Nanoparticles-based 2D thermal bioimaging technologies

Deliverables

Report on the second generation of hyperthermia experiments

Document describing the second generation of hyperthermia experiments and temperature gradients mapping in fresh slices and reconstituted collagen networks of tumors to observe the influence of local heating on the extracellular matrix and the tumour microenvironment

Report on the biodistribution and targeting capabilities of the nanostructures

Document describing the biodistribution and targeting capabilities of NPs and nanostructures

Cell temperature gradients report

Document describing in detail the first cell temperature imaging experiments during intracellular hyperthermia.

Model of heat dissipation and light propagation in nanothermometers

Report on the models used to describe the thermalization processes in and around the NPs to provide heat flow temporal and spatial information

Report on consortium's 2020 meeting

Report on the consortiums 2020 meeting including agenda list of participants and data presentations

Basic model of energy transfer in nanocrystals

Report describing a basic microscopic model of energy transfer and luminescent processes in nanocrystals.

Final report on the thermographic properties of NPs and nanostructures

Final report on the thermographic properties of materials developed in Tasks 1113 including their optical absorption excitation steady state and timeresolved emission q Sr thermal stability reproducibility of temperature readout and photothermal photoacoustic spectroscopy kinetics of heating and cooling features

Report on the 2-days workshop

Report on the two 2days workshop including agenda short CV and list of teachers and main training activities

Final calibration datasheets

Library of the final calibration datasheets for the nanostructures to be used in in vivo 2D thermal imaging

First generation of nanoparticles

Report describing the first generation of Ln3+- and TM-doped nanoparticles, with their basic structural, morphological and luminescence features.

Report on intracellular hyperthermia

Report on the effect of intracellular local hyperthermia in cell physiology and enhancement of the therapeutic effect of anticancer antibodies

Semiconductor colloidal nanothermometers

Report on the synthesis of the and characterization structural morphological and optical of colloidal nanothermometers

Instruction manuals: first edition

First edition of two manuals of i) magnetic- and optically-induced heating optical microscope imaging and ii) magnetic- and optically-induced heating of cell cultures under temperature controlled conditions.

Report on consortium's 2021 meeting

Report on the consortiums 2021 meeting including agenda list of participants and data presentations

Dissemination and Exploitation Plan
First calibration datasheets for in vivo imaging

Document describing the first calibration datasheets for the nanostructures to be used in in vivo 2D thermal imaging.

Ln3+- and TM-doped nanothermometers

Report on the structure and characterization of up to 5 most promising selected Ln3 and TMdoped nanothermometers

Final report on in vivo detection of tumours

Document describing all the in vivo experiments performed including a clinical score therapeutic efficiency pharmacokinetics biodistribution and excretion of the NPs ex vivo

Report on the cytotoxicity of the NPs and nanostructures

Document describing initial result of the cytotoxicity of the NPs and nanostructures evaluated on different cell lines and taking into account the influence of the coating concentration and incubating time

Report on the thermographic properties of NPs and nanostructures

First report on the description of the thermographic properties of the nanomaterials developed in Tasks 1113

Final report on functionalization and dispersion of the nanostructures

Document describing the complete procedure for the functionalization and dispersion of NPs and nanostructures including the use of antibodies to target EGFRoverexpressing cancer cells for magnetic or optical hyperthermia therapy

Powder-to-colloidal nanoparticles protocol

Protocol describing the synthesis methodology for developing colloidal NPs suitable for bio-applications in the NIR spectral region.

Report on first hyperthermia experiments

Document describing the first hyperthermia experiments and temperature gradients mapping in fresh slices and reconstituted collagen networks of tumors to observe the influence of local heating on the extracellular matrix and the tumour microenvironment

Report of the industrial workshop

Report on the industrial workshop including agenda short CV and list of teachers and main training activities

Second generation of colloidal semiconductor nanoparticles

Second generation of colloidal NPs suitable for bioapplications in the NIR spectral region

Improved model of light propagation in tissues

Report on improved models capable of reproducing measured temperature patterns and light propagation profiles in tissues for general use Results and predictions from modelling will be verifiedcompared to experimental results obtained in specially developed phantom tissues

Improved model of heat processes in nanothermometers

Report on a improved model of heat processes in nanocrystals The model will be capable of a quantitatively meaningful prediction on heat transfer in vivo systems that will be tested in WP6

Cell temperature imaging final report

Document describing in detail the cell temperature imaging experiments during intracellular hyperthermia using NPs functionalized with antibodies and including teh experiments with macrophages

Model of light propagation in tissues

Report describing the first attempts to model light propagation in biological tissues including the description of the absorption and scattering processes to predict the penetration depth and spatial resolution

First round of nanoheaters and nanoplatforms

Selection of the first round of the most promising nanoheaters and nanoplatforms (up to 5 materials), including the description of the synthesis and the structural, morphological and optical properties.

Second round of nanoheaters and heater-thermometer nanostructures

Report on the synthesis procedures and general characterization structural morphological thermal magnetic and optical for the design of the second round of heaterthermometer nanostructures

Core-shell nanoparticles

Report on the synthesis conditions and on the structure and morphology of the materials to optimise the core-shell NPs architecture.

Toxicity assessment library

Document listed all the mechanisms and the transformation kinetic of the degraded nanoproducts to assess the potential toxicity of the nanostructures

Second generation of Ln3+- and TM-doped nanoparticles

Report describing the second generation of Ln3 and TMdoped nanoparticles with their basic structural morphological and luminescence features

Second report of in vivo detection of tumours

Report describing the design and the development of in vivo experiments to study and monitor the thermal signatures caused by tumour development The heatingsensing nanostructures will be incorporated into tumours and a magnetic field or light pulse will be applied with the subsequent monitoring of the thermal relaxation dynamics

Report on the NPs functionalization

Report on the description of the functionalization procedure of distinct NPs and heater-thermometer nanostructures.

Small imaging system manuals

Small imaging system manuals 2 for hyperthermia performance and thermal relaxation of deep tissue tumours

First report of in vivo detection of tumours

Report describing the design of in vivo experiments to study and monitor the thermal signatures caused by tumour development.

Improved model of energy transfer processes

Report on a improved model of energy transfer processes in nanocrystals The model will be capable of explaining and predicting optimum dopant concentrations identifying teh main energy loss mechanisms

Instruction manuals: final edition

Final edition of two manuals of i magnetic and opticallyinduced heating optical microscope imaging and ii magnetic and opticallyinduced heating of cell cultures under temperature controlled conditions

Web site and logo

NanoTBTech web site and logo. The web site will be continuously updated during the lifetime of the grant with news about the research results.

Leaflet

Production of a leaflet describing the NanoTBTech project, including the executive summary, the objectives, the partners and the potential project’ impact on future technologies.

Software for fluorescence and hyperspectral images

Software module for control of the fluorescence images and realtime analysis of hyperspectral metafiles for deep tissuewhole body imaging

Data Management Plan

Production of the data management plan.

Publications

A Ho3+‐Based Luminescent Thermometer for Sensitive Sensing over a Wide Temperature Range

Author(s): van Swieten, T. P., Yu, D., Yu, T., Vonk, S. J. W., Suta M., Zhang, Q., Meijerink, A., & Rabouw, F. T.
Published in: Advanced Optical Materials, Issue 9, 2021, Page(s) 2001518, ISSN 2195-1071
Publisher: Willey
DOI: 10.1002/adom.202001518

Visible and NIR Upconverting Er 3+ –Yb 3+ Luminescent Nanorattles and Other Hybrid PMO‐Inorganic Structures for In Vivo Nanothermometry

Author(s): Anna M. Kaczmarek, Markus Suta, Hannes Rijckaert, Anatolii Abalymov, Isabel Van Driessche, Andre G. Skirtach, Andries Meijerink, Pascal Van Der Voort
Published in: Advanced Functional Materials, Issue 30/32, 2020, Page(s) 2003101, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202003101

Ga-Modified YAG:Pr3+ Dual-Mode Tunable Luminescence Thermometers

Author(s): Paulina Bolek; Justyna Zeler; Carlos D.S. Brites; Joanna Trojan-Piegza; Luís D. Carlos; Eugeniusz Zych
Published in: Chemical Engineering Journal, Issue 421, 2021, Page(s) 129764, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.5281/zenodo.6202310

Nanoprobes for Biomedical Imaging with Tunable Near-Infrared Optical Properties Obtained via Green Synthesis

Author(s): Riccardo Marin; Antonio Benayas; Nuria García-Carillo; José Lifante; Jingke Yao; Diego Mendez-Gonzalez; Francisco Sanz-Rodríguez; Jorge Rubio-Retama; Lucas V. Besteiro; Daniel Jaque
Published in: Advanced Photonics Research, Issue 3, 2021, Page(s) 2100260, ISSN 2699-9293
Publisher: Wiley Open Access
DOI: 10.1002/adpr.202100260

A hybrid materials approach for fabricating efficient WLEDs based on di-ureasils doped with carbon dots and a europium complex

Author(s): Ming Fang; Albano N. Carneiro Neto; Lianshe Fu; Rute A. S. Ferreira; Verónica de Zea Bermudez; Luís. D. Carlos
Published in: Advanced Materials Technology, Issue 2100727, 2021, ISSN 2365-709X
Publisher: Wiley
DOI: 10.1002/admt.202100727

Doping Lanthanide Ions in Colloidal Semiconductor Nanocrystals for Brighter Photoluminescence

Author(s): Marin R. & Jaque, D.
Published in: Chemical Reviews, Issue 121, 2021, Page(s) 1425–1462, ISSN 1520-6890
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.0c00692

Controlling the Thermal Switching in Upconverting Nanoparticles Through Surface Chemistry

Author(s): Eduardo D. Martínez; Alí F. García-Flores; Albano N. Carneiro Neto; Carlos D. S. Brites; Luís D. Carlos; Ricardo R. Urbano; Carlos Rettori
Published in: Nanoscale, Issue 13, 2021, Page(s) 16267–16276, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr03223b

Quo Vadis, Nanoparticle-Enabled In Vivo Fluorescence Imaging?

Author(s): Erving Ximendes; Antonio Benayas; Daniel Jaque; Riccardo Marin
Published in: ACS Nano, Issue 15, 2021, Page(s) 1917–1941, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c08349

Self-Assemblies of Fe3O4 Nanocrystals: Toward Nanoscale Precision of Photothermal Effects in theTumor Microenvironment

Author(s): Nicolas-Boluda, A., Yang, Z., Guilbert, T., Fouassier, L., Carn, F., Gazeau, F. & Pileni, M.P.
Published in: Advanced Functional Materials, Issue 31, 2021, Page(s) 2006824,, ISSN 1616-3028
Publisher: Wiley
DOI: 10.1002/adfm.202006824

A Theoretical Framework for Ratiometric Single Ion Luminescent Thermometers—Thermodynamic and Kinetic Guidelines for Optimized Performance

Author(s): Markus Suta; Andries Meijerink
Published in: Advanced Theory and Simulations, Issue 3 (12), 2020, Page(s) 2000176, ISSN 2513-0390
Publisher: Wiley
DOI: 10.1002/adts.202000176

The role of tissue fluorescence in in vivo optical bioimaging

Author(s): José Lifante; Yingli Shen; Erving Ximendes; Emma Martín Rodríguez; Dirk H. Ortgies
Published in: Journal of Applied Physics, Issue 128, 2020, Page(s) 171101, ISSN 1089-7550
Publisher: American Institute of Physics
DOI: 10.5281/zenodo.5793672

From structural phase transition to highly sensitive lifetime based luminescent thermometer: multifaceted modification of thermometric performance in Y0.9-xNdxYb0.1PO4 nanocrystals

Author(s): Maciejewska, Kamila; Szalkowski, Marcin; Bednarkiewicz, Artur; Marciniak, Łukasz
Published in: Journal of Materials Chemistry C, Issue 9, 2021, Page(s) 15831–15839, ISSN 2050-7526
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tc04107j

Effect of superparamagnetic iron oxide nanoparticles on glucose homeostasis on type 2 diabetes experimental model

Author(s): Lamiaa M. A. Ali; Lamiaa M. A. Ali; Sara A. Shaker; Rafael Piñol; Ángel Millán; Mervat Youssef Hanafy; Madiha H. Helmy; Maher A. Kamel; Shimaa A. Mahmoud
Published in: Life Sciences, Issue 245, 2020, Page(s) 117361, ISSN 0024-3205
Publisher: Elsevier BV
DOI: 10.1016/j.lfs.2020.117361

Structurally induced tuning of the relative sensitivity of LaScO3:Cr3+ luminescent thermometers by co-doping lanthanide ions

Author(s): Elzbieciak-Piecka, Karolina; Suta, Markus; Marciniak, Lukasz
Published in: Chemical Engineering Journal, Issue 421, 2021, Page(s) 129757, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2021.129757

Surface Plasmon Enhancement of Eu3+ Emission Intensity in LaPO4/Ag Nanoparticles.

Author(s): Sanja Kuzman; Jovana Periša; Vesna Đorđević; Ivana Zeković; Ivana Vukoje; Željka Antić; Miroslav D. Dramićanin
Published in: Materials, Issue 13, 2020, Page(s) 3071, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.5281/zenodo.4809156

NIR luminescence lifetime nanothermometry based on phonon assisted Yb3+–Nd3+ energy transfer

Author(s): Kamila Maciejewska; Artur Bednarkiewicz; Lukasz Marciniak
Published in: Nanoscale Advances, Issue 4, 2021, Page(s) 3, 4918-4925, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1na00285f

Unexpected intracellular biodegradation and recrystallization of gold nanoparticles

Author(s): Balfourier, A., Luciani, N., Wang, G., Lelong, G., Ersen, O., Khelfa, A., Alloyeau, D., Gazeau, F. & Carn, F.,
Published in: PNAS 2020, Issue 117, 2020, Page(s) 103-113,, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1911734116

Rationalizing the Thermal Response of Dual-Center Molecular Thermometers: The Example of an Eu/Tb Coordination Complex

Author(s): Carneiro Neto, A.N., Mamontova, E., Botas, A.M.P., Brites, C.D.S., Ferreira, R.A.S., Rouquette, J., Guari, Y., Larionova, J., Long, J. & Carlos, L.D.
Published in: Advanced Optical Material, Issue 10, 2022, Page(s) 2101870, ISSN 2195-1071
Publisher: Wiley
DOI: 10.1002/adom.202101870

Luminescence based temperature bio-imaging: the status, challenges and perspectives

Author(s): Bednarkiewicz, A., Drabik, J., Trejgis, K., Jaque D., Ximendes E. & Marciniak L.
Published in: Applied Physics Reviews, Issue 8, 2021, Page(s) 011317, ISSN 1931-9401
Publisher: AIP Publishing LLC
DOI: 10.1063/5.0030295

Real-Time Intracellular Temperature Imaging Using Lanthanide-Bearing Polymeric Micelles.

Author(s): Rafael Piñol; Justyna Zeler; Justyna Zeler; Carlos D. S. Brites; Yuanyu Gu; Yuanyu Gu; P. Tellez; Albano N. Carneiro Neto; Thiago E. da Silva; Thiago E. da Silva; Raquel Moreno-Loshuertos; Patricio Fernández-Silva; Ana Isabel Gallego; Luis Martínez-Lostao; A. Martinez; Luís D. Carlos; Ángel Millán
Published in: Nano Letters, Issue 20, 2020, Page(s) 6466–6472, ISSN 1530-6992
Publisher: ACS Publications
DOI: 10.5281/zenodo.4034612

Thermal enhancement of upconversion emission in nanocrystals: a comprehensive summary

Author(s): Rui Shi; Eduardo D. Martinez; Carlos D. S. Brites; Luís D. Carlos
Published in: Physical Chemistry Chemical Physics, Issue 23, 2021, Page(s) 20-42, ISSN 1463-9084
Publisher: Royal Society of Chemistry
DOI: 10.5281/zenodo.6199409

Structural and luminescent properties of Y2Mo4O15: Eu3+ red phosphor calcined at different temperatures

Author(s): Papan, Jelena; Ristić, Zoran; Ćirić, Aleksandar; Kuzman, Sanja; Dramićanin, Miroslav D.
Published in: Physica Status Solidi B, Issue 257, 2020, Page(s) 1900454, ISSN 1521-3951
Publisher: Wiley
DOI: 10.5281/zenodo.5011213

Electrochromic Switch Devices Mixing Small‐ and Large‐Sized Upconverting Nanocrystals

Author(s): Martínez, Eduardo D.; Brites, Carlos D. S.; Carlos, Luís D.; García-Flores, Alí F.; Urbano, Ricardo R.; Rettori, Carlos
Published in: Advanced Functional Materials, Issue 29, 2019, Page(s) 1807758, ISSN 1616-3028
Publisher: Wiley-VCH Verlag
DOI: 10.5281/zenodo.5013844

Mixing Phosphors to Improve the Temperature Measuring Quality

Author(s): Paulina Bolek; Justyna Zeler; Luís D. Carlos; Eugeniusz Zych
Published in: Optical Materials, Issue 122, 2021, Page(s) 111719, ISSN 0925-3467
Publisher: Elsevier BV
DOI: 10.1016/j.optmat.2021.111719

JOYSpectra: a web platform for luminescence of lanthanides

Author(s): Renaldo T. Moura Jr.; Albano N. Carneiro Neto; Eduardo C. Aguiar; Carlos V. Santos-Jr.; Ewerton M. de Lima; Wagner M. Faustino; Ercules E. S. Teotonio; Hermi F. de Brito; Maria C.F.C. Felinto; Rute A. S. Ferreira; Luís D. Carlos; Ricardo L. Longo; Oscar L. Malta
Published in: Optical Materials, Issue 11, 2021, Page(s) 100080, ISSN 0925-3467
Publisher: Elsevier BV
DOI: 10.1016/j.omx.2021.100080

Rational Design of Fractal Gold Nanosphere Assemblies with Optimized Photothermal Conversion Using a Quantitative Structure Property Relationship (QSPR) Approach

Author(s): Alice Balfourier; Vladimir Mulens-Arias; Florence Gazeau; Florent Carn
Published in: Journal of Physical Chemistry C, Issue 124, 2020, Page(s) 8938-8948, ISSN 1932-7447
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcc.0c00384

Autofluorescence-Free in Vivo Imaging Using Polymer-Stabilized Nd3+-Doped YAG Nanocrystals

Author(s): Alexandra Cantarano, Jingke Yao, Marija Matulionyte, José Lifante, Antonio Benayas, Dirk Ortgies, Fiorenzo Vetrone, Alain Ibanez, Corine Gerardin & Daniel Jaque
Published in: ACS Applied Materials & Interfaces, Issue 12, 2020, Page(s) 51273-51284, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c15514

Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging

Author(s): Harrisson D. A. Santos, Irene Zabala Gutiérrez, Yingli Shen, José Lifante, Erving Ximendes, Marco Laurenti, Diego Méndez-González, Sonia Melle, Oscar G. Calderón, Enrique López Cabarcos, Nuria Fernández, Irene Chaves-Coira, Daniel Lucena-Agell, Luis Monge, Mark D. Mackenzie, José Marqués-Hueso, Callum M. S. Jones, Carlos Jacinto, Blanca del Rosal, Ajoy K. Kar, Jorge Rubio-Retama, Daniel J
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16333-2

Efficient Brownian oscillator and nanoheaters based on Gallium-doped e-Fe2O3

Author(s): Gu, Y., Silva, N. J. O., Yoshikiyo, M., Namai, A., Piñol, R., Maurin-Pasturel, G., Cui, Y., Ohkoshi, S., Millán, A. & Martínez, A.
Published in: Chemical Communications, Issue 57, 2021, Page(s) 22852288, ISSN 1364-548X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc07309a

Standardizing luminescence nanothermometry for biomedical applications

Author(s): Artur Bednarkiewicz, Lukasz Marciniak, Luís D. Carlos, Daniel Jaque
Published in: Nanoscale, Issue 20, 2020, Page(s) 14405, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr03568h

Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations.

Author(s): José Lifante; Yingli Shen; Irene Zabala Gutierrez; Irene Rubia-Rodríguez; Daniel Ortega; Daniel Ortega; Nuria Fernández; Sonia Melle; Miriam Granado; Jorge Rubio-Retama; Daniel Jaque; Erving Ximendes
Published in: Advanced Science, Vol 8, Iss 9, Pp n/a-n/a (2021), Issue 8, 2021, Page(s) 2003838, ISSN 1931-9401
Publisher: AIP Publishing LLC
DOI: 10.1002/advs.202003838

Switching to the brighter lane: pathways to boost the absorption of lanthanide-doped nanoparticles

Author(s): Riccardo Marin and Daniel Jaque
Published in: Chemical Reviews, Issue 121, 2021, Page(s) 1425–1462, ISSN 1520-6890
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.0c00692

One ion to catch them all: Targeted high-precision Boltzmann thermometry over a wide temperature range with Gd3+.

Author(s): Dechao Yu, Huaiyong Li, Dawei Zhang, Qinyuan Zhang, Andries Meijerink, Markus Suta
Published in: Light: Science and Applications, Issue 10, 2021, Page(s) 236, ISSN 2047-7538
Publisher: Springer Nature
DOI: 10.1038/s41377-021-00677-5

Ag2S nanoheaters with multiparameter sensing for reliable thermal feedback during in vivo tumor therapy

Author(s): Yingli Shen, Harrisson D. A. Santos, Erving C. Ximendes, José Lifante, Ana Sanz-Portilla, Luis Monge, Nuria Fernández, Irene Chaves-Coira, Carlos Jacinto, Carlos D. S. Brites, Luís D. Carlos, Antonio Benayas, M. Carmen Iglesias-de la Cruz, Daniel Jaque
Published in: Advanced Functional Materials, Issue 30, 2020, Page(s) 2002730, ISSN 1616-3028
Publisher: Wiley Online Library
DOI: 10.1002/adfm.202002730

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma

Author(s): Nicolás-Boluda, A., Vaquero, J., Laurent, G., Renault, G., Bazzi, R., Donnadieu, E., Roux, S., Fouassier, L. & Gazeau, F.
Published in: ACS Nano, Issue 14, 2020, Page(s) 5738–5753, ISSN 1936-086X
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c00417

Advances and challenges for fluorescence nanothermometry

Author(s): Zhou J; Del Rosal B; Jaque D; Uchiyama S; Jin D
Published in: Nature Methods, Issue 17, 2020, Page(s) 967–980, ISSN 1548-7105
Publisher: Nature Research
DOI: 10.5281/zenodo.4630946

The effects of dopant concentration and excitation intensity on the upconversion and downconversion emission processes of β-NaYF4:Yb3+,Er3+ nanoparticles

Author(s): Vivian Torres Vera, Diego Mendez-Gonzalez, Diego J. Ramos-Ramos, Asmae Igalla, Marco Laurenti, Rafael Contreras-Caceres, Enrique Lopez-Cabarcos, Elena Díaz, Jorge Rubio-Retama, Sonia Melle, Oscar G. Calderón
Published in: Journal of Materials Chemistry C, Issue 9, 2021, Page(s) 8902-8911, ISSN 2050-7526
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tc01419f

Plasmonic Copper Sulde Nanoparticles Enable Dark Contrast in Optical Coherence Tomography

Author(s): Marin, R., Lifante, J., Besteiro, L. V., Wang, Z., Govorov, A. O., Rivero F., Alfonso F., Sanz-Rodríguez F. & Daniel Jaque D.,
Published in: Advanced Healthcare Materials, Issue 9, 2020, Page(s) 1901627, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.201901627

Correlation between the Covalenty and the thermometric properties of YB3+/Er3+ Codoped Nanocrystalline Orthophosphates

Author(s): Maciejewska, K., Bednarkiewicz, A., Meijerink, A. & Marciniak, L.
Published in: Journal of Physical Chemistry C, Issue 125,, 2021, Page(s) 2659−2665, ISSN 1932-7455
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcc.0c09532

In Vivo Spectral Distortions of Infrared Luminescent Nanothermometers Compromise Their Reliability

Author(s): Yingli Shen; José Lifante; Nuria Fernández; Daniel Jaque; Erving Ximendes
Published in: ACS Nano, Issue 14, 4, 2020, Page(s) 4122-4133, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b08824

Standardization of Methodology of Light-to-Heat Conversion Efficiency Determination for Colloidal Nanoheaters

Author(s): Pasciak, A.,Pilch-Wróbel, A., Marciniak, L., Schuck, J. P., & Bednarkiewicz, A.
Published in: ACS Applied Materials and Interfaces, Issue 13, 2021, Page(s) 44556-44567, ISSN 1944-8252
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c12409

In vivo near-infrared imaging using ternary selenide semiconductor nanoparticles with uncommon crystal structure

Author(s): Jingke Yao; José Lifante; Paloma Rodríguez; María de la Fuente-Fernández; Francisco Sanz-Rodríguez; Dirk H. Ortgies; Erving Ximendes; Daniel Jaque; Riccardo Marin
Published in: Small, Issue 2, 2021, ISSN 1613-6829
Publisher: Small
DOI: 10.1002/smll.202103505

Tumor-selective immune-active mild hyperthermia associated with chemotherapy in colon peritoneal metastasis by photoactivation of fluorouracil-gold nanoparticle complexes

Author(s): Mulens-Arias, V., Nicolás-Boluda, A., Pinto, A., Balfourier, A., Carn, F., Silva, A.K.A., Pocard, M. & Gazeau, F.
Published in: ACS Nano, Issue 15, 2021, Page(s) 3330-3348, ISSN 1936-086X
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c10276

Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia

Author(s): Nicolas-Boluda, A., Laurent, G., Bazzi R., Roux, S., Donnadieu, E. & Gazeau F.
Published in: Nanoscale, Issue 13, 2021, Page(s) 18483-18497, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr03201a

Accurate In Vivo Nanothermometry through NIR-II Lanthanide Luminescence Lifetime

Author(s): Meiling Tan; Feng Li; Ning Cao; Hui Li; Xin Wang; Chenyang Zhang; Daniel Jaque; Guanying Chen
Published in: Small, Issue 16, 2020, Page(s) 2004118, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/smll.202004118

In Vivo Near-Infrared Imaging Using Ternary Selenide Semiconductor Nanoparticles with anUncommon Crystal Structure

Author(s): Ximendes, E., Marin, R., Shen, Y., Ruiz, D., Gómez-Cerezo, D., Rodríguez-Sevilla, P., Lifante, J.,Viveros-Méndez, P.X., Gámez, F., García-Soriano, D., Salas, G., Zalbidea, C., Espinosa, A., Benayas, A., García-Carrillo, N., Cussó, L., Desco, M., Teran, F.J., Juárez, B.H. & Jaque, D.
Published in: Advanced Materials, Issue 33, 2021, Page(s) 2100077, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/adma.202100077

Thermal properties of lipid bilayers derived from the transient heating regime of upconverting nanoparticles

Author(s): Ana R. N. Bastos; Carlos D.S. Brites; Paola A. Rojas-Gutierrez; Rute A.S. Ferreira; Ricardo L. Longo; Christine DeWolf; John A. Capobianco; Luís D. Carlos
Published in: 24169, Nanoscale, (2020), Issue 12, 2020, Page(s) 24169, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr06989b

Investigation of the concentration- and temperature-dependent motion of colloidal nanoparticles.

Author(s): Barnaby Handel; Vladislava Vladimirova Dinkova; Erving Ximendes; José García Solé; Daniel Jaque; Riccardo Marin
Published in: Nanoscale, Issue 12, 2020, Page(s) 12561-12567, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr02995e

Magnetic hyperthermia with ε-Fe2O3 nanoparticles

Author(s): Yuanyu Gu; Yuanyu Gu; Marie Yoshikiyo; Asuka Namai; Debora Bonvin; A. Martinez; Rafael Piñol; P. Tellez; Nuno Silva; Fredrik Ahrentorp; Christer Johansson; Joaquín Marco-Brualla; Raquel Moreno-Loshuertos; Patricio Fernández-Silva; Yuwen Cui; Shin-ichi Ohkoshi; Ángel Millán
Published in: RSC Advances, Issue 10, 2020, Page(s) 28786, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ra04361c

Near infrared bioimaging and biosensing with semiconductor and rare-earth nanoparticles: recent developments in multifunctional nanomaterials

Author(s): Artiom Skripka; Diego Mendez-Gonzalez; Riccardo Marin; Erving Ximendes; Blanca del Rosal; Daniel Jaque; Paloma Rodríguez-Sevilla
Published in: Nanoscale Advances, Issue 3, 2021, Page(s) 6310, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1na00502b

The influence of Ce3+ codoping and excitation scheme on spectroscopic properties of NaYF4:Yb3+,Ho3+

Author(s): Aleksandra Pilch-Wróbel, Joanna Zasada, Artur Bednarkiewicz
Published in: Journal of Luminescence, Issue 226, 2020, Page(s) 117494, ISSN 0022-2313
Publisher: Elsevier BV
DOI: 10.1016/j.jlumin.2020.117494

Lanthanide doped nanoheaters with reliable and absolute temperature feedback

Author(s): López-Peña, G., Hamraoui, K., Horchani-Naifer, K., Gerke, C., Ortgies, D.H., Rodríguez, E.M., Chen, G., Jaque, D., & Rubio, J.R.
Published in: Physica B: Condensed Matter, Issue 631, 2022, Page(s) 413652, ISSN 0921-4526
Publisher: Elsevier BV
DOI: 10.1016/j.physb.2021.413652

Comparison of Three Ratiometric Temperature Readings from the Er3+ Upconversion Emission

Author(s): Ćirić, Aleksandar; Aleksić, Jelena; Barudžija, Tanja; Antić, Željka; Đorđević, Vesna; Medić, Mina; Periša, Jovana; Zeković, Ivana; Mitrić, Miodrag; Dramićanin, Miroslav D.
Published in: Nanomaterials, Issue Vol 10, Iss 627, 2020, Page(s) 627, ISSN 2079-4991
Publisher: MDPI
DOI: 10.5281/zenodo.3899751

Upconverting Nanoparticles in Aqueous Media: Not a Dead-End Road. Avoiding Degradation by Using Hydrophobic Polymer Shells

Author(s): Mendez-Gonzalez, Diego; Vera, Vivian Torres; Gutierrez, Irene Zabala; Cascales, Concepción; Rubio-Retama, Jorge; Calderón, Oscar G.; Melle, Sonia; Laurenti, Marco
Published in: Small, Issue 2105652, 2021, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/smll.202105652

Experimental measurement of local high temperature at the surface of gold nanorods using doped ZnGa2O4 as a nanothermometer

Author(s): Estelle Glais, Agnès Maître, Bruno Viana, Corinne Chanéac
Published in: Nanoscale Advances, Issue 3, 2021, Page(s) 2862-2869, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1na00010a

Hyperspectral imaging thermometry assisted by upconverting nanoparticles: Experimental artifacts and accuracy

Author(s): Martínez, E.D., Brites, C.D.S., Urbano, R.R.,Rettori, C. & Carlos, L.D.
Published in: Physica B: Condensed Matter, Issue 629, 2022, Page(s) 413639, ISSN 0921-4526
Publisher: Elsevier BV
DOI: 10.1016/j.physb.2021.413639

High temperature (nano)thermometers based on LiLuF4:Er3+,Yb3+ nano- and microcrystals. Confounded results for core–shell nanocrystals

Author(s): Kaczmarek, Anna M.; Suta, Markus; Rijckaert, Hannes; van Swieten, Thomas P.; Van Driessche, Isabel; Kaczmarek, Mariusz K.; Meijerink, Andries
Published in: Journal of Materials Chemistry C, Issue 9, 2021, Page(s) 3589, ISSN 2050-7526
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0tc05865c

Lanthanide-Based Thermometers: At the Cutting-Edge of Luminescence Thermometry

Author(s): Carlos D. S. Brites, Sangeetha Balabhadra, Luís D. Carlos
Published in: Advanced Optical Materials, Issue Vol 7, issue 5,, 2019, Page(s) 1801239, ISSN 2195-1071
Publisher: Wiley Online Library
DOI: 10.1002/adom.201801239

In Vivo Contactless Brain Nanothermometry

Author(s): Blanca del Rosal, Diego Ruiz, Irene Chaves-Coira, Beatriz H. Juárez, Luis Monge, Guosong Hong, Nuria Fernández, Daniel Jaque
Published in: Advanced Functional Materials, Issue 28/52, 2018, Page(s) 1806088, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201806088

MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles

Author(s): Susana Carregal-Romero, Sandra Plaza-García, Rafael Piñol, José Murillo, Jesús Ruiz-Cabello, Daniel Padro, Angel Millán, Pedro Ramos-Cabrer
Published in: Biosensors, Issue 8/4, 2018, Page(s) 127, ISSN 2079-6374
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios8040127

Li 1 . 8 Na 0 . 2 Ti

Author(s): Milica Sekulić, Zoran Ristić, Bojana Milićević, Željka Antić, Vesna Đorđević, Miroslav D. Dramićanin
Published in: Optics Communications, Issue 452, 2019, Page(s) 342-346, ISSN 0030-4018
Publisher: Elsevier BV
DOI: 10.1016/j.optcom.2019.07.056

Ratiometric temperature measurement using negative thermal quenching of intrinsic BiFeO <sub>3</sub> semiconductor nanoparticles

Author(s): Antić, Željka; Prashanthi, K.; Kuzman, Sanja; Periša, Jovana; Ristić, Zoran; Palkarc, V. R.; Dramićanin, Miroslav D.
Published in: RSC Advances, Issue 10, 2020, Page(s) 16982, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ra01896a

Reliable and Remote Monitoring of Absolute Temperature During Liver Inflammation via Luminescence Lifetime-Based Nanothermometry

Author(s): Shen, Y., Lifante, J., Gutierrez, I.Z., Fuente-Fernández, M., Granado, M., Fernández N., Rubio-Retama J., Jaque D., Marin R., Ximendes E., & Benayas A.
Published in: Advanced Materials, Issue 2107764, 2022, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/adma.202107764

3D sub-cellular localization of upconverting nanoparticles through hyperspectral microscopy

Author(s): Silva, R.N., Botas, A.M.P., Brandão, D., Bastos, V., Oliveira, H., Debasu, M.L., Ferreira, R.A.S., Brites, C.D.S., & Carlos, L.D.
Published in: Physica B: Condensed Matter, Issue 626, 2022, Page(s) 413470, ISSN 0921-4526
Publisher: Elsevier BV
DOI: 10.1016/j.physb.2021.413470

Going Above and Beyond: A Tenfold Gain in the Performance of Luminescence Thermometers Joining Multiparametric Sensing and Multiple Regression

Author(s): Maturi, F. E., Brites, C. D. S., Ximendes, E. C., Mills, C., Olsen, B., Jaque D., Ribeiro, S. J. L. & Carlos, L. D.
Published in: Laser Photonics Reviews, Issue 15, 2021, Page(s) 2100301, ISSN 1863-8899
Publisher: Wiley-VCH Verlag
DOI: 10.1002/lpor.202100301

Boosting the Near-Infrared Emission of Ag2S Nanoparticles by a Controllable Surface Treatment for Bioimaging Applications

Author(s): Gutierrez, I.Z., Gerke C., Shen, Y., Ximendes, E., Silvan, M.M., Marin, R., Jaque, D., Calderón, O.G., Melle, S. & Rubio-Retama, J.
Published in: ACS Applied Materials and Interfaces, Issue 14, 2022, Page(s) 4871 - 4881, ISSN 1944-8252
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c19344

Molecular Imaging of Infarcted Heart by Biofunctionalized Gold Nanoshells.

Author(s): Tamara Muñoz-Ortiz; Jie Hu; Dirk H. Ortgies; Shreya Shrikhande; Paula Zamora-Perez; Miriam Granado; Daniel González-Hedström; María de la Fuente-Fernández; Angel Luis García-Villalón; Laura Andrés-Delgado; Emma Martín Rodríguez; Rio Aguilar; Fernando Alfonso; José García Solé; Pilar Rivera Gil; Daniel Jaque; Fernando Rivero
Published in: Advanced Healthcare Materials, Issue 10, 2021, Page(s) 2002186, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202002186

Spectral and thermometric properties altering through crystal field strength modification and host material composition in luminescent thermometers based on Fe3+ doped AB2O4 type nanocrystals (A= Mg, Ca; B=Al, Ga)

Author(s): K.Kniec; W. Piotrowski; K. Ledwa; L. D. Carlos; L. Marciniak
Published in: Journal of Materials Chemistry C, Issue 9, 2021, Page(s) 517, ISSN 2050-7496
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0tc04917d

One ion, many facets: Efficient, structurally and thermally sensitive luminescence of Eu2+ in binary and ternary strontium borohydride chlorides

Author(s): Wylezich, Thomas; Sontakke, Atul D.; Castaing, Victor; Suta, Markus; Viana, Bruno; Meijerink, Andries; Kunkel, Nathalie
Published in: Chemistry of Materials, 8957, Issue 9, 2019, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.5281/zenodo.3748960

Decoding a Percolation Phase Transition of Water at ∼330 K with a Nanoparticle Ruler

Author(s): Brites, Carlos D. S.; Bilin Zhuang; Mengistie L. Debasu; Ding, Ding; Qin, Xian; Maturi, Fernando E.; Lim, Winnie W. Y.; De Wen Soh,; J. Rocha; Zhigao Yi; Xiaogang Liu; Carlos, Luís D.
Published in: The Journal of Physical Chemistry Letters, Issue 16, 2020, Page(s) 6704-6711, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.5281/zenodo.5701318

Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules

Author(s): Zamora-Perez, P., Xiao, C., Sanles-Sobrido,M., Rovira-Esteva, M., Conesa, J.J., Mulens-Arias, V., Jaque, D., & Rivera-Gil, P.
Published in: Acta Biomaterialia, 2022, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.01.052

The near‐infrared autofluorescence fingerprint of the brain

Author(s): José Lifante, Blanca Rosal, Irene Chaves‐Coira, Nuria Fernández, Daniel Jaque, Erving Ximendes
Published in: Journal of Biophotonics, Issue e202000154, 2020, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202000154

The Thermodynamics of Medial Vascular Calcification

Author(s): Ángel Millán, Peter Lanzer, Víctor Sorribas
Published in: Frontiers in Cell and Development Biology, Issue 9, 2021, Page(s) 633465, ISSN 2296-634X
Publisher: Frontiers Media
DOI: 10.3389/fcell.2021.633465

Perspectives for Ag2S NIR-II nanoparticles in biomedicine: from imaging to multifunctionality

Author(s): Shen Y., Lifante J., Ximendes E., Santos H. D. A, Ruiz D., . Juárez, B. H., Gutiérrez, I. Z., Vera, V. T., Retama J. R., Rodríguez E.M., Ortgies, D.H., Jaque, D., Benayas, A. & del Rosal, B.
Published in: Nanoscale, Issue 11, 2019, Page(s) 19251, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr05733a

The influence of the Er3+ dopant concentration in LaPO4:Nd3+, Er3+ on thermometric properties of ratiometric and kinetic-based luminescent thermometers operating in NIR II and NIR III optical windows

Author(s): Maciejewska, K., Bednarkiewicz, A. & Marciniak, L.
Published in: Physica B: Condensed Matter, Issue 620, 2021, Page(s) 413247, ISSN 0921-4526
Publisher: Elsevier BV
DOI: 10.1016/j.physb.2021.413247

Thermal Properties of Lipid Bilayers Determined Using Upconversion Nanothermometry

Author(s): Ana R. N. Bastos; Carlos D. S. Brites; Paola A. Rojas‐Gutierrez; Christine DeWolf; Rute A. S. Ferreira; John A. Capobianco; Luís D. Carlos
Published in: Advanced Functional Materials, Issue 29, 2019, Page(s) 1905474, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.5281/zenodo.3597416

Instantaneous In Vivo Imaging of Acute Myocardial Infarct by NIR‐II Luminescent Nanodots

Author(s): Sergio Mateos, José Lifante, Chunyan Li, Erving C. Ximendes, Tamara Muñoz‐Ortiz, Jingke Yao, María Fuente‐Fernández, Ángel Luis García Villalón, Miriam Granado, Irene Zabala Gutierrez, Jorge Rubio‐Retama, Daniel Jaque, Dirk H. Ortgies, Nuria Fernández
Published in: Small, Issue 16/29, 2020, Page(s) 1907171, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201907171

Endocytosis-driven gold nanoparticle fractal rearrangement in cells and its influence on photothermal conversion

Author(s): Mulens-Arias, V., Balfourier, A., Nicolás-Boluda, A., Carn, F. & Gazeau, F.
Published in: Nanoscale, Issue 12, 2020, Page(s) 21832–21849, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr05886f

From quencher to potent activator – Multimodal luminescence thermometry with Fe3+ in the oxides MAl4O7 (M = Ca, Sr, Ba)

Author(s): Kniec, Karolina; Piotrowski, Wojciech; Ledwa, Karolina; Suta, Markus; Carlos, Luís D.; Marciniak, Lukasz
Published in: Journal of Materials Chemistry C, Issue 30, 2021, Page(s) 2003101, ISSN 2050-7526
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tc01272j

All near-infrared multiparametric luminescence thermometry using Er3+, Yb3+-doped YAG nanoparticles

Author(s): Periša, Jovana; Ristić, Zoran; Piotrowski, Wojciech; Atić, Željka; Marciniak, Lukasz; Dramićanin, Miroslav D.
Published in: RSC Advances, Issue 11, 2021, Page(s) 15933-15942, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ra01647d

Gold-based therapy: From past to present.

Author(s): Alice Balfourier; Jelena Kolosnjaj-Tabi; Nathalie Luciani; Florent Carn; Florence Gazeau
Published in: PNAS, Issue 117, 2020, Page(s) 22639-22648, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2007285117

[Ga3+8Sm3+2, Ga3+8Tb3+2] Metallacrowns are Highly Promising Ratiometric Luminescent Molecular Nanothermometers Operating at Physiologically Relevant Temperatures

Author(s): Elvin V. Salerno; Justyna Zeler; Svetlana V. Eliseeva; Miguel A. Hernández-Rodríguez; Albano N. Carneiro Neto; Stéphane Petoud; Vincent L. Pecoraro; Luís D. Carlos
Published in: Chemical-A European Journal, Issue 26, 2020, Page(s) 13792-13796, ISSN 1521-3765
Publisher: Wiley
DOI: 10.5281/zenodo.6343837

10-Fold Quantum Yield Improvement of Ag2S Nanoparticles by Fine Compositional Tuning

Author(s): Alicia Ortega-Rodríguez; Alicia Ortega-Rodríguez; Yingli Shen; Irene Zabala Gutierrez; Harrison D. A. Santos; Vivian Torres Vera; Erving Ximendes; Gonzalo Villaverde; José Lifante; Christoph Gerke; Nuria Fernández; Oscar G. Calderón; Sonia Melle; Jose Marques-Hueso; Diego Mendez-Gonzalez; Marco Laurenti; Callum M. S. Jones; Juan Manuel López-Romero; Rafael Contreras-Cáceres; Daniel Jaque; J
Published in: ACS Applied Materials and Interfaces, Issue 12, 2020, Page(s) 12500-12509, ISSN 1944-8252
Publisher: American Chemical Society
DOI: 10.1021/acsami.9b22827

Making Nd<sup>3+</sup> a Sensitive Luminescent Thermometer for Physiological Temperatures—An Account of Pitfalls in Boltzmann Thermometry

Author(s): Markus Suta; Željka Antić; Vesna Ðorđević; Sanja Kuzman; Miroslav D. Dramićanin; Andries Meijerink
Published in: Nanomaterials, Issue 10 (3), 2020, Page(s) 543, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10030543

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