Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma.

Project Information

EDIT

Grant agreement ID: 801126

DOI 10.3030/801126

Project closed

EC signature date 24 May 2018

Start date 1 October 2018

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 4 317 160,00

EU contribution € 4 317 160,00

Coordinated by

OSPEDALE SAN RAFFAELE SRL
Italy

Deliverables

Demonstrators, pilots, prototypes (1)

Report on the development of machine learning algorithms.

Report on the development of machine learning algorithms

Websites, patent fillings, videos etc. (4)

At least 5 conferences and at least 3 peer-reviewed papers
Second plan for dissemination and exploitation for ( PUDF)
Workshop outside the consortium
Project website and logo

Documents, reports (5)

First plan for dissemination and exploitation (using and disseminating the foreground (=PUDF))

First plan for dissemination and exploitation (using and disseminating the foreground (=PUDF))

Final plan for using and disseminating the foreground (PUDF)

plan for using and disseminating the foreground PUDF

Report on novel biomarkers of bladder Cis
Report on the validation of the 3D visualization platform
PR3 - Agenda and Presentations

PR3 Agenda and Presentations for the preparation of the Periodic Review PR3 meeting

Publications

Peer reviewed articles (22)

The glycocalyx affects the mechanotransductive perception of the topographical microenvironment

Author(s): Matteo Chighizola; Tania Dini; Stefania Marcotti; Mirko D’Urso; Claudio Piazzoni; Francesca Borghi; Anita Previdi; Laura Ceriani; Claudia Folliero; Brian Stramer; Cristina Lenardi; Paolo Milani; Alessandro Podestà; Carsten Schulte
Published in: Journal of Nanobiotechnology, Issue 4, 2022, ISSN 1477-3155
Publisher: BioMed Central
DOI: 10.1186/s12951-022-01585-5

A stapled chromogranin A-derived peptide homes in on tumors that express avb6 or avb8 integrins

Author(s): Matteo Monieri, Paolo Rainone, Angelina Sacchi, Alessandro Gori, Anna Maria Gasparri, Angela Coliva, Antonio Citro, Benedetta Ferrara, Martina Policardi, Silvia Valtorta, Arianna Pocaterra, Massimo Alfano, Dean Sheppard, Lorenzo Piemonti, Rosa Maria Moresco, Angelo Corti, Flavio Curnis.
Published in: International Journal of Biological Sciences, Issue 2023 VOLUME 19, 2023, Page(s) 156-166, ISSN 1449-2288
Publisher: Ivyspring International Publisher
DOI: 10.7150/ijbs.76148

Causal contributors to tissue stiffness and clinical relevance in urology

Author(s): Laura Martinez-Vidal, Valentina Murdica, Chiara Venegoni, Filippo Pederzoli, Marco Bandini, Andrea Necchi, Andrea Salonia, Massimo Alfano
Published in: Communications Biology, Issue 4/1, 2021, Page(s) 1-16, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-021-02539-7

Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody

Author(s): Lena Cohen, Irit Sagi, Einat Bigelman, Inna Solomonov, Anna Aloshin, Jeremy Ben-Shoshan, Zach Rozenbaum, Gad Keren, Michal Entin-Meer
Published in: PLOS ONE, Issue 15/4, 2020, Page(s) e0231202, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0231202

An Application of Multivariate Data Analysis to Photoacoustic Imaging for the Spectral Unmixing of Gold Nanorods in Biological Tissues

Author(s): Mirko Maturi, Paolo Armanetti, Luca Menichetti, Mauro Comes Franchini
Published in: Nanomaterials, Issue 11/1, 2021, Page(s) 142, ISSN 2079-4991
Publisher: RSC (Royal Chemical Society)
DOI: 10.3390/nano11010142

Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level

Author(s): M. Chighizola, A. Previdi, T. Dini, C. Piazzoni, C. Lenardi, P. Milani, C. Schulte, A. Podestà
Published in: Nanoscale, Issue 12/27, 2020, Page(s) 14708-14723, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr01991g

Distinct extracellular–matrix remodeling events precede symptoms of inflammation

Author(s): Elee Shimshoni, Idan Adir, Ran Afik, Inna Solomonov, Anjana Shenoy, Miri Adler, Luca Puricelli, Fabio Sabino, Simonas Savickas, Odelia Mouhadeb, Nathan Gluck, Sigal Fishman, Lael Werner, Tomer-Meir Salame, Dror S. Shouval, Chen Varol, Ulrich auf dem Keller, Alessandro Podestà, Tamar Geiger, Paolo Milani, Uri Alon, Irit Sagi
Published in: Matrix Biology, Issue 96, 2021, Page(s) 47-68, ISSN 0945-053X
Publisher: Elsevier BV
DOI: 10.1016/j.matbio.2020.11.001

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

Author(s): Mazor RD, Nathan N, Gilboa A, Stoler-Barak L, Moss L, Solomonov I, Hanuna A, Divinsky Y, Shmueli MD, Hezroni H, Zaretsky I, Mor M, Golani O, Sabah G, Jakobson-Setton A, Yanichkin N, Feinmesser M, Tsoref D, Salman L, Yeoshoua E, Peretz E, Erlich I, Cohen NM, Gershoni JM, Freund N, Merbl Y, Yaari G, Eitan R, Sagi I, Shulman Z.
Published in: Cell, Issue 185 (7), 2022, Page(s) 1559-8985, ISSN 0082-1527
Publisher: Cambridge, Massachusetts, United States
DOI: 10.1016/j.cell.2022.02.012

Stiffening of DU145 prostate cancer cells driven by actin filaments – microtubule crosstalk conferring resistance to microtubule-targeting drugs

Author(s): Andrzej Kubiak, Matteo Chighizola, Carsten Schulte, Natalia Bryniarska, Julita Wesołowska, Maciej Pudełek, Małgorzata Lasota, Damian Ryszawy, Agnieszka Basta-Kaim, Piotr Laidler, Alessandro Podestà, Małgorzata Lekka
Published in: Nanoscale, Issue 13/12, 2021, Page(s) 6212-6226, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr06464e

Mechanotransduction in neuronal cell development and functioning

Author(s): Matteo Chighizola, Tania Dini, Cristina Lenardi, Paolo Milani, Alessandro Podestà, Carsten Schulte
Published in: Biophysical Reviews, Issue 11/5, 2019, Page(s) 701-720, ISSN 1867-2450
Publisher: Springer Verlag
DOI: 10.1007/s12551-019-00587-2

Force sensing on cells and tissues by atomic force microscopy

Author(s): Hatice Holuigue; Ewelina Lorenc; Matteo Chighizola; Carsten Schulte; Luca Varinelli; Marcello Deraco; Marcello Guaglio; Manuela Gariboldi; Alessandro Podestà
Published in: Sensors, Issue 3, 2022, Page(s) 2197, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22062197

Current concepts in nanostructured contrast media development for in vivo photoacoustic imaging

Author(s): Mirko Maturi, Erica Locatelli, Ilaria Monaco, Mauro Comes Franchini
Published in: Biomaterials Science, Issue 7/5, 2019, Page(s) 1746-1775, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8bm01444b

Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression

Author(s): Alakesh Das, Vishnu Mohan, Venkat Raghavan Krishnaswamy, Inna Solomonov, Irit Sagi
Published in: Cancer and Metastasis Reviews, 2019, Page(s) 455–468, ISSN 0072-7830
Publisher: springer science & business media
DOI: 10.1007/s10555-019-09813-5

A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

Author(s): Francesca Nardelli, Michela Ghitti, Giacomo Quilici, Alessandro Gori, Qingqiong Luo, Andrea Berardi, Angelina Sacchi, Matteo Monieri, Greta Bergamaschi, Wolfgang Bermel, Fuxiang Chen, Angelo Corti, Flavio Curnis, Giovanna Musco
Published in: Chemical Communications, 2019, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc08518a

MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

Author(s): Mark Owyong, Jonathan Chou, Renske JE van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard, Dalit Talmi-Frank, Inna Solomonov, Charlotte Koopman, Elin Hadler-Olsen, Mark Headley, Charlene Lin, Chih-Yang Wang, Irit Sagi, Zena Werb, Vicki Plaks
Published in: Life Science Alliance, Issue 2/6, 2019, Page(s) e201800226, ISSN 2575-1077
Publisher: Cold Spring Harbor Laboratory
DOI: 10.26508/lsa.201800226

LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis

Author(s): Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.00480

Influence of natural convection on gold nanorods-assisted photothermal treatment of bladder cancer in mice

Author(s): Ean H. Ooi, Viktor Popov, Massimo Alfano, Jason K. K. Cheong
Published in: International Journal of Hyperthermia, Issue 37/1, 2020, Page(s) 634-650, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2020.1771437

Decellularized extracellular matrix as scaffold for cancer organoid cultures of colorectal peritoneal metastases

Author(s): Luca Varinelli, Marcello Guaglio, Silvia Brich, Susanna Zanutto, Antonino Belfiore, Federica Zanardi, Fabio Iannelli, Amanda Oldani, Elisa Costa, Matteo Chighizola, Ewelina Lorenc, Simone P Minardi, Stefano Fortuzzi, Martina Filugelli, Giovanna Garzone, Federica Pisati, Manuela Vecchi, Giancarlo Pruneri, Shigeki Kusamura, Dario Baratti, Laura Cattaneo, Dario Parazzoli, Alessandro Podestà, Massimo
Published in: J. Molecular Cell Biology, Issue mjac064, 2022, ISSN 1759-4685
Publisher: Oxford University Press
DOI: 10.1093/jmcb/mjac064

Large colloidal probes for atomic force microscopy: Fabrication and calibration issues

Author(s): Matteo Chighizola; Luca Puricelli; Ludovic Bellon; Alessandro Podestà
Published in: Journal of molecular recognition, Issue 3, 2020, ISSN 0952-3499
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmr.2879

Gold nanorods assisted photothermal therapy of bladder cancer in mice: A computational study on the effects of gold nanorods distribution at the centre, periphery, and surface of bladder cancer

Author(s): Jason Kk Cheong, Ean H Ooi, Yeong S Chiew , Luca Menichetti, Paolo Armanetti, Mauro Comes Franchini, Elisa Alchera, Irene Locatelli, Tamara Canu, Mirko Maturi, Viktor Popov, Massimo Alfano.
Published in: Comput Methods Programs Biomed, Issue Jan 21;230:107363, 2023, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2023.107363

A numerical study to investigate the effects of tumour position on the treatment of bladder cancer in mice using gold nanorods assisted photothermal ablation.

Author(s): Jason K. K. Cheong; Viktor Popov; Elisa Alchera; Irene Locatelli; Massimo Alfano; Luca Menichetti; Paolo Armanetti; Mirko Maturi; Mauro Comes Franchini; Ean H. Ooi; Yeong Shiong Chiew
Published in: Computers in Biology and Medicine, Issue 1, 2021, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104881

Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods

Author(s): Elisa Alchera, Matteo Monieri, Mirko Maturi, Irene Locatelli, Erica Locatelli, Silvia Tortorella, Angelina Sacchi, Angelo Corti, Manuela Nebuloni, Roberta Lucianò, Filippo Pederzoli, Francesco Montorsi, Andrea Salonia, Sandra Meyer, Jithin Jose, Pierangela Giustetto, Mauro Comes Franchini, Flavio Curnis, Massimo Alfano.
Published in: Photoacoustics, Issue 2022 Aug 30;28:100400. eCollection 2022 Dec., 2022, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2022.100400

Monographic books (2)

Multi-well Fibrillation Assay as a Tool for Analyzing Crosslinking and Stabilization of Collagen,

Author(s): V.R. Krishnaswamy, I Sagi
Published in: Methods Mol Biol, 2019, ISBN 1493990942
Publisher: Springer
DOI: 10.1007/978-1-4939-9095-5_2

Sample Preparation of Extracellular Matrix of Murine

Author(s): E. Shimshoni, I Sagi
Published in: Methods Mol Biol, Issue 1, 2019
Publisher: Springer
DOI: 10.1007/978-1-4939-9095-5_9