Environment-coupled metabolic models for engineering high-temperature and drought REsistant LEAF metabolism.

Información del proyecto

Re-Leaf

Identificador del acuerdo de subvención: 789213

DOI

10.3030/789213

Proyecto finalizado el 30 Junio 2019

Fecha de la firma de la CE 14 Marzo 2018

Fecha de inicio 2 Agosto 2018

Fecha de finalización 1 Agosto 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 183 454,80

Aportación de la UE

€ 183 454,80

Coordinado por

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

Objetivo

Food security is one of the biggest challenges of our century. Climate change and an increasing human population call for
crop plants that are resistant to abiotic stresses, such as heat and drought while maintaining high productivity and nutritional
values. This will require rational strategies for metabolic engineering of crop plants. Fundamental to this engineering
challenge is the modelling of leaf metabolism. Leaves are the main site of photosynthesis and therefore the interface where
carbon from the environment is assimilated to synthesise and maintain cellular components. Plants have developed different
mechanisms to fix carbon: C3, C4, and Crassulacean Acid Metabolism (CAM). While C3 photosynthesis is the most
widespread form, the latter two exhibit higher efficiency at higher temperatures or drought, respectively. Current large-scale
metabolic models lack a mathematical description of processes on the interface between the environment and the leaf. To
address this problem, I intend to devise a computational approach that couples genome-scale metabolic modeling to the
environment by explicitly modeling gas-water exchange. These multi-layer models will help address fundamental questions
about the operation of C4 photosynthesis and CAM. The workplan comprises two research objectives: 1) Coupling CO2-
water gas exchange models with multi-timestep diel models: The CO2-water exchange models will allow changing
environmental conditions during the diel cycle (e.g. temperature and humidity cycles) to be coupled to the behavior of the
metabolic models. These environment-coupled models will be used to address the second research objective: 2) Model-driven studies of C4 and CAM metabolism: The extended diel models will be used to investigate metabolic engineering
strategies for improved productivity under high temperatures (e.g. by introducing C4) and to understand the trade-off
between productivity and water-use efficiency in both C3 and CAM plants.

Ámbito científico (EuroSciVoc)

• ingeniería y tecnología › biotecnología industrial › ingeniería metabólica
• ciencias sociales › economía y empresa › ciencia económica › economía de la producción › productividad
• ciencias médicas y de la salud › ciencias de la salud › nutrición
• ciencias naturales › ciencias de la tierra y ciencias ambientales conexas › ciencias de la atmósfera › climatología › cambios climáticos
• ciencias naturales › ciencias biológicas › botánica

Palabras clave

• metabolic modeling
• leaf metabolism
• in-silico
• C3 photosynthesis
• C4 photosynthesis
• Crassulacean
• Acid Metabolism
• heat tolerance
• drought tolerance
• Flux Balance Analysis
• biophysical model

Programa(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions PROGRAMA PRINCIPAL
  
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
  

Tema(s)

• MSCA-IF-2017 - Individual Fellowships
  

Régimen de financiación

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Convocatoria de propuestas

H2020-MSCA-IF-2017

Coordinador

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

• Aportación neta de la UEn: € 183 454,80
• Dirección: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford ; Reino Unido
• Región: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: € 183 454,80