Project description
A novel platform for extracellular vesicle isolation
Extracellular vesicles (EVs) represent an important communication pathway between cells and deliver various molecules, such as proteins, lipids and RNA. EVs are increasingly being recognised as promising disease biomarkers, but their characterisation and purification from biological samples is challenging and time-consuming. The key objective of the EU-funded MNSWLGM project is to develop an optofluidic platform with a size selection criterion for EV identification, sorting and fractionation. The platform is expected to overcome current technological limitations in EV research and pave the way for the utilisation of EVs in clinical diagnosis.
Objective
Extracellular vesicles (EVs) describe distinct populations of small (30-200 nm) and large (500 nm-2 μm)
microvesicles actively or passively secreted by cells. Whilst, they are recognized as promising biomarkers for
diseases diagnosis, prognosis and therapy, their purification, selective enrichment, and characterization remains
immensely challenging. The goal of the current proposal is to develop an optofluidic platform able to
manipulate and characterize single EVs and facilitate their efficient purification and quantitation from
biological samples. The optofluidic platform will incorporate a dynamically reconfigurable optical lattice
(constructed from a liquid gradient refractive index - L-GRIN microlens) for separation followed by a viscoelastic
focusing module for single EV imaging. The strength of the interaction between a nanoparticle and the optical
lattice will depend on the optical polarizability of the particle, thus providing a size selection criterion to allow
identification and isolation. Put simply, we aim to develop a size-selective optofluidic platform integrated for
non-invasive EVs sorting and fractionation that can be applied to a wide range of biological matrices and
addresses the most challenging technological bottleneck in EVs research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.