Objective
The requirement for drug discovery to facilitate the identification of successful lead candidates has challenged synthetic chemists to develop innovative strategies to rapidly generate screening collections of chiral molecules. Recently, the application of asymmetric aminocatalysis to cascade reactions has addressed this target enabling extraordinary levels of sophistication and stereocontrol, while fulfilling the requirements for both atom and step economy. Because of the rapid progress achieved, the general perception is that it would be difficult to further expand the synthetic potential of the aminocatalytic cascade approach. However, recent works from the host´s laboratories demonstrate that, by exploiting the photochemical activity of organocatalytic intermediates, light irradiation unlocks reaction pathways unavailable in the ground-state domain. In particular, by bringing a catalytically generated iminium ion to an electronically excited state, it is possible to perform β-functionalisations of enals not achievable under thermal control.
This proposal seeks to capitalise upon this novel reactivity to further expand the synthetic potential of the organocatalytic cascade technique, by providing new opportunities for reaction invention. We plan to accomplish this by exploiting the photochemistry of iminium ions in processes that synergistically combine enamine chemistry with transition metal catalysis, thus merging, for the first time, tandem organo-metal catalysis with asymmetric photoreactions. The planned research combines perfectly the host´s expertise in photochemical organocatalysis with the fellow´s experience in transition metal catalysis. These enantioselective cascade reactions will be used for the synthesis of chiral molecules of biological interest. The libraries generated will serve as a platform for the design and development of potential drug candidates. The biological evaluation will be undertaken in collaboration with an international recognized
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences physical chemistry photochemistry
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
43007 TARRAGONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.