Modulation of the glymphatic system: a novel tool for drug delivery to the central nervous system

Project Information

GLYMPHARMA

Grant agreement ID: 798944

DOI

10.3030/798944

Project closed

EC signature date 21 March 2018

Start date 1 October 2018

End date 21 December 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 200 194,80

EU contribution

€ 200 194,80

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (3)

Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression

Author(s): Kim J. Blomqvist, Hanna Viisanen, Fredrik H.G. Ahlström, Viljami Jokinen, Yulia A. Sidorova, Ilida Suleymanova, Pekka V. Rauhala, Eija A. Kalso, Tuomas O. Lilius
Published in: European Journal of Pharmacology, Issue 875, 2020, Page(s) 173021, ISSN 0014-2999
Publisher: Elsevier BV
DOI: 10.1016/j.ejphar.2020.173021

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

Author(s): Tuomas O. Lilius, Kim Blomqvist, Natalie L. Hauglund, Guojun Liu, Frederik Filip Stæger, Simone Bærentzen, Ting Du, Fredrik Ahlström, Janne T. Backman, Eija A. Kalso, Pekka V. Rauhala, Maiken Nedergaard
Published in: Journal of Controlled Release, Issue 304, 2019, Page(s) 29-38, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.05.005

Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats

Author(s): Kim Juhani Blomqvist, Katarzyna Anna Dudek, Hanna Viisanen, Kert Mätlik, Fredrik Harry Gustav Ahlström, Jouko Laitila, Eija Anneli Kalso, Pekka Veli Rauhala, Tuomas Olavi Lilius
Published in: Journal of Neuroscience Research, 2020, ISSN 0360-4012
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jnr.24638