Description du projet
Des cellules synthétiques avancées
La création de cellules synthétiques ou artificielles destinées à reproduire certaines des propriétés et fonctions fondamentales des cellules vivantes constitue un domaine de recherche fascinant. Les cellules artificielles servent non seulement de modèles simplifiés permettant d’étudier le comportement cellulaire et d’explorer les origines de la vie, mais servent également à la production de composés pharmaceutiques et thérapeutiques. Les cellules synthétiques sont généralement constituées de bicouches lipidiques, semblables aux membranes cellulaires présentes dans les organismes vivants. Toutefois, la mise au point de coques artificielles imitant les propriétés mécaniques, la fonctionnalité et la réponse aux stimuli de la membrane cellulaire naturelle reste un défi. Financé par le programme Actions Marie Skłodowska-Curie, le projet ARC-for-CORE entend développer une coque artificielle bio-inspirée capable de compartementalisation et de réactivité biologique incluant un transport bidirectionnel sélectif.
Objectif
This project is to build an artificial compartment for coenzyme regeneration, urgently demanded by industry and scientific research to enhance the stoichiometric use of coenzyme in biosynthetic pathways. The fellow will investigate all-round aspects of the bio-inspired system, including compartmentalization process, mass transfer and biological reactivity. A new mechanism for selective bidirectional transport and structure-reinforced composite shell will be proposed. Capitalizing upon his expertise in biomimetic controlled delivery system, carbon nanomaterial, emulsion and scanning electrochemistry, the fellowship makes him a unique asset to EU for the brand-new exploration of bio-inspired selective transport system and coenzyme regeneration compartment. The fellow has proven track record with multi- and interdisciplinary background and his achievement has been outstanding as demonstrated in CV. The skills he will gain allow him to diversify his capability significantly, including interfacial polymerization and molecular imprinting technique, visualized delivery dynamics, capsule manipulation and stability test, enzymatic integrity and activity test, compartmentalized enzymatic reaction, microfluidic multiple emulsification and techniques for SECM set-ups and analysis. The output will be the knowledge obtained from the formation of the artificial compartment through bulk and microfluidic interfacial polymerization, the compartmentalized enzymatic reactions and new set-ups for SECM. In addition, the fellowship will allow him to transfer his existing knowledge and the one emerged from the research to the hosts and a variety of audience, via complementary activities. The effective and reliable coenzyme regeneration system will address the challenge of coenzyme utilization in the biological industry. Fostered by the fellowship, a leading expert in biomimicry and coenzyme regeneration is expected to contribute greatly to EU industries and academic communities.
Champ scientifique
Programme(s)
Régime de financement
MSCA-IF-EF-ST - Standard EFCoordinateur
80539 Munchen
Allemagne