Objective Tick-borne encephalitis virus (TBEV) is emerging in Europe. It causes tick-borne encephalitis (TBE), a disease with a high mortality rate and even higher rates of life-long neurological effects in individuals that contract infections. As environmental and societal changes promote viral spread and current vaccine use is limited, it is not surprising that TBE incidence is on the rise. With uncertain diagnostics and no medications on the market, the threat to European health care becomes significant, making development of control measures a high priority. Efforts to develop treatments and improve detection are largely hampered by a lack of structural knowledge about TBEV. Here we seek to fill the critical information gap, using electron cryo-microscopy, which has become a powerful technology for revealing atomic-level details about viruses. We will harness unique expertise in the fields of virology and structural biology to answer fundamental questions about virus structure, assembly, morphogenesis, and function. Explicit new knowledge regarding TBEV will push forward European excellence in virus research producing impactful results for their exploitation in drug discovery and diagnostic developments. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesphysical sciencesopticsmicroscopyelectron microscopymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesmolecular biologystructural biology Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2017 - Individual Fellowships Call for proposal H2020-MSCA-IF-2017 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator HELSINGIN YLIOPISTO Net EU contribution € 179 325,60 Address YLIOPISTONKATU 3 00014 Helsingin Yliopisto Finland See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 179 325,60