Objective
Cardiomyocytes (CMs) are the contractile cells of the heart. Their regenerative capacity is lost after birth. Embryonic stem cells (ESCs) are able to differentiate into functional CMs, however this process is not yet efficient. The elucidation of ESCs’ differentiation into CMs could provide an additional avenue for therapeutic interventions and disease modeling. This interdisciplinary project will result in a unique platform that targets precise quantification of the fundamental molecular mechanisms underlying mouse ESC cardiac differentiation at the single cell level. The platform takes the advantages of 3D tailored conductive microscaffolds (3DTCMSs) to deliver precise mechanical and electrical stimulation patterns to individual cells in vitro. Co-integrated 3DTCMSs have the necessary infrastructure for long-term cell culturing. The platform is accessible for in situ high-resolution, real-time microscopic observation of essential molecular information due to transparent materials. Advanced two-photon polymerization photolithography will be utilized for the exact reconstruction of 3DTCMSs based on a novel optically transparent, conductive ionic liquid-polymer composite. ESC pluripotent factors and CM markers will be monitored comparatively by live microscopy and molecular analysis. This project aims to integrate expertise in materials science, engineering, cellular and molecular biology. As a result, a novel in vitro CM differentiation model will be developed, which has a potential to open a completely new window of research in systems biology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering composites
- natural sciences physical sciences optics microscopy
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.