Objective
PROMPT will develop a new generation of photosensitizers targeting mitochondria in cancer cells, to be used in photodynamic therapy (PDT). The innovative approach of PROMPT is based on the design and synthesis of porphyrinoids functionalized with aromatic heterocyclic groups containing C-S bonds. These molecules are expected to localize specifically in mitochondria of cancer cells and to efficiently generate singlet oxygen, leading to apoptosis induction and cell death. Loading of the photosensitizers into liposomes ad hoc functionalized to target mitochondria is also envisaged in case of need. The innovative photodynamic treatment will thus show high selectivity, lower dose of treatment and reduced side effects with respect to the presently used phototherapy approaches. Moreover, the new molecules are expected to show significant two-photon absorption properties, due to the extended conjugation of the porphyrinoid core introduced by the aromatic side groups. They will thus represent a groundbreaking class of mitochondria-targeted photosensitizers for both one- and two-photon PDT. The multidisciplinarity of PROMPT, together with the proposed work plan in a forefront area of bio-medical research, will widen the scientific skills and technological know-how of the Experienced Researcher, significantly improving his career opportunities both in the academic and private sectors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00185 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.