Objective
This action aims to discover a novel class of autophagy inhibitors and newly develop chemical probes that can identify their
protein targets and dissect their biological mode of action. Autophagy dysregulation is intrinsically linked with major
European healthcare challenges, including cancer. The identification of new classes of druggable autophagic proteins will
have broad implications for the development of novel and more effective cancer therapeutics. To address the aims of this
action, this proposal seeks support to initiate a pioneering and holistic chemical biology programme, which combines the
newest technologies in synthetic chemistry and cell biology. Phenotypic investigations in the host lab recently identified new
inhibitors of autophagy based on a novel scaffold, which modulates autophagy through an exciting but unknown pathway. In
this action the use of a newly introduced sp2-sp3 cross-coupling reaction will allow systematic variation of the scaffold,
exploration of its structure-activity relationship, and improvement of the potency of these inhibitors to facilitate the
preparation of high-quality chemical probes. A focused compound collection (>100 compounds) will be prepared and
investigated in cell-based assays, with the aim of establishing a broad, potent and selective class of inhibitors. The inhibitory
mode of action will then be rationalised through identification, validation and engagement of the associated biological targets
using further cell-based investigations and biophysical assays. Chemical probes will be generated from the most active
inhibitors and used to identify and interrogate the druggability of a novel protein target with potentially huge significance for
biomedical science. My ambition is to become an independent academic researcher in chemical biology at a leading
European institution, and this Fellowship provides a vital opportunity for me to advance my scientific and career potential.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.