Objective
Mother-to-child transmission of HIV and Syphilis causes approximately 305,000 fetal and neonatal deaths every year and leaves 215,000 infants at increased risk of dying from prematurity, low-birth-weight or congenital disease. An accurate diagnosis of diagnostic-antibodies and a simple treatment during the first weeks of pregnancy could stop all those deaths.
Here, I propose the development of a new technique to be used to measure antibodies directly in whole blood. These will combine the multiplexed (i.e. multiple tests in parallel on one sample), quantitative performance of laboratory-based tests with the portability and low-cost of point-of-care tests. As the first step, I will design, optimize and test nanometer-scale, DNA-based “switches” that undergo a dramatic change in conformation (closed/open) upon recognizing its target antibody. I will use this conformational change to generate a large, easily measurable electronic (electrochemical) signal, which I will then employ in and validate as laboratory-scale, single-test devices using both purified antibodies and authentic human samples. I will then integrate the set of sensors exhibiting good clinical performances into a single, paper-based microfluidic sample handing device (similar to the home pregnancy test) to generate a low-cost platform capable of measuring multiple diagnostic antibodies in a single finger-prick blood sample.
The final and main goal in the DNA-SPADE project is the development of a working prototype diagnostic device, which I will design accordingly to suggestions/inputs from a variety of possible final users (such as nurses and doctors).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences clinical medicine obstetrics
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08193 BELLATERRA (BARCELONA)
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.