DNA-protein crosslinks: endogenous origins and cellular responses.

Project Information

DNAProteinCrosslinks

Grant agreement ID: 801750

DOI

10.3030/801750

Project closed

EC signature date 24 October 2018

Start date 1 February 2019

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 497 375,00

EU contribution

€ 1 497 375,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN

Author(s): Shubo Zhao, Anja Kieser, Hao-Yi Li, Hannah K Reinking, Pedro Weickert, Simon Euteneuer, Denitsa Yaneva, Aleida C Acampora, Maximilian J Götz, Regina Feederle, Julian Stingele
Published in: Nucleic Acids Research, Issue 49/2, 2020, Page(s) 902-915, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1224

RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks

Author(s): Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J
Published in: Molecular Cell, 2023, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.10.012

SPRTN patient variants cause global-genome DNA-protein crosslink repair defects

Author(s): Pedro Weickert, Hao-Yi Li, Maximilian J. Götz, Sophie Dürauer, Denitsa Yaneva, Shubo Zhao, Jacqueline Cordes, Aleida C. Acampora, Ignasi Forne, Axel Imhof & Julian Stingele
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-35988-1

Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB

Author(s): Carnie CJ, Acampora AC, Bader AS, Erdenebat C, Zhao S, Bitensky E, van den Heuvel D, Parnas A, Gupta V, D'Alessandro G, Sczaniecka-Clift M, Weickert P, Aygenli F, Götz MJ, Cordes J, Esain-Garcia I, Melidis L, Wondergem AP, Lam S, Robles MS, Balasubramanian S , Adar S, Luijsterburg MS, Jackson SP, Stingele J
Published in: Nature Cell Biology, 2024, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01391-1

The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair

Author(s): Denitsa Yaneva, Justin L Sparks, Maximilian Donsbach, Shubo Zhao, Pedro Weickert, Rachel Bezalel-Buch, Julian Stingele, Johannes C Walter
Published in: Molecular Cell, 2023, ISSN 1097-4164
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.12.005

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease

Author(s): Hannah K. Reinking, Hyun-Seo Kang, Maximilian J. Götz, Hao-Yi Li, Anja Kieser, Shubo Zhao, Aleida C. Acampora, Pedro Weickert, Evelyn Fessler, Lucas T. Jae, Michael Sattler, Julian Stingele
Published in: Molecular Cell, 2020, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.08.003

Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS

Author(s): Carnie CJ, Götz MJ, Palma-Chaundler CS, Weickert P, Wanders A, Serrano-Benitez A, Li HY, Gupta V, Awwad SW, Blum CJ, Sczaniecka-Clift M, Cordes J, Zagnoli-Vieira G, D'Alessandro G, Richards SL, Gueorguieva N, Lam S, Beli P, Stingele J, Jackson SP
Published in: The EMBO Journal, 2024, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.1038/s44318-024-00108-2

A non-proteolytic release mechanism for HMCES-DNA-protein crosslinks

Author(s): Maximilian Donsbach, Sophie Dürauer, Florian Grünert, Kha T Nguyen, Richa Nigam, Denitsa Yaneva Pedro Weickert, Rachel Bezalel-Buch, Daniel R Semlow, Julian Stingele
Published in: The EMBO Journal, 2023, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022113360