Selective Hydrogenation of Arenes - A Dream Reaction

Project Information

HyDream

Grant agreement ID: 788558

DOI

10.3030/788558

Project closed

EC signature date 25 July 2018

Start date 1 October 2018

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 495 000,00

EU contribution

€ 2 495 000,00

Coordinated by

UNIVERSITAET MUENSTER
Germany

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Publications

Peer reviewed articles (22)

Photochemical intermolecular dearomative cycloaddition of bicyclic azaarenes with alkenes

Author(s): Jiajia Ma, Shuming Chen, Peter Bellotti, Renyu Guo, Felix Schäfer, Arne Heusler, Xiaolong Zhang, Constantin Daniliuc, M. Kevin Brown, Kendall N. Houk, Frank Glorius
Published in: Science, Issue 371/6536, 2021, Page(s) 1338-1345, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abg0720

Asymmetric arene hydrogenation: towards sustainability and application

Author(s): Lukas Lückemeier, Marco Pierau, Frank Glorius
Published in: Chemical Society Reviews, Issue 52, 2023, Page(s) 4996-5012, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cs00329a

Ru‐NHC‐Catalyzed Asymmetric Hydrogenation of 2‐Quinolones to Chiral 3,4‐Dihydro‐2‐Quinolones

Author(s): Tianjiao Hu, Lukas Lückemeier, Constantin Daniliuc, Frank Glorius
Published in: Angewandte Chemie International Edition, Issue 60/43, 2021, Page(s) 23193-23196, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202108503

Catalytic Transfer Hydrogenation of Arenes and Heteroarenes

Author(s): Coralie Gelis, Arne Heusler, Zackaria Nairoukh, Frank Glorius
Published in: Chemistry – A European Journal, Issue 26/62, 2020, Page(s) 14090-14094, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202002777

Unveiling a key catalytic pocket for the ruthenium NHC-catalysed asymmetric heteroarene hydrogenation

Author(s): Andrea Hamza; Daniel Moock; Christoph Schlepphorst; Jacob Schneidewind; Wolfgang Baumann; Frank Glorius
Published in: Chemical science 13(4), 985-995 (2021). doi:10.1039/D1SC06409F, Issue 1, 2022, Page(s) 985-995, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.18154/rwth-2022-00668

Synthesis of Saturated N‐Heterocycles via a Catalytic Hydrogenation Cascade

Author(s): Tobias Wagener; Marco Pierau; Arne Heusler; Frank Glorius
Published in: Adv. Synth. Catal. 2022, Issue Volume 364, 2022, Page(s) in press, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202200601

Enantio‐ and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

Author(s): Daniel Moock, Tobias Wagener, Tianjiao Hu, Timothy Gallagher, Frank Glorius
Published in: Angewandte Chemie International Edition, Issue in press, 2021, Page(s) in press, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202103910

Facile access to fused 2D/3D rings via intermolecular cascade dearomative [2+2] cycloaddition/rearrangement reactions of quinolines with alkenes

Author(s): J. Ma, S. Chen, P. Bellotti, T. Wagener, C. Daniliuc, K. N. Houk, F. Glorius
Published in: Nature Catalysis, Issue 5, 2022, Page(s) 405-413, ISSN 2520-1158
Publisher: Springer Nature
DOI: 10.1038/s41929-022-00784-5

Ru-NHC-Catalyzed Asymmetric, Complete Hydrogenation of Indoles and Benzofurans: One Catalyst with Dual Function

Author(s): F. Zhang, H. S. Sasmal, C. G. Daniliuc, F. Glorius
Published in: Journal of the American Chemical Society, Issue 145 (29), 2023, Page(s) 15695-15701, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c04983

Access to Unexplored 3D Chemical Space: <i>cis</i> ‐Selective Arene Hydrogenation for the Synthesis of Saturated Cyclic Boronic Acids

Author(s): Akash Kaithal; Tobias Wagener; Peter Bellotti; Constantin G. Daniliuc; Lisa Schlichter; Frank Glorius
Published in: Angew. Chem. Int. Ed. 2022, 61(32), e202206687, Issue 14337851, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202206687

Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines

Author(s): Arne Heusler, Julian Fliege, Tobias Wagener, Frank Glorius
Published in: Angewandte Chemie International Edition, Issue 60/25, 2021, Page(s) in press, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202104115

Interrupted Pyridine Hydrogenation: Asymmetric Synthesis of δ‐Lactams

Author(s): Tobias Wagener, Lukas Lückemeier, Constantin G. Daniliuc, Frank Glorius
Published in: Angewandte Chemie International Edition, Issue 60/12, 2021, Page(s) 6425-6429, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202016771

The formation of all-cis-(multi)fluorinated piperidines by a dearomatization–hydrogenation process

Author(s): Zackaria Nairoukh, Marco Wollenburg, Christoph Schlepphorst, Klaus Bergander, Frank Glorius
Published in: Nature Chemistry, Issue 11/3, 2019, Page(s) 264-270, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-018-0197-2

Selective Arene Hydrogenation for Direct Access to Saturated Carbo- and Heterocycles

Author(s): Mario P. Wiesenfeldt, Zackaria Nairoukh, Toryn Dalton, Frank Glorius
Published in: Angewandte Chemie International Edition, Issue 58/31, 2019, Page(s) 10460-10476, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201814471

Understanding the Conformational Behavior of Fluorinated Piperidines: The Origin of the Axial‐F Preference

Author(s): Zackaria Nairoukh, Felix Strieth‐Kalthoff, Klaus Bergander, Frank Glorius
Published in: Chemistry – A European Journal, Issue 26/28, 2020, Page(s) 6141-6146, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001355

Design of Ru(II)-NHC-Diamine Precatalysts Directed by Ligand Cooperation: Applications and Mechanistic Investigations for Asymmetric Hydrogenation

Author(s): Wei Li, Tobias Wagener, Lars Hellmann, Constantin G. Daniliuc, Christian Mück-Lichtenfeld, Johannes Neugebauer, Frank Glorius
Published in: Journal of the American Chemical Society, Issue 142/15, 2020, Page(s) 7100-7107, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c00985

Technology Trends of Catalysts in Hydrogenation Reactions: A Patent Landscape Analysis

Author(s): Marius A. Stoffels, Felix J. R. Klauck, Thomas Hamadi, Frank Glorius, Jens Leker
Published in: Advanced Synthesis & Catalysis, Issue 362/6, 2020, Page(s) 1258-1274, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.201901292

Mechanistic Understanding of the Heterogeneous, Rhodium-Cyclic (Alkyl)(Amino)Carbene-Catalyzed (Fluoro-)Arene Hydrogenation

Author(s): Daniel Moock, Mario P. Wiesenfeldt, Matthias Freitag, Satoshi Muratsugu, Satoru Ikemoto, Robert Knitsch, Jacob Schneidewind, Wolfgang Baumann, Andreas H. Schäfer, Alexander Timmer, Mizuki Tada, Michael Ryan Hansen, Frank Glorius
Published in: ACS Catalysis, Issue ACS Catal. 2020, 10, 6309-6317, 2020, Page(s) 6309-6317, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.0c01074

trans -Selective and Switchable Arene Hydrogenation of Phenol Derivatives

Author(s): Marco Wollenburg, Arne Heusler, Klaus Bergander, Frank Glorius
Published in: ACS Catalysis, Issue 10/19, 2020, Page(s) 11365-11370, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.0c03423

Enantioselective hydrogenation of annulated arenes: controlled formation of multiple stereocenters in adjacent rings

Author(s): Mario P. Wiesenfeldt, Daniel Moock, Daniel Paul, Frank Glorius
Published in: Chemical Science, Issue 12/15, 2021, Page(s) 5611-5615, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc07099h

Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation

Author(s): Tobias Wagener, Arne Heusler, Zackaria Nairoukh, Klaus Bergander, Constantin G. Daniliuc, Frank Glorius
Published in: ACS Catalysis, Issue 10/20, 2020, Page(s) 12052-12057, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.0c03278

cis-Selective Hydrogenation of Aryl Germanes: A Direct Approach to Access Saturated Carbo- and Heterocyclic Germanes

Author(s): Akash Kaithal, Himadri Sekhar Sasmal, Subhabrata Dutta, Felix Schäfer, Lisa Schlichter, and Frank Glorius
Published in: Journal of the American Chemical Society, Issue 145, 2023, Page(s) 4109-4118, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c12062