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Nanoparticles-based 2D thermal bioimaging technologies

Deliverables

Cell temperature gradients report

Document describing in detail the first cell temperature imaging experiments during intracellular hyperthermia.

Basic model of energy transfer in nanocrystals

Report describing a basic microscopic model of energy transfer and luminescent processes in nanocrystals.

First generation of nanoparticles

Report describing the first generation of Ln3+- and TM-doped nanoparticles, with their basic structural, morphological and luminescence features.

Instruction manuals: first edition

First edition of two manuals of i) magnetic- and optically-induced heating optical microscope imaging and ii) magnetic- and optically-induced heating of cell cultures under temperature controlled conditions.

Dissemination and Exploitation Plan

Dissemination and Exploitation Plan

First calibration datasheets for in vivo imaging

Document describing the first calibration datasheets for the nanostructures to be used in in vivo 2D thermal imaging.

Powder-to-colloidal nanoparticles protocol

Protocol describing the synthesis methodology for developing colloidal NPs suitable for bio-applications in the NIR spectral region.

First round of nanoheaters and nanoplatforms

Selection of the first round of the most promising nanoheaters and nanoplatforms (up to 5 materials), including the description of the synthesis and the structural, morphological and optical properties.

Core-shell nanoparticles

Report on the synthesis conditions and on the structure and morphology of the materials to optimise the core-shell NPs architecture.

Report on the NPs functionalization

Report on the description of the functionalization procedure of distinct NPs and heater-thermometer nanostructures.

First report of in vivo detection of tumours

Report describing the design of in vivo experiments to study and monitor the thermal signatures caused by tumour development.

Web site and logo

NanoTBTech web site and logo. The web site will be continuously updated during the lifetime of the grant with news about the research results.

Leaflet

Production of a leaflet describing the NanoTBTech project, including the executive summary, the objectives, the partners and the potential project’ impact on future technologies.

Data Management Plan

Production of the data management plan.

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Publications

Lanthanide-Based Thermometers: At the Cutting-Edge of Luminescence Thermometry

Author(s): Carlos D. S. Brites, Sangeetha Balabhadra, Luís D. Carlos
Published in: Advanced Optical Materials, Issue Vol 7, issue 5,, 2019, Page(s) 1801239, ISSN 2195-1071
DOI: 10.1002/adom.201801239

In Vivo Contactless Brain Nanothermometry


Published in: ISSN 1616-301X
DOI: 10.1002/adfm.201806088

MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles

Author(s): Susana Carregal-Romero, Sandra Plaza-García, Rafael Piñol, José Murillo, Jesús Ruiz-Cabello, Daniel Padro, Angel Millán, Pedro Ramos-Cabrer
Published in: Biosensors, Issue 8/4, 2018, Page(s) 127, ISSN 2079-6374
DOI: 10.3390/bios8040127

Li 1 . 8 Na 0 . 2 Ti

Author(s): Milica Sekulić, Zoran Ristić, Bojana Milićević, Željka Antić, Vesna Đorđević, Miroslav D. Dramićanin
Published in: Optics Communications, Issue 452, 2019, Page(s) 342-346, ISSN 0030-4018
DOI: 10.1016/j.optcom.2019.07.056