Objective
Thallusin was the first compound identified to induce thallus differentiation in macroalgae. This intriguing chemical mediator is produced by bacteria that socialize with algae in their natural habitat. Thallusin exemplifies a fundamental symbiotic chemical communication between macroalgae and epiphytic bacteria in the marine environment. However, its general impact on the underlying microbial communities and its chemical mode-of-action remains to be clarified. Therefore we propose a multifaceted research program to study the morphogenesis-inducing mechanism of algae by chemical morphogen. The proposed project will focus at four different objectives. 1) methodology development (heteroarylative/cyclization cascade), that allows the efficient and concise synthesis of thallusin. This will be achieved by ligand directed transition metal catalysis based on good literature precedent. The first objective is scheduled to be completed in first six month of the project. 2) development of novel, concise, scalable, and efficient asymmetric synthesis of (‒)-thallusin and its analogues. This will be accomplished by enantioselective polyene cyclization and heteroarylative/cyclization cascade as key steps. The second objective is scheduled to be completed from months 6-12 and 17-20. 3) structure-activity- relationships studies and 4) understanding the mode-of-action of thallusin in algae. The objective 3 and 4 will be completed in collaborations. The labeled tool compounds and dye conjugates will be synthesized from promising candidates that will allow tracing the metabolism and degradation of thallusin in algae. The 3 and 4 objective is scheduled to be completed from 9-24 months. The results that will be obtained during the course of our research will have the potential capacity to enlighten the cross-kingdom cell-to-cell chemical signaling and will provide room for further studies at the fundamental and applied levels in green algae and symbiotic bacteria association.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology phycology
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
07743 JENA
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.