DNA Replication: From Physiology to Replication Stress in Human Cancer

Project Information

REPLISTRESS

Grant agreement ID: 788681

DOI

10.3030/788681

Project closed

EC signature date 26 June 2018

Start date 1 October 2018

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 231 378,00

EU contribution

€ 2 231 378,00

Coordinated by

UNIVERSITE DE GENEVE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

High-resolution mapping of mitotic DNA synthesis under conditions of replication stress in cultured cells.

Author(s): Groelly FJ, Dagg RA, Mailler J, Halazonetis TD, Tarsounas M
Published in: STAR Protocols, Issue 4, 2023, Page(s) 101970, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2022.101970

Transcription-replication conflicts underlie sensitivity to PARP inhibitors.

Author(s): Petropoulos M, Karamichali A, Rossetti GG, Freudenmann A, Iacovino LG, Dionellis VS, Sotiriou SK, Halazonetis TD.
Published in: Nature, Issue 628, 2024, Page(s) 433-441, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-024-07217-2

In vivo DNA replication dynamics unveil aging-dependent replication stress.

Author(s): Rossetti GG, Dommann N, Karamichali A, Dionellis VS, Asensio Aldave A, Yarahmadov T, Rodriguez-Carballo E, Keogh A, Candinas D, Stroka D, Halazonetis TD
Published in: Cell, Issue 187, 2024, Page(s) 6220-6234, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.08.034

RECQL4 is not critical for firing of human DNA replication origins

Author(s): Laura Padayachy; Sotirios G. Ntallis; Thanos D. Halazonetis
Published in: Scientific Reports, Issue 14, 2024, Page(s) 7708, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-58404-0

RAD51 protects human cells from transcription-replication conflicts.

Author(s): Bhowmick R, Lerdrup M, Gadi SA, Rossetti GG, Singh MI, Liu Y, Halazonetis TD, Hickson ID.
Published in: Molecular Cell, Issue 82, 2022, Page(s) 3366-3381, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.07.010

<scp>Cdt1</scp> overexpression drives colorectal carcinogenesis through origin overlicensing and <scp>DNA</scp> damage

Author(s): Michalis Petropoulos; Spyridon Champeris Tsaniras; Sofia Nikou; Styliani Maxouri; Vasilis S Dionellis; Argyro Kalogeropoulou; Angeliki Karamichali; Konstantinos Ioannidis; Iosif‐Rodolfos Danalatos; Mandy Obst; Ronald Naumann; George J Delinasios; Vassilis G Gorgoulis; Vassilis Roukos; Konstantinos Anastassiadis; Thanos D Halazonetis; Vasiliki Bravou; Zoi Lygerou; Stavros Taraviras
Published in: Journal Pathology, Issue 259, 2022, Page(s) 10-20, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.6017

A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells.

Author(s): Dagg RA, Zonderland G, Lombardi EP, Rossetti GG, Groelly FJ, Barroso S, Tacconi EMC, Wright B, Lockstone H, Aguilera A, Halazonetis TD, Tarsounas M.
Published in: Nature Communications, Issue 12, 2021, Page(s) 4919, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25215-0

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.

Author(s): Groelly FJ, Dagg RA, Petropoulos M, Rossetti GG, Prasad B, Panagopoulos A, Paulsen T, Karamichali A, Jones SE, Ochs F, Dionellis VS, Puig Lombardi E, Miossec MJ, Lockstone H, Legube G, Blackford AN, Altmeyer M, Halazonetis TD, Tarsounas M.
Published in: Molecular Cell, Issue 82, 2022, Page(s) 3382-3397, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.07.011