Maximization of amplification of next-generation RNA replicon vaccines through synergistic molecular and formulation design

Project Information

RNAmpMax

Grant agreement ID: 794059

DOI

10.3030/794059

Project closed

EC signature date 14 March 2018

Start date 2 January 2019

End date 1 January 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 183 454,80

EU contribution

€ 183 454,80

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Ornithine-derived oligomers and dendrimers for in vitro delivery of DNA and ex vivo transfection of skin cells via saRNA

Author(s): Francesca Saviano, Tatiana Lovato, Annapina Russo, Giulia Russo, Clément R. Bouton, Robin J Shattock, Cameron Alexander, Fabiana Quaglia, Anna K. Blakney, Pratik Gurnani, Claudia Conte
Published in: Journal of Materials Chemistry B, Issue 8/22, 2020, Page(s) 4940-4949, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0tb00942c

Mannosylated Poly(ethylene imine) Copolymers Enhance saRNA Uptake and Expression in Human Skin Explants

Author(s): Anna K. Blakney, Yamin Abdouni, Gokhan Yilmaz, Renjie Liu, Paul F. McKay, Clément R. Bouton, Robin J. Shattock, C. Remzi Becer
Published in: Biomacromolecules, Issue 21/6, 2020, Page(s) 2482-2492, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c00445

An improved synthesis of poly(amidoamine)s for complexation with self-amplifying RNA and effective transfection

Author(s): Pratik Gurnani, Anna K. Blakney, Jonathan Yeow, Clément R. Bouton, Robin J. Shattock, Molly M. Stevens, Cameron Alexander
Published in: Polymer Chemistry, Issue 11/36, 2020, Page(s) 5861-5869, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0py00912a

The In Vitro , Ex Vivo , and In Vivo Effect of Polymer Hydrophobicity on Charge-Reversible Vectors for Self-Amplifying RNA

Author(s): Pratik Gurnani, Anna K. Blakney, Roberto Terracciano, Joshua E. Petch, Andrew J. Blok, Clément R. Bouton, Paul F. McKay, Robin J. Shattock, Cameron Alexander
Published in: Biomacromolecules, Issue 21/8, 2020, Page(s) 3242-3253, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c00698

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Author(s): Anna K. Blakney, Paul F. McKay, Bárbara Ibarzo Yus, Yoann Aldon, Robin J. Shattock
Published in: Gene Therapy, Issue 26/9, 2019, Page(s) 363-372, ISSN 0969-7128
Publisher: Nature Publishing Group
DOI: 10.1038/s41434-019-0095-2

Effect of complexing lipids on cellular uptake and expression of messenger RNA in human skin explants

Author(s): Anna K. Blakney, Polina Deletic, Paul F. McKay, Clément R. Bouton, Marianne Ashford, Robin J. Shattock, Alan Sabirsh
Published in: Journal of Controlled Release, 2020, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2020.11.033

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

Author(s): Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Jonathan C. Brown, Rebecca Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J. C. Lin, Christopher Barbosa, Ying K. Tam, Wendy S. Barclay, Robin J. Shattock
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17409-9

Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

Author(s): Anna K. Blakney, Yunqing Zhu, Paul F. McKay, Clément R. Bouton, Jonathan Yeow, Jiaqing Tang, Kai Hu, Karnyart Samnuan, Christopher L. Grigsby, Robin J. Shattock, Molly M. Stevens
Published in: ACS Nano, Issue 14/5, 2020, Page(s) 5711-5727, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c00326

Precisely targeted gene delivery in human skin using supramolecular cationic glycopolymers

Author(s): Anna K. Blakney, Renjie Liu, Gokhan Yilmaz, Yamin Abdouni, Paul F. McKay, Clément R. Bouton, Robin J. Shattock, C. Remzi Becer
Published in: Polymer Chemistry, Issue 11/22, 2020, Page(s) 3768-3774, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0py00449a