Objective
Interspecies interactions between fungi and bacteria are highly prevalent in nature and are critically important in a variety of fields including agriculture, food processing, biotechnology, medicine, and dentistry. The study of such bacterial-fungal interactions (BFIs) can provide invaluable information regarding host-pathogen interactions that can be leveraged in understanding and treating important animal and plant diseases. The unique experimental tractability of the Rhizopus-Burkholderia endosymbiosis provides a model system for the investigation of the secreted factors central to BFIs. One remarkable feature in BFIs is the delivery of bacterial effector molecules that can take control of their eukaryotic host cell. FUNBIOSIS aims to speed up the discovery of natural compounds utilised by endosymbiotic Burkholderia sp. to control its fungal host by integrating the emerging technology of microfluidics. We will focus on novel effector molecules that: (i) can modulate host gene transcription (transcription activator-like effectors, TALEs); (ii) are associated with the recently discovered type 6 secretion system (T6SS); and (iii) are involved in chromatin-dependent changes in the host genome. This will not only elucidate the nature of host control in this commercially important BFI but also has the potential to serve as a roadmap to understanding how prokaryotic pathogens and symbionts interact with more complex eukaryotic hosts. Understanding the biology, ecology, and biotrophic interactions of the zygomycetes (of which Rhizopus microsporus is a member) with their associated endobacteria can help to identify novel secondary metabolites which are central to ecological functions and are useful for effective and innovative biotechnological utilisations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
07745 JENA
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.