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Cell-free Ti-based Medical Implants due to Laser-induced Microstructures

Project description

Surface modification of medical implants to prevent cell overgrowth

Smart medical implants find applications in all medical fields, including miniaturised pacemakers. The implants with a Titanium-alloy are less overgrown by the cells and can be easily removed or replaced. Recently developed Titanium-alloy substrate with self-organised spikes covered with sub-micrometer ripples created by laser-ablation provides too little surface for cell growth. The EU-funded CellFreeImplant project focuses on finding partners for the future development of smart implants with patient needs in mind. The project will identify at least four different market segments for miniaturised and smart medical implants. The customised samples with surfaces modified by laser-induced micro- and nano-structures will be provided for assessment by the potential strategic partners.

Objective

New miniaturized and smart medical implants are more and more used in all medical fields, including miniaturized pacemakers. These implants with a casing consisting often of a Ti-alloy may have to be removed after some months or several years and shall therefore not be completely overgrown by the cells. In the framework of the ongoing FET Open project LiNaBioFluid, we successfully demonstrated that self-organized sharp cones or spikes at Ti-alloy substrates created by pulsed laser-ablation can result not only in complete wetting by water and body fluids but at the same time provide too little surface for the cells (i.e. fibroblasts) to grow on. Compared to flat surfaces, the cell density on the microstructures is significantly lowered, the coverage is incomplete and the cells have a clearly different morphology. The best results regarding suppression of cell growth are obtained on structures created by femtosecond Ti:sapphire laser irradiation, which are subsequently electrochemically treated. The goal of the Coordination and Support Action CellFreeImplant is to find strategic partners (end-users) for future development of smart medical implants addressing wide-spread patients needs for instance in the field of cardio-vascular diseases. The project activities include the identification of the market segments and needs and assessment of the technology with end-users.

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Topic(s)

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CSA - Coordination and support action

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Call for proposal

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(opens in new window) H2020-FETOPEN-2016-2017

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Coordinator

UNIVERSITAT LINZ
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 50 000,00
Address
ALTENBERGER STRASSE 69
4040 Linz
Austria

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Region
Westösterreich Oberösterreich Linz-Wels
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 50 000,00

Participants (2)

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