Revealing the Epigenetic Regulatory Network with Single-Molecule Precision

Project Information

SM-Epigen

Grant agreement ID: 801655

DOI

10.3030/801655

Project closed

EC signature date 31 October 2018

Start date 1 November 2018

End date 31 October 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

It's all in the combination: decoding the epigenome for cancer research and diagnostics

Author(s): Noa Furth, Efrat Shema
Published in: Current opinion in genetics & development, 2022, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2022.101899

Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics

Author(s): Vadim Fedyuk, Nir Erez, Noa Furth, Olga Beresh, Ekaterina N Andreishcheva, Abhijeet Shinde, Daniel Jones, Barak Bar Zakai, Yael Mavor, Tamar Peretz,Ayala Hubert, Jonathan Cohen, Azzam Salah, Mark Temper, Albert Grinshpun, Myriam Maoz, Aviad Zick, Guy Ron, Efrat Shema
Published in: Nature Biotechnology, 2022, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01447-3

Intratumoral heterogeneity in cancer progression and response to immunotherapy

Author(s): Ilio Vitale, Efrat Shema, Sherene Loi, Lorenzo Galluzzi
Published in: Nature Medicine, 2021, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01233-9

PRC2-independent actions of H3. 3K27M in embryonic stem cell differentiation

Author(s): Lea R Z Cohen, Binyamin Kaffe, Eden Deri, Chen Leibson, Malka Nissim-Rafinia, Moria Maman, Nofar Harpaz, Guy Ron, Efrat Shema, Eran Meshorer
Published in: Nucleic Acids Research, 2023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac800

H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

Author(s): Noa Furth, Danielle Algranati, Bareket Dassa, Olga Beresh, Vadim Fedyuk, Natasha Morris, Lawryn H. Kasper, Dan Jones, Michelle Monje, Suzanne J. Baker, Efrat Shema
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110836

Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

Author(s): Nofar Harpaz, Tamir Mittelman, Olga Beresh, Ofir Griess, Noa Furth, Tomer-Meir Salame, Roni Oren, Liat Fellus-Alyagor, Alon Harmelin, Sanda Alexandrescu, Joana Graca Marques, Mariella G Filbin, Guy Ron, Efrat Shema
Published in: Molecular Cell, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.05.023

Non-peer reviewed articles (1)

A single-molecule liquid biopsy for cancer diagnosis

Author(s): Efrat Shema
Published in: Nature Reviews Cancer, 2023, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-023-00563-9