Study of telomere function in germ cells, relevant to the regulations of homologous recombination and telomere length maintenance across generations

Project Information

Meiotic telomere

Grant agreement ID: 801659

DOI

10.3030/801659

Project closed

EC signature date 17 October 2018

Start date 1 January 2019

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

GOETEBORGS UNIVERSITET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2

Author(s): Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanović, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernández-Hernández, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46718-6

BRCA2 in mammalian meiosis

Author(s): Jingjing Zhang; Jayakrishnan Nandakumar; Hiroki Shibuya
Published in: Trends in Cell Biology, Issue 1, 2022, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2021.09.003

Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites

Author(s): Devon F. Pendlebury, Jingjing Zhang, Ritvija Agrawal, Hiroki Shibuya, Jayakrishnan Nandakumar
Published in: Nature Structural & Molecular Biology, Issue 28/8, 2021, Page(s) 671-680, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00635-0

The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

Author(s): Ritvija Agrawal; John P Gillies; Juliana L Zang; Jingjing Zhang; Sharon R Garrott; Hiroki Shibuya; Jayakrishnan Nandakumar; Morgan E DeSantis
Published in: Crossref, Issue 3, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.78201

The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

Author(s): Jingjing Zhang, Manickam Gurusaran, Yasuhiro Fujiwara, Kexin Zhang, Meriem Echbarthi, Egor Vorontsov, Rui Guo, Devon F. Pendlebury, Intekhab Alam, Gabriel Livera, Martini Emmanuelle, P. Jeremy Wang, Jayakrishnan Nandakumar, Owen R. Davies, Hiroki Shibuya
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15954-x

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.

Author(s): He S, Gillies JP, Zang JL, Córdoba-Beldad CM, Yamamoto I, Fujiwara Y, Grantham J, DeSantis ME, Shibuya H
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37370-7

The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I

Author(s): Kexin Zhang; Agata Tarczykowska; Deepesh Kumar Gupta; Devon F. Pendlebury; Cassandra Zuckerman; Jayakrishnan Nandakumar; Hiroki Shibuya
Published in: Cell Reports, Vol 38, Iss 4, Pp 110289- (2022), Issue 1, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110289