Single cell correlates of memory, motivation and individuality

Project Information

SCCMMI

Grant agreement ID: 789274

DOI

10.3030/789274

Project closed

EC signature date 27 April 2018

Start date 1 October 2018

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 055,00

EU contribution

€ 2 499 055,00

Coordinated by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila

Author(s): Bhagyashree Senapati, Chang-Hui Tsao, Yi-An Juan, Tai-Hsiang Chiu, Chia-Lin Wu, Scott Waddell, Suewei Lin
Published in: Nature Neuroscience, Issue 22/12, 2019, Page(s) 2029-2039, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-019-0515-z

Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila

Author(s): Pedro F. Jacob, Scott Waddell
Published in: Neuron, Issue 106/6, 2020, Page(s) 977-991.e4, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.03.013

Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

Author(s): Yanying Wu, Yosuke Funato, Eleonora Meschi, Kristijan D Jovanoski, Hiroaki Miki, Scott Waddell
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61339

Input Connectivity Reveals Additional Heterogeneity of Dopaminergic Reinforcement in Drosophila

Author(s): Nils Otto, Markus W. Pleijzier, Isabel C. Morgan, Amelia J. Edmondson-Stait, Konrad J. Heinz, Ildiko Stark, Georgia Dempsey, Masayoshi Ito, Ishaan Kapoor, Joseph Hsu, Philipp M. Schlegel, Alexander S. Bates, Li Feng, Marta Costa, Kei Ito, Davi D. Bock, Gerald M. Rubin, Gregory S.X.E. Jefferis, Scott Waddell
Published in: Current Biology, Issue 30/16, 2020, Page(s) 3200-3211.e8, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.05.077

A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

Author(s): Aaron M Allen, Megan C Neville, Sebastian Birtles, Vincent Croset, Christoph Daniel Treiber, Scott Waddell, Stephen F Goodwin
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.54074

CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses

Author(s): Irmgard U. Haussmann, Yanying Wu, Mohanakarthik P. Nallasivan, Nathan Archer, Zsuzsanna Bodi, Daniel Hebenstreit, Scott Waddell, Rupert Fray, Matthias Soller
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28549-5

Transposon expression in the Drosophila brain is driven by neighboring genes and diversifies the neural transcriptome

Author(s): Christoph D Treiber, Scott Waddell
Published in: Genome Research, 2020, Page(s) gr.259200.119, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.259200.119

Prior experience conditionally inhibits the expression of new learning in Drosophila

Author(s): Pedro F. Jacob, Paola Vargas-Gutierrez, Zeynep Okray, Stefania Vietti-Michelina, Johannes Felsenberg, Scott Waddell
Published in: Current Biology, Issue 31, 2025, Page(s) 3490-3503.e3, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.05.056

Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

Author(s): Jessica Mitchell, Carlas S Smith, Josh Titlow, Nils Otto, Pieter van Velde, Martin Booth, Ilan Davis, Scott Waddell
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.62770

Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila

Author(s): Eleonora Meschi, Lucille Duquenoy, Nils Otto, Georgia Dempsey, Scott Waddell
Published in: Neuron, Issue 112, 2024, Page(s) 2315-2332.e8, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2024.04.035

Dopaminergic systems create reward seeking despite adverse consequences

Author(s): Kristijan D. Jovanoski, Lucille Duquenoy, Jessica Mitchell, Ishaan Kapoor, Christoph D. Treiber, Vincent Croset, Georgia Dempsey, Sai Parepalli, Paola Cognigni, Nils Otto, Johannes Felsenberg, Scott Waddell
Published in: Nature, Issue 623, 2023, Page(s) 356-365, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06671-8

Gliotransmission of D-serine promotes thirst-directed behaviors in <i>Drosophila</i>

Author(s): Annie Park, Vincent Croset, Nils Otto, Devika Agarwal, Christoph D. Treiber, Eleanora Meschi, David Sims, Scott Waddell
Published in: Current Biology, 2026, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1101/2022.03.07.483255

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly

Author(s): Hongjie Li, Jasper Janssens, Maxime De Waegeneer, Sai Saroja Kolluru, Kristofer Davie, Vincent Gardeux, Wouter Saelens, Fabrice P. A. David, Maria Brbić, Katina Spanier, Jure Leskovec, Colleen N. McLaughlin, Qijing Xie, Robert C. Jones, Katja Brueckner, Jiwon Shim, Sudhir Gopal Tattikota, Frank Schnorrer, Katja Rust, Todd G. Nystul, Zita Carvalho-Santos, Carlos Ribeiro, Soumitra Pal, Sharvani Mah
Published in: Science, Issue 375, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abk2432

Other (3)

Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration

Author(s): Silas A. Buck, Sophie A. Rubin, Tenzin Kunkhyen, Christoph D. Treiber, Xiangning Xue, Lief E. Fenno, Samuel J. Mabry, Varun R. Sundar, Zilu Yang, Divia Shah, Kyle D. Ketchesin, Darius D. Becker-Krail, Iaroslavna Vasylieva, Megan C. Smith, Florian J. Weisel, Wenjia Wang, M. Quincy Erickson-Oberg, Emma I. O’Leary, Eshan Aravind, Charu Ramakrishnan, Yoon Seok Kim, Yanying Wu, Matthias Quick, Jonath
Published in: bioRxiv, 2026
Publisher: openRxiv
DOI: 10.1101/2023.10.02.560584

Tango-seq: overlaying transcriptomics on connectomics to identify neurons downstream of <i>Drosophila</i> clock neurons

Author(s): Alison Ehrlich, Angelina A. Xu, Sofia Luminari, Simon Kidd, Christoph D. Treiber, Jordan Russo, Justin Blau
Published in: bioRxiv, 2026
Publisher: openRxiv
DOI: 10.1101/2024.05.22.595372

Visceral signaling of post-ingestive malaise directs memory updating in Drosophila

Author(s): Bhagyashree Senapati, Christoph D. Treiber, Scott Waddell
Published in: bioRxiv, 2026
Publisher: openRxiv
DOI: 10.1101/2025.10.21.683769

Non-peer reviewed articles (1)

Thirst increases astrocytic release and synthesis of D-serine to promote water procurement

Author(s): Scott Waddell
Published in: The Project Repository Journal, Issue 13, 2022, Page(s) 8-11, ISSN 2632-4067
Publisher: European Dissemination Media Agency Limited
DOI: 10.54050/prj1318812