Objective
Necrotising enterocolitis (NEC) is an inflammatory mediated bowel disease that causes more deaths after the first week of life in extremely preterm infants than any other single pathology, with prematurity and abnormal bacterial colonisation regarded as the most significant risk factors. However, 40 years of research have yielded few advances in treatment and the mechanisms of disease remain poorly understood. A major reason for this lack of progress relates to challenges in translating findings from non-invasive samples (e.g. stool) and the inability to robustly model bacterial-host crosstalk. To overcome this longstanding hurdle, the proposed PREMNEC (PReterm Enteroids to determine the Mechanisms of Necrotising EnteroColitis) fellowship will utilise a novel ex vivo preterm human intestinal enteroid (PHIE) co-culture model to systematically explore the gut microbiome and host functioning in preterm infants.
The fellowship is divided in three distinct work packages (WPs). In WP1, surgically resected intestinal tissue (otherwise discarded) from NEC and non-NEC infants will undergo characterisation utilising metagenomics, transcriptomics, proteomics, and cellular imaging directly on the fresh tissue. Concurrently, WP 2 will isolate crypt cells from the tissue to establish PHIEs that permit accurate and reproducible ex vixo co-culture of bacterial-host interaction. In WP 3, bacterial species isolated from preterm infants will be systematically added to the ex vixo co-culture model and comparable technologies utilised in WP 1 will be applied to determine the pathobiology of disease. Newcastle University will provide expertise in state-of-the-art transcriptomics and cellular imaging technologies.
Upon completion of this 24-month fellowship, I will have pioneered significant advancement in the mechanistic understanding of microbial-host interaction in the pathogenesis of NEC and identified potentially beneficial bacteria that may provide protection from NEC.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
NE1 7RU Newcastle Upon Tyne
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.