Objectif HER2+ breast cancers are an aggressive type of breast cancer and have a poor prognosis. There are many therapies currently on the market to target this type of cancer, however they fail to deliver effective clinical results due to therapy resistance. In our ERC-CoG project, we found that proper endosomal trafficking is required for functional HER2 oncogenic signalling at the plasma membrane. Targeting HER2 endosomal traffic can result in effective treatment of HER2+ cancers, without the risk of therapy resistance. As such, this innovation could deliver the first truly effective cancer treatment for HER2+ breast cancer patients that do not respond to current treatments. In this ERC-PoC, we aim to prove that therapeutic targeting of endosomal traffic is effective in HER2+ cancer models in vivo, as a monotherapy and synergistically with current therapeutic antibodies, and to explore the commercial avenues to exploit this finding. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologybreast cancer Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-2017-PoC - ERC-Proof of Concept Appel à propositions ERC-2017-PoC Voir d’autres projets de cet appel Régime de financement ERC-POC - Proof of Concept Grant Institution d’accueil TURUN YLIOPISTO Contribution nette de l'UE € 150 000,00 Adresse YLIOPISTONMAKI 20014 Turku Finlande Voir sur la carte Région Manner-Suomi Etelä-Suomi Varsinais-Suomi Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 150 000,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire TURUN YLIOPISTO Finlande Contribution nette de l'UE € 150 000,00 Adresse YLIOPISTONMAKI 20014 Turku Voir sur la carte Région Manner-Suomi Etelä-Suomi Varsinais-Suomi Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 150 000,00