Objective
Ischemic stroke occurs due to reduced perfusion to a brain region, because of the blockage of a blood vessel, resulting in death or permanent neurological deficits. It presents high percentages of mortality and morbidity worldwide and market analysis in five major EU countries showed that the total number of first-ever incidents of stroke cases will rise to 1.63 million (43.7% growth) by 2034. Although, many treatments that make use of therapeutic nanoparticles have been presented, unfortunately to date, no effective treatment has been found to prevent damage to the ischemic brain after stroke. Oxidative stress is related to the pathogenesis of stroke and overproduction of ROS and RNS are thought to be the main cause of this. In addition, the overproduction of MMP-9 has been related to many post-stroke side effects. Thus, I propose the development of a biomimetic and neuroprotective lipid nanocapsule (BIONICS) for the targeted treatment of post-stroke side effects. BIONICS will safely deliver anti-oxidant nanoparticles (CeO2) and iNOS inhibitors (L-NIL) across the BBB aiming at reducing the overproduced ROS, RNS and MMP-9, resulting in to the amelioration of the neurological deficits caused by oxidative stress. Through this project, the new skills in the synthesis of antioxidant nanocapsules, the use of molecular biology techniques, design and fabrication of microfluidic models, project management, grant writing, and other transferable skills that I will acquire in IIT, will help my future career plans providing knowledge and expertise in a field where my knowledge is limited. This action will also give me the opportunity to transfer my pre-gained knowledge through seminars/workshops to the institution where my research will be carried out. Overall, I believe that BIONICS will have a significant impact on my short and long-term career goals and will bring me one step closer to my impending goal of the independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences basic medicine neurology stroke
- engineering and technology nanotechnology nano-materials
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
16163 GENOVA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.