Objective
Nowadays, there is a growing concern in the research community and civil society in general about the effects of chemical exposure on human health. From a public health perspective, it is of major interest to establish the risks associated with chemicals for the enforcement of health prevention strategies. In this sense, one of the current priorities of chemical risk assessment is to understand the effects and modes of action (MoA) of endocrine disruptor compounds (EDCs) such as bisphenol A (BPA) and polychlorinated bisphenyls (PCBs). Within this framework, metabolomics has emerged as a novel strategy for the discovery of effect biomarkers that can provide the connection between exposures to EDCs and chronic diseases.
HAZARDOmics aims to enhance the knowledge about the risks arising from exposures to low doses of BPA and to a ‘cocktail’ of PCBs following an innovative metabolomics approach. The metabolic profiling of blood serum samples will be investigated from a broad analytical perspective in order to obtain the most complete information of metabolic fingerprint and, consequently, to increase the possibility of identifying effect biomarkers. Liquid chromatography (LC)-High Resolution Mass Spectrometry (HRMS) involving Reverse Phase Liquid Chromatography (RP-LC) and Hydrophilic Interaction Liquid Chromatography (HILIC) will be employed as traditional metabolomics strategy in risk assessment. On the other hand, the boundaries of this approach will be extended by the application of two additional techniques. For the first time, Ion Mobility Spectrometry (IM) integrated in a LC-HRMS workflow will be evaluated as a ground-breaking technology for metabolomics intended to risk assessment purposes. Moreover, Capillary Electrophoresis (CE)-HRMS will be implemented as complementary technique to LC-HRMS since both involve different separation mechanisms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- social sciences political sciences political policies civil society
- natural sciences chemical sciences electrochemistry electrophoresis
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
44307 Nantes
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.