Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma.

Informations projet

EDIT

N° de convention de subvention: 801126

DOI

10.3030/801126

Projet clôturé

Date de signature de la CE 24 Mai 2018

Date de début 1 Octobre 2018

Date de fin 30 Septembre 2022

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 4 317 160,00

Contribution de l’UE

€ 4 317 160,00

Coordonné par

OSPEDALE SAN RAFFAELE SRL
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Demonstrators, pilots, prototypes (1)

Report on the development of machine learning algorithms.

Report on the development of machine learning algorithms

Websites, patent fillings, videos etc. (4)

At least 5 conferences and at least 3 peer-reviewed papers
Second plan for dissemination and exploitation for ( PUDF)
Workshop outside the consortium
Project website and logo

Documents, reports (5)

First plan for dissemination and exploitation (using and disseminating the foreground (=PUDF))

First plan for dissemination and exploitation (using and disseminating the foreground (=PUDF))

Final plan for using and disseminating the foreground (PUDF)

plan for using and disseminating the foreground PUDF

Report on novel biomarkers of bladder Cis
Report on the validation of the 3D visualization platform
PR3 - Agenda and Presentations

PR3 Agenda and Presentations for the preparation of the Periodic Review PR3 meeting

Publications

Peer reviewed articles (22)

The glycocalyx affects the mechanotransductive perception of the topographical microenvironment

Auteurs: Matteo Chighizola; Tania Dini; Stefania Marcotti; Mirko D’Urso; Claudio Piazzoni; Francesca Borghi; Anita Previdi; Laura Ceriani; Claudia Folliero; Brian Stramer; Cristina Lenardi; Paolo Milani; Alessandro Podestà; Carsten Schulte
Publié dans: Journal of Nanobiotechnology, Numéro 4, 2022, ISSN 1477-3155
Éditeur: BioMed Central
DOI: 10.1186/s12951-022-01585-5

A stapled chromogranin A-derived peptide homes in on tumors that express avb6 or avb8 integrins

Auteurs: Matteo Monieri, Paolo Rainone, Angelina Sacchi, Alessandro Gori, Anna Maria Gasparri, Angela Coliva, Antonio Citro, Benedetta Ferrara, Martina Policardi, Silvia Valtorta, Arianna Pocaterra, Massimo Alfano, Dean Sheppard, Lorenzo Piemonti, Rosa Maria Moresco, Angelo Corti, Flavio Curnis.
Publié dans: International Journal of Biological Sciences, Numéro 2023 VOLUME 19, 2023, Page(s) 156-166, ISSN 1449-2288
Éditeur: Ivyspring International Publisher
DOI: 10.7150/ijbs.76148

Causal contributors to tissue stiffness and clinical relevance in urology

Auteurs: Laura Martinez-Vidal, Valentina Murdica, Chiara Venegoni, Filippo Pederzoli, Marco Bandini, Andrea Necchi, Andrea Salonia, Massimo Alfano
Publié dans: Communications Biology, Numéro 4/1, 2021, Page(s) 1-16, ISSN 2399-3642
Éditeur: Springer Nature
DOI: 10.1038/s42003-021-02539-7

Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody

Auteurs: Lena Cohen, Irit Sagi, Einat Bigelman, Inna Solomonov, Anna Aloshin, Jeremy Ben-Shoshan, Zach Rozenbaum, Gad Keren, Michal Entin-Meer
Publié dans: PLOS ONE, Numéro 15/4, 2020, Page(s) e0231202, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0231202

An Application of Multivariate Data Analysis to Photoacoustic Imaging for the Spectral Unmixing of Gold Nanorods in Biological Tissues

Auteurs: Mirko Maturi, Paolo Armanetti, Luca Menichetti, Mauro Comes Franchini
Publié dans: Nanomaterials, Numéro 11/1, 2021, Page(s) 142, ISSN 2079-4991
Éditeur: RSC (Royal Chemical Society)
DOI: 10.3390/nano11010142

Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level

Auteurs: M. Chighizola, A. Previdi, T. Dini, C. Piazzoni, C. Lenardi, P. Milani, C. Schulte, A. Podestà
Publié dans: Nanoscale, Numéro 12/27, 2020, Page(s) 14708-14723, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0nr01991g

Distinct extracellular–matrix remodeling events precede symptoms of inflammation

Auteurs: Elee Shimshoni, Idan Adir, Ran Afik, Inna Solomonov, Anjana Shenoy, Miri Adler, Luca Puricelli, Fabio Sabino, Simonas Savickas, Odelia Mouhadeb, Nathan Gluck, Sigal Fishman, Lael Werner, Tomer-Meir Salame, Dror S. Shouval, Chen Varol, Ulrich auf dem Keller, Alessandro Podestà, Tamar Geiger, Paolo Milani, Uri Alon, Irit Sagi
Publié dans: Matrix Biology, Numéro 96, 2021, Page(s) 47-68, ISSN 0945-053X
Éditeur: Elsevier BV
DOI: 10.1016/j.matbio.2020.11.001

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

Auteurs: Mazor RD, Nathan N, Gilboa A, Stoler-Barak L, Moss L, Solomonov I, Hanuna A, Divinsky Y, Shmueli MD, Hezroni H, Zaretsky I, Mor M, Golani O, Sabah G, Jakobson-Setton A, Yanichkin N, Feinmesser M, Tsoref D, Salman L, Yeoshoua E, Peretz E, Erlich I, Cohen NM, Gershoni JM, Freund N, Merbl Y, Yaari G, Eitan R, Sagi I, Shulman Z.
Publié dans: Cell, Numéro 185 (7), 2022, Page(s) 1559-8985, ISSN 0082-1527
Éditeur: Cambridge, Massachusetts, United States
DOI: 10.1016/j.cell.2022.02.012

Stiffening of DU145 prostate cancer cells driven by actin filaments – microtubule crosstalk conferring resistance to microtubule-targeting drugs

Auteurs: Andrzej Kubiak, Matteo Chighizola, Carsten Schulte, Natalia Bryniarska, Julita Wesołowska, Maciej Pudełek, Małgorzata Lasota, Damian Ryszawy, Agnieszka Basta-Kaim, Piotr Laidler, Alessandro Podestà, Małgorzata Lekka
Publié dans: Nanoscale, Numéro 13/12, 2021, Page(s) 6212-6226, ISSN 2040-3364
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0nr06464e

Mechanotransduction in neuronal cell development and functioning

Auteurs: Matteo Chighizola, Tania Dini, Cristina Lenardi, Paolo Milani, Alessandro Podestà, Carsten Schulte
Publié dans: Biophysical Reviews, Numéro 11/5, 2019, Page(s) 701-720, ISSN 1867-2450
Éditeur: Springer Verlag
DOI: 10.1007/s12551-019-00587-2

Force sensing on cells and tissues by atomic force microscopy

Auteurs: Hatice Holuigue; Ewelina Lorenc; Matteo Chighizola; Carsten Schulte; Luca Varinelli; Marcello Deraco; Marcello Guaglio; Manuela Gariboldi; Alessandro Podestà
Publié dans: Sensors, Numéro 3, 2022, Page(s) 2197, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22062197

Current concepts in nanostructured contrast media development for in vivo photoacoustic imaging

Auteurs: Mirko Maturi, Erica Locatelli, Ilaria Monaco, Mauro Comes Franchini
Publié dans: Biomaterials Science, Numéro 7/5, 2019, Page(s) 1746-1775, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8bm01444b

Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression

Auteurs: Alakesh Das, Vishnu Mohan, Venkat Raghavan Krishnaswamy, Inna Solomonov, Irit Sagi
Publié dans: Cancer and Metastasis Reviews, 2019, Page(s) 455–468, ISSN 0072-7830
Éditeur: springer science & business media
DOI: 10.1007/s10555-019-09813-5

A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

Auteurs: Francesca Nardelli, Michela Ghitti, Giacomo Quilici, Alessandro Gori, Qingqiong Luo, Andrea Berardi, Angelina Sacchi, Matteo Monieri, Greta Bergamaschi, Wolfgang Bermel, Fuxiang Chen, Angelo Corti, Flavio Curnis, Giovanna Musco
Publié dans: Chemical Communications, 2019, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9cc08518a

MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

Auteurs: Mark Owyong, Jonathan Chou, Renske JE van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard, Dalit Talmi-Frank, Inna Solomonov, Charlotte Koopman, Elin Hadler-Olsen, Mark Headley, Charlene Lin, Chih-Yang Wang, Irit Sagi, Zena Werb, Vicki Plaks
Publié dans: Life Science Alliance, Numéro 2/6, 2019, Page(s) e201800226, ISSN 2575-1077
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.26508/lsa.201800226

LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis

Auteurs: Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi
Publié dans: Frontiers in Immunology, Numéro 11, 2020, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.00480

Influence of natural convection on gold nanorods-assisted photothermal treatment of bladder cancer in mice

Auteurs: Ean H. Ooi, Viktor Popov, Massimo Alfano, Jason K. K. Cheong
Publié dans: International Journal of Hyperthermia, Numéro 37/1, 2020, Page(s) 634-650, ISSN 0265-6736
Éditeur: Taylor & Francis
DOI: 10.1080/02656736.2020.1771437

Decellularized extracellular matrix as scaffold for cancer organoid cultures of colorectal peritoneal metastases

Auteurs: Luca Varinelli, Marcello Guaglio, Silvia Brich, Susanna Zanutto, Antonino Belfiore, Federica Zanardi, Fabio Iannelli, Amanda Oldani, Elisa Costa, Matteo Chighizola, Ewelina Lorenc, Simone P Minardi, Stefano Fortuzzi, Martina Filugelli, Giovanna Garzone, Federica Pisati, Manuela Vecchi, Giancarlo Pruneri, Shigeki Kusamura, Dario Baratti, Laura Cattaneo, Dario Parazzoli, Alessandro Podestà, Massimo
Publié dans: J. Molecular Cell Biology, Numéro mjac064, 2022, ISSN 1759-4685
Éditeur: Oxford University Press
DOI: 10.1093/jmcb/mjac064

Large colloidal probes for atomic force microscopy: Fabrication and calibration issues

Auteurs: Matteo Chighizola; Luca Puricelli; Ludovic Bellon; Alessandro Podestà
Publié dans: Journal of molecular recognition, Numéro 3, 2020, ISSN 0952-3499
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/jmr.2879

Gold nanorods assisted photothermal therapy of bladder cancer in mice: A computational study on the effects of gold nanorods distribution at the centre, periphery, and surface of bladder cancer

Auteurs: Jason Kk Cheong, Ean H Ooi, Yeong S Chiew , Luca Menichetti, Paolo Armanetti, Mauro Comes Franchini, Elisa Alchera, Irene Locatelli, Tamara Canu, Mirko Maturi, Viktor Popov, Massimo Alfano.
Publié dans: Comput Methods Programs Biomed, Numéro Jan 21;230:107363, 2023, ISSN 0169-2607
Éditeur: Elsevier BV
DOI: 10.1016/j.cmpb.2023.107363

A numerical study to investigate the effects of tumour position on the treatment of bladder cancer in mice using gold nanorods assisted photothermal ablation.

Auteurs: Jason K. K. Cheong; Viktor Popov; Elisa Alchera; Irene Locatelli; Massimo Alfano; Luca Menichetti; Paolo Armanetti; Mirko Maturi; Mauro Comes Franchini; Ean H. Ooi; Yeong Shiong Chiew
Publié dans: Computers in Biology and Medicine, Numéro 1, 2021, ISSN 0346-251X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104881

Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods

Auteurs: Elisa Alchera, Matteo Monieri, Mirko Maturi, Irene Locatelli, Erica Locatelli, Silvia Tortorella, Angelina Sacchi, Angelo Corti, Manuela Nebuloni, Roberta Lucianò, Filippo Pederzoli, Francesco Montorsi, Andrea Salonia, Sandra Meyer, Jithin Jose, Pierangela Giustetto, Mauro Comes Franchini, Flavio Curnis, Massimo Alfano.
Publié dans: Photoacoustics, Numéro 2022 Aug 30;28:100400. eCollection 2022 Dec., 2022, ISSN 2213-5979
Éditeur: Elsevier GmbH
DOI: 10.1016/j.pacs.2022.100400

Monographic books (2)

Multi-well Fibrillation Assay as a Tool for Analyzing Crosslinking and Stabilization of Collagen,

Auteurs: V.R. Krishnaswamy, I Sagi
Publié dans: Methods Mol Biol, 2019, ISBN 1493990942
Éditeur: Springer
DOI: 10.1007/978-1-4939-9095-5_2

Sample Preparation of Extracellular Matrix of Murine

Auteurs: E. Shimshoni, I Sagi
Publié dans: Methods Mol Biol, Numéro 1, 2019
Éditeur: Springer
DOI: 10.1007/978-1-4939-9095-5_9