei Wang, Aimée du Chatinier, Liqin Wang, Dongmei Gao, Bastiaan Evers, Guangzhi Jin, Zheng Xue, Arnout Schepers, Fleur Jochems, Antonio Mulero Sanchez, Sara Mainardi, Hein te Riele, Roderick L. Beijersbergen, Wenxin Qin, Leila Akkari, René Bernards
Published in: Nature, Issue 574/7777, 2019, Page(s) 268-272, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1607-3

Thinking Differently about Cancer Treatment Regimens

Author(s): Jeff Settleman, João M. Fernandes Neto, René Bernards
Published in: Cancer Discovery, Issue 11, 2022, Page(s) 1016-1023, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-1187

Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer

Author(s): Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang
Published in: Genome Medicine, Issue 13, 2021, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-021-00981-0