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Nanoparticles-based 2D thermal bioimaging technologies

Objective

Temperature measurements are crucial in countless technological developments, accounting for 80% of the sensor market throughout the world. The pitfalls of temperature readouts at the biomedical battleground are mostly represented by the currently achievable spatial resolution. To address key issues, such as intracellular temperature fluctuations and in vivo thermal transients, a technique able to go clearly below 1 μm is highly and urgently needed, as the traditional contact-based sensors and near infrared thermometers are not suitable for measurements at that tight spatial range. To overcome these limitations requires a non-contact thermometry approach granted with sub-micrometer resolution, also providing real-time high relative thermal sensitivity values.

The goal of NanoTBTech is to develop a 2-D thermal bioimaging technology featuring sub-microscale resolution, based on nanothermometers and heater-thermometer nanostructures. We will design, synthetize, and bio-functionalize nontoxic luminescent nanostructures, operating essentially beyond 1000 nm, for in vivo nanothermometry and nanoheating. Furthermore, to monitor the temperature-dependent nanostructures’ luminescence we will develop a novel imaging system. The effective delivery of that major advance in 2-D thermal bioimaging will be implemented through two impactful biomedical showcases: highly spatially-modulated intracellular magnetic/optical hyperthermia and in vivo detection and tracking of cancer.

In the long-term, we foresee our technology having a broad impact on non-invasive clinical imaging and theranostics. For instance, the accurate measurement of temperature gradients´ sources will be an invaluable tool for real-time control of thermal therapies, thus making them harmless for the patient. Multiple conceptual breakthroughs can be further envisaged from the proposed 2D-thermal imaging system, credibly spreading its impact towards non-biomedical technological areas.

Call for proposal

H2020-FETOPEN-1-2016-2017
See other projects for this call

Coordinator

UNIVERSIDADE DE AVEIRO
Address
Campus Universitário De Santiago
3810-193 Aveiro
Portugal
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 508 060

Participants (8)

FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL
Spain
EU contribution
€ 450 250
Address
Ctra Colmenar Vlejo Km 9.100
28034 Madrid
Activity type
Other
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 467 025
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 354 432,50
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
INSTITUT ZA NUKLEARNE NAUKE VINCA INSTITUT OD NACIONALNOG ZNACAJA ZA REPUBLIKU SRBIJU, UNIVERZITET U BEGRADU
Serbia
EU contribution
€ 258 750
Address
Mihajla Petrovica Alasa 12
11307 Vinca Beograd
Activity type
Other
INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH IM. WLODZIMIERZA TRZEBIATOWSKIEGO POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 277 375
Address
Ul Okolna 2
50422 Wroclaw
Activity type
Research Organisations
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 234 375
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
NANOIMMUNOTECH SL
Spain
EU contribution
€ 205 477,50
Address
Edificio Citexvi C Fonte Das Abelle Sn Campus Universitario De Vigo
36310 Vigo Pontevedra
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOSPACE LAB
France
EU contribution
€ 243 737,50
Address
11 Rue De Chenival
95690 Nesles-la-vallee
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)