Cardiac REgeneration from within

Project Information

CuRE

Grant agreement ID: 787971

DOI

10.3030/787971

Project closed

EC signature date 28 November 2018

Start date 1 January 2019

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 428 492,00

EU contribution

€ 2 428 492,00

Coordinated by

KING'S COLLEGE LONDON
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

Author(s): Khatia Gabisonia, Giulia Prosdocimo, Giovanni Donato Aquaro, Lucia Carlucci, Lorena Zentilin, Ilaria Secco, Hashim Ali, Luca Braga, Nikoloz Gorgodze, Fabio Bernini, Silvia Burchielli, Chiara Collesi, Lorenzo Zandonà, Gianfranco Sinagra, Marcello Piacenti, Serena Zacchigna, Rossana Bussani, Fabio A. Recchia, Mauro Giacca
Published in: Nature, Issue 569/7756, 2019, Page(s) 418-422, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1191-6

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

Author(s): Luca Braga, Hashim Ali, Ilaria Secco, Elena Chiavacci, Guilherme Neves, Daniel Goldhill, Rebecca Penn, Jose M. Jimenez-Guardeño, Ana M. Ortega-Prieto, Rossana Bussani, Antonio Cannatà, Giorgia Rizzari, Chiara Collesi, Edoardo Schneider, Daniele Arosio, Ajay M. Shah, Wendy S. Barclay, Michael H. Malim, Juan Burrone, Mauro Giacca
Published in: Nature, Issue 594/7861, 2021, Page(s) 88-93, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03491-6

Small non-coding RNA therapeutics for cardiovascular disease

Author(s): Ajay M Shah, Mauro Giacca
Published in: European Heart Journal, Issue 43, 2022, Page(s) 4548-4561, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac463

Identification of FDA-approved drugs that induce heart regeneration in mammals

Author(s): Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen, Yuji Nakada, Ching-Cheng Hsu, Ayman Farag, Nicholas T. Lam, Ping Wang, Suwannee Thet, Ivan Menendez-Montes, Waleed M. Elhelaly, Xi Lou, Ilaria Secco, Mateusz Tomczyk, Lorena Zentilin, Jimin Pei, Miao Cui, Matthieu Dos Santos, Xiaoye Liu, Yan Liu, David Zaha, Gregory Walcott, Diana R. Tomchick, Chao Xing, Cheng Cheng Zhang, Nick V. Grishin, Mauro Giacca,
Published in: Nature Cardiovascular Research, Issue 3, 2024, Page(s) 372-388, ISSN 2731-0590
Publisher: Nature Publishing Group
DOI: 10.1038/s44161-024-00450-y

Endothelial cell–cardiomyocyte crosstalk in heart development and disease

Author(s): Andrea Colliva, Luca Braga, Mauro Giacca, Serena Zacchigna
Published in: The Journal of Physiology, Issue 598/14, 2020, Page(s) 2923-2939, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp276758

Non-coding RNA therapeutics for cardiac regeneration

Author(s): Luca Braga, Hashim Ali, Ilaria Secco, Mauro Giacca
Published in: Cardiovascular Research, 2020, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvaa071

Cardiac regeneration and remodelling of the cardiomyocyte cytoarchitecture

Author(s): Hashim Ali, Luca Braga, Mauro Giacca
Published in: The FEBS Journal, Issue 287/3, 2020, Page(s) 417-438, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15146

The pathological maelstrom of COVID-19 and cardiovascular disease

Author(s): Mauro Giacca, Ajay M. Shah
Published in: Nature Cardiovascular Research, Issue 1, 2022, Page(s) 200-210, ISSN 2731-0590
Publisher: Nature Publishing Group
DOI: 10.1038/s44161-022-00029-5

VEGF-B Gene Therapy for the Heart: Proceed with Caution

Author(s): Mauro Giacca, Fabio A. Recchia
Published in: Molecular Therapy, Issue 28/7, 2020, Page(s) 1566-1568, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.06.014

Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology

Author(s): Rossana Bussani, Edoardo Schneider, Lorena Zentilin, Chiara Collesi, Hashim Ali, Luca Braga, Maria Concetta Volpe, Andrea Colliva, Fabrizio Zanconati, Giorgio Berlot, Furio Silvestri, Serena Zacchigna, Mauro Giacca
Published in: EBioMedicine, Issue 61, 2020, Page(s) 103104, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2020.103104

Cardiac Regeneration After Myocardial Infarction: an Approachable Goal

Author(s): Mauro Giacca
Published in: Current Cardiology Reports, Issue 22/10, 2020, ISSN 1523-3782
Publisher: Current Science Inc.
DOI: 10.1007/s11886-020-01361-7

Gene Therapy for the Heart Lessons Learned and Future Perspectives

Author(s): Antonio Cannatà, Hashim Ali, Gianfranco Sinagra, Mauro Giacca
Published in: Circulation Research, Issue 126/10, 2020, Page(s) 1394-1414, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.315855

Fulfilling the Promise of RNA Therapies for Cardiac Repair and Regeneration

Author(s): Mauro Giacca
Published in: Stem Cells Translational Medicine, Issue 12, 2023, Page(s) 527-535, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1093/stcltm/szad038

Regulation of endogenous cardiomyocyte proliferation: The known unknowns

Author(s): Ilaria Secco, Mauro Giacca
Published in: Journal of Molecular and Cellular Cardiology, Issue 179, 2023, Page(s) 80-89, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2023.04.001

Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation

Author(s): Consuelo Torrini, Ryan John Cubero, Ellen Dirkx, Luca Braga, Hashim Ali, Giulia Prosdocimo, Maria Ines Gutierrez, Chiara Collesi, Danilo Licastro, Lorena Zentilin, Miguel Mano, Serena Zacchigna, Michele Vendruscolo, Matteo Marsili, Areejit Samal, Mauro Giacca
Published in: Cell Reports, Issue 27/9, 2019, Page(s) 2759-2771.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.05.005

Antagonism of miRNA in heart failure: first evidence in human

Author(s): Andrew H Baker, Mauro Giacca
Published in: European Heart Journal, Issue 42/2, 2020, Page(s) 189-191, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehaa967

Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice

Author(s): Ilaria Secco, Ana Backovic, Mateusz Tomczyk, Antonio Mura, Gang Li, Francesca Bortolotti, Simone Vodret, Matteo Dal Ferro, Elena Chiavacci, Lorena Zentilin, Gianfranco Sinagra, Serena Zacchigna, Miguel Mano, Mauro Giacca
Published in: Nature Cardiovascular Research, Issue 4, 2025, Page(s) 397-411, ISSN 2731-0590
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44161-025-00623-3

RNA interference therapeutics for cardiac regeneration

Author(s): Josef Huntington, Manendra Pachauri, Hashim Ali, Mauro Giacca
Published in: Current Opinion in Genetics & Development, Issue 70, 2021, Page(s) 48-53, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2021.05.007