Objetivo Breast cancer is one of the most common causes of cancer-related death in women all over the world. Although therapeutic approach like surgery, chemotherapy, radiation and targeted therapy reduced the risk of cancer specific mortality. Still there is a risk of cancer recurrence and mortality. Cancer research is typically dependent on 2D system and animal model which leads to conflicting the result due to cellular behavior, phenotypes, gene expression level and expensive animal studies (Szot et al., 2011). In this way 3D microfluidics systems are designed to fulfill the gap between 2D and animal model for screening and testing of drug. The present proposal is conceptualize to bridge the gap between 2D and animal model effectively, by designing the Organs-on-chip (3D), microfluidics system of tumor microenvironment to evaluate the efficacy of combination of anticancerous drug. Herein, the multi-compartment microfluidics platform will be generated by co-culturing of cancer cells, fibroblast and endothelial cells into biocompatible hydrogel, to produce a multi-organ-on-a-chip devices. It recapitulates organ-like functions in each compartment and a vascular-channel between the compartments produce preliminary human on-chip. This 3D microfluidics system dedicated to evaluate the efficacy of anticancerous drug will be helpful to improve the future drug development applications. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicssocial sciencessociologydemographymortalitymedical and health sciencesclinical medicinesurgerymedical and health sciencesclinical medicineoncologybreast cancer Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2017 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2017 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-SE - Society and Enterprise panel Coordinador ELVESYS Aportación neta de la UEn € 185 076,00 Dirección 172 RUE DE CHARONNE B2 2 EME ETAGE 75011 Paris Francia Ver en el mapa Pyme Organización definida por ella misma como pequeña y mediana empresa (pyme) en el momento de la firma del acuerdo de subvención. Sí Región Ile-de-France Ile-de-France Paris Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 185 076,00
