Innovative tool for personalized treatment of patients with neovascular age-macular degeneration: dosage optimization for long term efficacy treatment

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Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Auteurs: Astrid Subrizi, Eva M. del Amo, Viktor Korzhikov-Vlakh, Tatiana Tennikova, Marika Ruponen, Arto Urtti
Publié dans: Drug Discovery Today, Numéro 24/8, 2019, Page(s) 1446-1457, ISSN 1359-6446
Éditeur: Elsevier BV
DOI: 10.1016/j.drudis.2019.02.001

Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits

Auteurs: Anam Fayyaz, Veli-Pekka Ranta, Elisa Toropainen, Kati-Sisko Vellonen, Giuseppe D’Amico Ricci, Mika Reinisalo, Emma M. Heikkinen, Iain Gardner, Arto Urtti, Masoud Jamei, Eva M. del Amo
Publié dans: Molecular Pharmaceutics, 2020, ISSN 1543-8384
Éditeur: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.9b01024

Role of retinal pigment epithelium permeability in drug transfer between posterior eye segment and systemic blood circulation

Auteurs: Eva Ramsay, Marja Hagström, Kati-Sisko Vellonen, Susanna Boman, Elisa Toropainen, Eva M. del Amo, Heidi Kidron, Arto Urtti, Marika Ruponen
Publié dans: European Journal of Pharmaceutics and Biopharmaceutics, Numéro 143, 2019, Page(s) 18-23, ISSN 0939-6411
Éditeur: Elsevier BV
DOI: 10.1016/j.ejpb.2019.08.008

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Auteurs: Emma M. Heikkinen, Seppo Auriola, Veli-Pekka Ranta, Nicholas J. Demarais, Angus C. Grey, Eva M. del Amo, Elisa Toropainen, Kati-Sisko Vellonen, Arto Urtti, Marika Ruponen
Publié dans: Molecular Pharmaceutics, Numéro 16/9, 2019, Page(s) 3968-3976, ISSN 1543-8384
Éditeur: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.9b00585

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