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Tracking Genetic Adaptation of Populations Using Time-Series Genomic Data

Objective

The aim of this proposal is to develop statistical methods for inference of demography and adaptation from genetic data collected at several times along the history of the population. In particular, I will target genomic data obtained from human remains from archaeological sites of hunter-gatherers, early farmers and Pontic-steppe herder groups and current European populations. The originality of my proposal is to address the the joint inference of neutral and selective forces acting on populations. In order to achieve this, I will take advantage of recent advances (the use of random forests in approximate Bayesian computation) that alleviate the computational burden of these inferences. The methods developed will be relevant to the community of evolutionary biologists in general and for human evolutionary biologist and archaeologists. The results will further clarify the genetics of the Neolithic transition in Europe, particularly regarding the role of adaptation and admixture. These results will be disseminated to the scientific community in the standard way (conferences, peer-reviewed journals and software implementing the methods) and to the general public through short animated films. The main training goal of the fellowship is to acquire experience in the analysis of high throughput sequencing data in a model organism (sensu lato), gaining international experience. This will increase my chances to lead research projects and further advance my career. The Jakobsson Lab will be the ideal place to achieve all these objectives because of its expertise in theoretical population genetics, human evolutionary biology and ancient DNA.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2017

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Coordinator

UPPSALA UNIVERSITET
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 185 857,20
Address
VON KRAEMERS ALLE 4
751 05 Uppsala
Sweden

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Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 185 857,20
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