Objective
Immuno-oncology (IO) and specifically immune checkpoint inhibitors (ICIs) have recently shown significant clinical benefit in a growing number of different tumor types. However 60-90% of the patients experience immune-related adverse events (irAEs) associated with inflammatory or autoimmune responses that can affect any organ and system. Early recognition and treatment of these irAEs is crucial to reduce morbidity, organ complications and ultimately, mortality. Patient reported outcomes (PROs) result in earlier detection of symptom occurrence and severity compared to clinician reports, which tend to understate these experiences, and can serve as a reliable complementary indicator for AEs before their clinical manifestation. Although the use of PROs is highly recommended to be included as an endpoint in clinical trials, no IO-specific-PRO tool has been developed to date and the use of general cancer-specific instruments does not address the needs, concerns and specific symptoms experienced by patients undergoing ICI therapy. The overall objective of this project is therefore to gain a comprehensive understanding of patients’ experience over the immunotherapeutic treatment course based on qualitative interviews with patients, their caregivers and healthcare professionals. This will enable evaluating the need for adaptation or development of new IO-PRO measures. Furthermore, variations in immune-related biomarkers might predict the appearance and severity of symptoms and serve as surrogates for high-grade AEs risk stratification. Hence, this project will additionally investigate potential associations between symptoms and biomarkers over the treatment course in order to elucidate existing correlations. Results derived from this study will facilitate the development of more efficient and targeted care interventions based on the characteristics of the individual in the future, together advancing a patient-centered model of care in IO.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-SE - Society and Enterprise panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1011 Lausanne
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.