Objective
The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins. TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ubiquitinating system and the target protein in close proximity, so to promote degradation of the latter. The formation of the ternary complex (target protein-TPDI-E3 ligase) is an articulated process influenced by a series of factors, such as ligands affinity, linker length and composition and molecular features of the proteins involved. The project tackles this endeavour in stages of increasing innovation, progressively incrementing the scope, flexibility and efficiency of modular synthetic access to arrays of tripartite molecules via protected, solid grafted intermediates, combinable with a variety of target ligands. New chemical entities TPDIs will be generated targeting selected purinome proteins oncology-related.
This project will be pursued within the Chemical Core Technologies Dept. of a fully integrated company (NMS), engaged in the discovery and development of new small molecule based drugs. Organic and solid phase chemistry, computational and structural chemistry, molecular and cell biology, among others, will be exploited to achieve the project’s goal. In such multidisciplinary environment, this new technology will grow at the same speed with the researcher’s medchem competence, increasing the chance of mutual success. DETRIMODE outcomes will be shared with peers, while updates on its progresses as well as general information on how EC-funded research have impact on the general public will be communicated by a number of means, bringing science closer to society
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-SE - Society and Enterprise panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20014 NERVIANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.