Objetivo Obesity is a metabolic disorder with unmet medical need for which a pharmacotherapy is urgently needed. The Domingos lab has recently discovered that sympathetic (SNS) neuro-adipose junctions mediate lipolysis and fat mass reduction (Pirzgalska, R.M. Cell, 2015).Thus direct and targeted activation of sympathetic inputs to adipose tissues could represent a new strategy for the induction of fat loss. Our main objective is to identify drug targets in SNS neurons innervating fat, which are suitable for an anti-obesity therapy. To achieve this, we will use technologies such as Translational Ribosome Affinity Purification (TRAP) for translational profiling of neurons innervating fat. We will differentially screen for molecular targets that are enriched in SNS neurons in fat. We will validate target expression in human SNS tissues. This project will identify neuro-excitatory drug targets in sympathetic inputs to adipose tissues, and may lead the development of pharmacotherapies which would circumvent side effects. Ámbito científico medical and health scienceshealth sciencesnutritionobesity Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2017 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2017 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Aportación neta de la UEn € 183 454,80 Dirección WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Reino Unido Ver en el mapa Región South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 183 454,80
