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A versatile ultrafast Click platform for antibody based radio diagnostics

Objective

Diagnosing cancer as early as possible is one of the most powerful strategies in modern medicine to improve
human well-being. Antibodies (Abs) are excellent molecules that can be used to target specific tumors. As Abs
require hours to days for accumulating on tumor surfaces, the use of Abs for nuclear imaging (such as PET
imaging) is limited by the short half-lives of popular radioisotopes. Therefore, we plan to move the step of radiolabeling
from the bench to the tumor itself. However, the entanglement of Abs with an artificial chemical probe is
one of the most promising but at the same time one of the most technically challenging developmental areas in
biotechnology. Our unique approach is based on the production of “hybrid-Abs”, which combine in only one “click”
step the power of synthetic chemistry with the best of biology (“custom-biologics”). Our unique selling points are
ultra-fast, exceptional bioorthogonal and specific labeling reactions in living organism as well as a both-sided
modularity of the connection between Abs and chemical probe. By doing so, high contrast visualization of the
cancer will become possible.

Fields of science (EuroSciVoc)

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Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-POC - Proof of Concept Grant

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2017-PoC

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Host institution

JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 75 000,00
Address
SAARSTRASSE 21
55122 MAINZ
Germany

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Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 87 500,00

Beneficiaries (3)

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