Programmable Enzymatic Synthesis of Bioactive Compounds

Project Information

ProgrES

Grant agreement ID: 788231

DOI

10.3030/788231

Project closed

EC signature date 14 May 2018

Start date 1 July 2018

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 399 831,00

EU contribution

€ 2 399 830,00

Coordinated by

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

One‐Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation**

Author(s): Max Lubberink, William Finnigan, Christian Schnepel, Christopher R. Baldwin, Nicholas J. Turner, Sabine L. Flitsch
Published in: Angewandte Chemie International Edition, Issue 61, 2023, Page(s) e202205054, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202205054

Enzymatic Late‐Stage Modifications: Better Late Than Never

Author(s): Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel
Published in: Angewandte Chemie International Edition, Issue 60/31, 2021, Page(s) 16824-16855, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202014931

Rapid Screening of Diverse Biotransformations for Enzyme Evolution

Author(s): Emily E. Kempa, James L. Galman, Fabio Parmeggiani, James R. Marshall, Julien Malassis, Clement Q. Fontenelle, Jean-Baptiste Vendeville, Bruno Linclau, Simon J. Charnock, Sabine L. Flitsch, Nicholas J. Turner, Perdita E. Barran
Published in: JACS Au, Issue 1/4, 2021, Page(s) 508-516, ISSN 2691-3704
Publisher: JACS
DOI: 10.1021/jacsau.1c00027

Biocatalytic Cascades toward Iminosugar Scaffolds Reveal Promiscuous Activity of Shikimate Dehydrogenases

Author(s): Christopher R. B. Swanson, Grayson J. Ford, Ashley P. Mattey, Léa Gourbeyre, Sabine L. Flitsch
Published in: ACS Central Science, Issue 9, 2023, Page(s) 103-108, ISSN 2374-7943
Publisher: American Chemical Society
DOI: 10.1021/acscentsci.2c01169

Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades

Author(s): Grayson J. Ford, Nico Kress, Ashley P. Mattey, Lorna J. Hepworth, Christopher R. Baldwin, James R. Marshall, Lisa S. Seibt, Min Huang, William R. Birmingham, Nicholas J. Turner, Sabine L. Flitsch
Published in: Chemical Communications, Issue 56/57, 2020, Page(s) 7949-7952, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc02976a

Engineering Biocatalysts for the C−H Activation of Fatty Acids by Ancestral Sequence Reconstruction**

Author(s): Bethan S. Jones, Connie M. Ross, Gabriel Foley, Nadiia Pozhydaieva, Joseph W. Sharratt, Nico Kress, Lisa S. Seibt, Raine E. S. Thomson, Yosephine Gumulya, Martin A. Hayes, Elizabeth M. J. Gillam, Sabine L. Flitsch
Published in: Angewandte Chemie International Edition, Issue 63, 2024, Page(s) e202314869, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202314869

Biocatalytic Oxidation in Continuous Flow for the Generation of Carbohydrate Dialdehydes

Author(s): Sebastian C. Cosgrove, Ashley P. Mattey, Michel Riese, Michael R. Chapman, William R. Birmingham, A. John Blacker, Nikil Kapur, Nicholas J. Turner, Sabine L. Flitsch
Published in: ACS Catalysis, Issue 9/12, 2019, Page(s) 11658-11662, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.9b04819

Bi‐enzymatic Conversion of Cinnamic Acids to 2‐Arylethylamines

Author(s): Nicholas J. Weise, Prasansa Thapa, Syed T. Ahmed, Rachel S. Heath, Fabio Parmeggiani, Nicholas J. Turner, Sabine L. Flitsch
Published in: ChemCatChem, Issue 12/4, 2019, Page(s) 995-998, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201902128

Regio‐ and Enantio‐selective Chemo‐enzymatic C−H‐Lactonization of Decanoic Acid to ( S )‐δ‐Decalactone

Author(s): Jack Manning, Michele Tavanti, Joanne L. Porter, Nico Kress, Sam P. De Visser, Nicholas J. Turner, Sabine L. Flitsch
Published in: Angewandte Chemie, Issue 131/17, 2019, Page(s) 5724-5727, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201901242

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades

Author(s): William Finnigan, Lorna J. Hepworth, Sabine L. Flitsch, Nicholas J. Turner
Published in: Nature Catalysis, Issue 4/2, 2021, Page(s) 98-104, ISSN 2520-1158
Publisher: Nature Journal
DOI: 10.1038/s41929-020-00556-z

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**

Author(s): Ashley P. Mattey, Grayson J. Ford, Joan Citoler, Christopher Baldwin, James R. Marshall, Ryan B. Palmer, Matthew Thompson, Nicholas J. Turner, Sebastian C. Cosgrove, Sabine L. Flitsch
Published in: Angewandte Chemie International Edition, Issue 60, 2023, Page(s) 18660-18665, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202103805

Biocatalysis

Author(s): Elizabeth L. Bell, William Finnigan, Scott P. France, Anthony P. Green, Martin A. Hayes, Lorna J. Hepworth, Sarah L. Lovelock, Haruka Niikura, Sílvia Osuna, Elvira Romero, Katherine S. Ryan, Nicholas J. Turner, Sabine L. Flitsch
Published in: Nature Reviews Methods Primers, Issue 1/1, 2021, ISSN 2662-8449
Publisher: Nature Reviews Methods Primers
DOI: 10.1038/s43586-021-00044-z