In vitro high resolution reconstitution of autophagosome nucleation and expansion catalyzed by ATG9

Project Information

ATG9_SOLVES_IT

Grant agreement ID: 788508

DOI

10.3030/788508

Project closed

EC signature date 20 April 2018

Start date 1 July 2018

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 121 055,00

EU contribution

€ 2 121 055,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Imaging ATG9A, a Multi-Spanning Membrane Protein

Author(s): Alexander R. van Vliet, Stefano De Tito, Eugenia Almacellas, Sharon A. Tooze
Published in: Journal of Visualized Experiments, Issue 196, 2024, Page(s) 1-15, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/65349

ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair

Author(s): Stefano De Tito, Eugenia Almacellas, Daniel Dai Yu, Emily Millard, Wenxin Zhang, Cecilia de Heus, Christophe Queval, Javier H. Hervás, Enrica Pellegrino, Ioanna Panagi, Ditte Fogde, Teresa L.M. Thurston, Judith Klumperman, Maximiliano Gutierrez, Sharon A. Tooze
Published in: Developmental Cell, 2025, Page(s) 1-17, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2025.05.007

ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Author(s): Alexander R. van Vliet, George N. Chiduza, Sarah L. Maslen, Valerie E. Pye, Dhira Joshi, Stefano De Tito, Harold B.J. Jefferies, Evangelos Christodoulou, Chloë Roustan, Emma Punch, Javier H. Hervás, Nicola O’Reilly, J. Mark Skehel, Peter Cherepanov, Sharon A. Tooze
Published in: Molecular Cell, 2022, ISSN 1097-4164
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.10.017

Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy

Author(s): Thomas John Mercer, Yohei Ohashi, Stefan Boeing, Harold B J Jefferies, Stefano De Tito, Helen Flynn, Shirley Tremel, Wenxin Zhang, Martina Wirth, David Frith, Ambrosius P Snijders, Roger Lee Williams, Sharon A Tooze
Published in: The EMBO Journal, 2021, ISSN 1460-2075
Publisher: The EMBO Press
DOI: 10.15252/embj.2020105985

Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

Author(s): Wenxin Zhang, Taki Nishimura, Deepanshi Gahlot, Chieko Saito, Colin Davis, Harold BJ Jefferies, Anne Schreiber, Lipi Thukral, Sharon A Tooze
Published in: eLife, Issue 12, 2023, Page(s) 1-26, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.89185

ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A

Author(s): George N. Chiduza, Acely Garza-Garcia, Eugenia Almacellas, Stefano De Tito, Valerie E Pye, Alexander R. van Vliet, Peter Cherepanov, Sharon A. Tooze
Published in: Autophagy, Issue 20, 2024, Page(s) 557-576, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2023.2275905

ATG9 Not Just an Autophagy Related Protein

Author(s): Emily Millard, Sharon A. Tooze
Published in: Journal of Molecular Biology, Issue in press, 2025, Page(s) 169288, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2025.169288

Non-peer reviewed articles (1)

The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics

Author(s): Thomas J. Mercer, Sharon A. Tooze
Published in: Autophagy, 2021, Page(s) 1-3, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2021.1968615