Objective
Infection with gastrointestinal parasites is one of the most severe impediments on sustainable production of meat and milk from grazing livestock. Widespread resistance to the small number of available synthetic drugs has rendered continued prophylactic drug treatment unsustainable. One solution is to graze animals on bioactive forages that contain bioactive compounds with anti-parasitic activity such as condensed tannins (CT). This approach has been shown to be effective in reducing parasitic infection in grazing sheep and cattle, but as yet the anthelmintic mechanism of CT is unknown. The aim of the current proposal is to use highly purified CT molecules to investigate how CT bind to nematode parasites, and the role of CT polymer size in the binding properties. Furthermore, transcriptomics and functional biochemical experiments will be used to elucidate the biological pathways that are perturbed in nematodes after exposure to sub-lethal doses of CT in vitro. This unique multidisciplinary project will involve leading groups in both veterinary parasitology and phytochemistry, and combine the latest techniques in molecular parasitology and tannin chemistry. It is envisaged that the unique skill sets obtained from the project will be highly beneficial to my future career, as well as uncovering novel insights into the biological properties of CT that will greatly aid the practical future use of CT-containing forages, thus ensuring the continued sustainability of pasture-based livestock production.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences parasitology
- natural sciences chemical sciences polymer sciences
- agricultural sciences agriculture, forestry, and fisheries agriculture industrial crops fodder
- agricultural sciences animal and dairy science domestic animals animal husbandry
- social sciences economics and business economics sustainable economy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.