Dissecting mGlu5 receptor internalization pathways using genetic and pharmacological tools

Project Information

INTERGLU

Grant agreement ID: 797497

DOI

10.3030/797497

Project closed

EC signature date 1 March 2018

Start date 1 November 2018

End date 31 October 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 212 194,80

EU contribution

€ 212 194,80

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

Author(s): Mie Fabricius Pedersen, Tomasz Marcin Wróbel, Emil Märcher-Rørsted, Daniel Sejer Pedersen, Thor Christian Møller, Federica Gabriele, Henrik Pedersen, Dariusz Matosiuk, Simon Richard Foster, Michel Bouvier, Hans Bräuner-Osborne
Published in: Neuropharmacology, Issue 166, 2020, Page(s) 107718, ISSN 0028-3908
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2019.107718

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

Author(s): Thor C. Møller, Mie F. Pedersen, Jeffrey R. van Senten, Sofie D. Seiersen, Jesper M. Mathiesen, Michel Bouvier, Hans Bräuner-Osborne
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-73674-0

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis

Author(s): Martina Sundqvist, André Holdfeldt, Shane C. Wright, Thor C. Møller, Esther Siaw, Karin Jennbacken, Henrik Franzyk, Michel Bouvier, Claes Dahlgren, Huamei Forsman
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1867/12, 2020, Page(s) 118849, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/j.bbamcr.2020.118849

Staphylococcus aureus –Derived PSMα Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate β-Arrestin Recruitment and Chemotaxis

Author(s): Martina Sundqvist, Karin Christenson, Michael Gabl, André Holdfeldt, Karin Jennbacken, Thor C. Møller, Claes Dahlgren, Huamei Forsman
Published in: The Journal of Immunology, Issue 203/12, 2019, Page(s) 3349-3360, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1900871

International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function

Author(s): Katie Leach, Fadil M. Hannan, Tracy M. Josephs, Andrew N. Keller, Thor C. Møller, Donald T. Ward, Enikö Kallay, Rebecca S. Mason, Rajesh V. Thakker, Daniela Riccardi, Arthur D. Conigrave, Hans Bräuner-Osborne
Published in: Pharmacological Reviews, Issue 72/3, 2020, Page(s) 558-604, ISSN 0031-6997
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/pr.119.018531

Positive allosteric modulators of metabotropic glutamate receptor 5 as tool compounds to study signaling bias

Author(s): Angela Arsova, Thor C. Møller, Shane D. Hellyer, Line Vedel, Simon R. Foster, Jakob L. Hansen, Hans Bräuner-Osborne, Karen J. Gregory
Published in: Molecular Pharmacology, Issue 99/5, 2021, Page(s) MOLPHARM-AR-2020-000185, ISSN 0026-895X
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/molpharm.120.000185

Arrestin-Dependent and -Independent Internalization of G Protein–Coupled Receptors: Methods, Mechanisms, and Implications on Cell Signaling

Author(s): Ee Von Moo, Jeffrey R. van Senten, Hans Bräuner-Osborne, Thor C. Møller
Published in: Molecular Pharmacology, Issue 99/4, 2021, Page(s) 242-255, ISSN 0026-895X
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/molpharm.120.000192

Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Author(s): Angela Arsova, Thor C. Møller, Line Vedel, Jakob Lerche Hansen, Simon R. Foster, Karen J. Gregory, Hans Bräuner-Osborne
Published in: Molecular Pharmacology, Issue 98/1, 2020, Page(s) 49-60, ISSN 0026-895X
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/mol.119.119032