Descrizione del progetto
Cellule sintetiche avanzate
La creazione di cellule sintetiche o artificiali per replicare alcune delle proprietà e funzioni fondamentali delle cellule viventi costituisce un affascinante area di ricerca. Le cellule artificiali fungono non solo da modelli semplificati per studiare il comportamento cellulare ed esplorare le origini della vita, ma anche da fonte per la produzione di composti farmaceutici e terapeutici. Le cellule sintetiche vengono solitamente costruite a partire da bistrati lipidici, simili alle membrane cellulari presenti negli organismi viventi. Tuttavia, la realizzazione di involucri artificiali che imitino la membrana cellulare naturale in termini di proprietà meccaniche, funzionalità e risposta agli stimoli rappresenta tuttora una sfida. Finanziato dal programma di azioni Marie Skłodowska-Curie, il progetto ARC-for-CORE mira a sviluppare un involucro artificiale bio-ispirato con capacità di compartimentazione e reattività biologica, compreso il trasporto selettivo bidirezionale.
Obiettivo
This project is to build an artificial compartment for coenzyme regeneration, urgently demanded by industry and scientific research to enhance the stoichiometric use of coenzyme in biosynthetic pathways. The fellow will investigate all-round aspects of the bio-inspired system, including compartmentalization process, mass transfer and biological reactivity. A new mechanism for selective bidirectional transport and structure-reinforced composite shell will be proposed. Capitalizing upon his expertise in biomimetic controlled delivery system, carbon nanomaterial, emulsion and scanning electrochemistry, the fellowship makes him a unique asset to EU for the brand-new exploration of bio-inspired selective transport system and coenzyme regeneration compartment. The fellow has proven track record with multi- and interdisciplinary background and his achievement has been outstanding as demonstrated in CV. The skills he will gain allow him to diversify his capability significantly, including interfacial polymerization and molecular imprinting technique, visualized delivery dynamics, capsule manipulation and stability test, enzymatic integrity and activity test, compartmentalized enzymatic reaction, microfluidic multiple emulsification and techniques for SECM set-ups and analysis. The output will be the knowledge obtained from the formation of the artificial compartment through bulk and microfluidic interfacial polymerization, the compartmentalized enzymatic reactions and new set-ups for SECM. In addition, the fellowship will allow him to transfer his existing knowledge and the one emerged from the research to the hosts and a variety of audience, via complementary activities. The effective and reliable coenzyme regeneration system will address the challenge of coenzyme utilization in the biological industry. Fostered by the fellowship, a leading expert in biomimicry and coenzyme regeneration is expected to contribute greatly to EU industries and academic communities.
Campo scientifico
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF-EF-ST - Standard EFCoordinatore
80539 Munchen
Germania