Objective
Perception is shaped both by sensory information and internal variables. Our brain uses regularities of environmental factors to make predictions, and combines them with sensory stimuli to form percepts. However, where and how the statistical knowledge of the environment is stored and learned remains unexplored. Visual perception arises from a set of hierarchically-organized cortical areas, with abundant feedback connections from higher to lower areas. In this proposal, I will test if knowledge of the world is stored in the connectional specificity of feedback projections. I hypothesize that the tuning-specific wiring pattern of feedback projections terminating in mouse primary visual cortex (V1) reflects spatiotemporal statistics of the visual environment. To do so, I will first assess the role of sensory experience in feedback wiring. I will visually-deprive mice or raise them in artificial environments with altered visual statistics. Using a novel combination of dual-color optical recordings, I will measure how connectional specificity of functionally characterized feedback axons in V1 relates to the animal’s visual experience. I will also determine if spatiotemporal patterns of neuronal activity are sufficient for establishing the wiring organization. Shedding light on the enigmatic role of feedback connections will also provide a mechanistic description of how internal factors shape perception. The specific deficits in feedback function could have a potential bearing on behavioral disorders like schizophrenia in which patients manifest a difficulty in learning and representing behaviorally relevant percepts when the selection of relevant information is determined by prior knowledge. Thus, this work will not only be imperative for a better understanding of how prior knowledge influence perception, but also for getting a deeper insight into brain disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences clinical medicine psychiatry schizophrenia
- natural sciences computer and information sciences artificial intelligence machine learning
- natural sciences physical sciences theoretical physics particle physics photons
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1400-038 LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.