Defining of human adaptive immune gene diversity and its impact on disease

Project Information

IMMUNEDIVERSITY

Grant agreement ID: 788016

DOI

10.3030/788016

Project closed

EC signature date 18 June 2018

Start date 1 December 2018

End date 30 November 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis

Author(s): Uta Hardt, Konstantin Carlberg, Erik af Klint, Peter Sahlström, Ludvig Larsson, Annika van Vollenhoven, Susana Hernandez Machado, Lena Israelsson, Khaled Amara, Karine Chemin, Marina Korotkova, Gunilla B. Karlsson Hedestam, Anca I. Catrina, Sarah A. Teichmann, Patrik L. Ståhl, Vivianne Malmström
Published in: Scientific Reports, Issue 12, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-15293-5

Adaptive immune receptor germline gene variation

Author(s): Martin M Corcoran, Gunilla B Karlsson Hedestam
Published in: Current Opinion in Immunology, Issue 87, 2024, Page(s) 102429, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2024.102429

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies

Author(s): Pradeepa Pushparaj, Andrea Nicoletto, Daniel J. Sheward, Hrishikesh Das, Xaquin Castro Dopico, Laura Perez Vidakovics, Leo Hanke, Mark Chernyshev, Sanjana Narang, Sungyong Kim, Julian Fischbach, Simon Ekström, Gerald McInerney, B. Martin Hällberg, Ben Murrell, Martin Corcoran, Gunilla B. Karlsson Hedestam
Published in: Immunity, Issue 56, 2024, Page(s) 193-206.e7, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.005

Adaptive immune receptor genotyping using the corecount program

Author(s): Sanjana Narang, Mateusz Kaduk, Mark Chernyshev, Gunilla B. Karlsson Hedestam, Martin M. Corcoran
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2023.1125884

Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

Author(s): Martin Corcoran, Mark Chernyshev, Marco Mandolesi, Sanjana Narang, Mateusz Kaduk, Kewei Ye, Christopher Sundling, Anna Färnert, Taras Kreslavsky, Carolina Bernhardsson, Maximilian Larena, Mattias Jakobsson, Gunilla B. Karlsson Hedestam
Published in: Immunity, Issue 56, 2024, Page(s) 635-652.e6, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.01.026

Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity

Author(s): Uta Hardt, Martin M. Corcoran, Sanjana Narang, Vivianne Malmström, Leonid Padyukov, Gunilla B. Karlsson Hedestam
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2023.1073414

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

Author(s): Pradeepa Pushparaj, Andrea Nicoletto, Xaquin Castro Dopico, Daniel J. Sheward, Sungyong Kim, Simon Ekström, Ben Murrell, Martin Corcoran, Gunilla B. Karlsson Hedestam
Published in: Frontiers in Virology, Issue 3, 2023, ISSN 2673-818X
Publisher: Frontiers
DOI: 10.3389/fviro.2023.1128253