Tethers for sensory mechanotransduction: from molecules to perception

Project Information

SENSATIONAL TETHERS

Grant agreement ID: 789128

DOI

10.3030/789128

Project closed

EC signature date 18 June 2018

Start date 1 July 2018

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Lack of evidence for participation of TMEM150C in sensory mechanotransduction

Author(s): Julia Ojeda-Alonso, Valérie Bégay, Jonathan Alexis Garcia-Contreras, Andrea Fernanda Campos-Pérez, Bettina Purfürst, Gary R. Lewin
Published in: Journal of General Physiology, Issue 154, 2022, ISSN 0022-1295
Publisher: Rockefeller University Press
DOI: 10.1085/jgp.202213098

Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

Author(s): Simon Desiderio, Frederick Schwaller, Kevin Tartour, Kiran Padmanabhan, Gary R Lewin, Patrick Carroll, Frederic Marmigere
Published in: eLife, Issue 12, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.89287

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility

Author(s): Elijah D. Lowenstein, Pierre-Louis Ruffault, Aristotelis Misios, Kate L. Osman, Huimin Li, Rachel S. Greenberg, Rebecca Thompson, Kun Song, Stephan Dietrich, Xun Li, Nikita Vladimirov, Andrew Woehler, Jean-François Brunet, Niccolò Zampieri, Ralf Kühn, Stephen D. Liberles, Shiqi Jia, Gary R. Lewin, Nikolaus Rajewsky, Teresa E. Lever, Carmen Birchmeier
Published in: Neuron, Issue 111, 2024, Page(s) 2184-2200.e7, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.04.025

Touch sensation requires the mechanically gated ion channel ELKIN1

Author(s): Sampurna Chakrabarti, Jasmin D. Klich, Mohammed A. Khallaf, Amy J. Hulme, Oscar Sánchez-Carranza, Zuzanna M. Baran, Alice Rossi, Angela Tzu-Lun Huang, Tobias Pohl, Raluca Fleischer, Carina Fürst, Annette Hammes, Valérie Bégay, Hanna Hörnberg, Rocio K. Finol-Urdaneta, Kate Poole, Mirella Dottori, Gary R. Lewin
Published in: Science, Issue 383, 2024, Page(s) 992-998, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adl0495

USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans

Author(s): Fred Schwaller, Valérie Bégay, Gema García-García, Francisco J. Taberner, Rabih Moshourab, Brennan McDonald, Trevor Docter, Johannes Kühnemund, Julia Ojeda-Alonso, Ricardo Paricio-Montesinos, Stefan G. Lechner, James F. A. Poulet, Jose M. Millan, Gary R. Lewin
Published in: Nature Neuroscience, Issue 24/1, 2021, Page(s) 74-81, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-00751-y

Cultural transmission of vocal dialect in the naked mole-rat

Author(s): Alison J. Barker, Grigorii Veviurko, Nigel C. Bennett, Daniel W. Hart, Lina Mograby, Gary R. Lewin
Published in: Science, Issue 371, 2024, Page(s) 503-507, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abc6588

SPFH protein cage — one ring to rule them all

Author(s): Oliver Daumke, Gary R. Lewin
Published in: Cell Research, Issue 32, 2022, Page(s) 117-118, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-021-00605-7

Piezo2 voltage-block regulates mechanical pain sensitivity

Author(s): Oscar Sánchez-Carranza, Sampurna Chakrabarti, Johannes Kühnemund, Fred Schwaller, Valérie Bégay, Jonathan Alexis García-Contreras, Lin Wang, Gary R Lewin
Published in: Brain, 2024, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awae227

Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms

Author(s): Ewan St. John Smith, Thomas J. Park, Gary R. Lewin
Published in: Journal of Comparative Physiology A, Issue 206/3, 2020, Page(s) 313-325, ISSN 0340-7594
Publisher: Springer Verlag
DOI: 10.1007/s00359-020-01414-w

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception

Author(s): Julia Ojeda-Alonso, Laura Calvo-Enrique, Ricardo Paricio-Montesinos, Rakesh Kumar, Ming-Dong Zhang, James F. A. Poulet, Patrik Ernfors, Gary R. Lewin
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-44845-8

William D. Willis, Jr, MD, PhD Memorial Lecture: The evolutionary history of nerve growth factor and nociception

Author(s): Gary R. Lewin
Published in: Pain, Issue 161/Supplement 1, 2020, Page(s) S36-S47, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000001889

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

Author(s): Swetha E. Murthy, Meaghan C. Loud, Ihab Daou, Kara L. Marshall, Frederick Schwaller, Johannes Kühnemund, Allain G. Francisco, William T. Keenan, Adrienne E. Dubin, Gary R. Lewin, Ardem Patapoutian
Published in: Science Translational Medicine, Issue 10/462, 2018, Page(s) eaat9897, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aat9897

The Sensory Coding of Warm Perception

Author(s): Ricardo Paricio-Montesinos, Frederick Schwaller, Annapoorani Udhayachandran, Florian Rau, Jan Walcher, Roberta Evangelista, Joris Vriens, Thomas Voets, James F.A. Poulet, Gary R. Lewin
Published in: Neuron, Issue 106/5, 2020, Page(s) 830-841.e3, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.02.035

TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration

Author(s): Amrutha Patkunarajah, Jeffrey H Stear, Mirko Moroni, Lioba Schroeter, Jedrzej Blaszkiewicz, Jacqueline LE Tearle, Charles D Cox, Carina Fürst, Oscar Sánchez-Carranza, María del Ángel Ocaña Fernández, Raluca Fleischer, Murat Eravci, Christoph Weise, Boris Martinac, Maté Biro, Gary R Lewin, Kate Poole
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.53308

Role of TMEM100 in mechanically insensitive nociceptor un-silencing

Author(s): Timo A. Nees, Na Wang, Pavel Adamek, Nadja Zeitzschel, Clement Verkest, Carmen La Porta, Irina Schaefer, Julie Virnich, Selin Balkaya, Vincenzo Prato, Chiara Morelli, Valerie Begay, Young Jae Lee, Anke Tappe-Theodor, Gary R. Lewin, Paul A. Heppenstall, Francisco J. Taberner, Stefan G. Lechner
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37602-w

Other (1)

TENM4 is an essential transduction component for touch and pain

Author(s): Mohammed Khallaf, Angela Tzu-Lun Huang, Letizia Dalmasso, Sampurna Chakrabarti, Rowena Groeneveld, Yinth Andrea Bernal Sierra, Jonathan Alexis Garcia Contreras, Anja Schuetz, Valerie Begay, Sarah Hedtrich, Wei Zhong, Oliver Popp, Philipp Mertins, Gary R Lewin
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.10.617546