Skip to main content

DNA-protein crosslinks: endogenous origins and cellular responses.

Project description

DNA–protein interactions: new culprits for cancer formation?

Interactions between DNA and proteins are central for many biological functions including transcription and cell division. However, these interactions are transient and dynamic in nature. Permanent covalent protein linkages with DNA molecules – known as DNA–protein crosslinks (DPCs) – interfere with the physiological role of DNA and proteins and lead to genomic instability. The EU-funded DNAProteinCrosslinks project will investigate the mechanism of DPC repair, which is essential for cell viability and tumour suppression. The project will provide fundamental insight into DPC detection and quality control in cells, offering at the same time a new perspective on pathways causing genomic instability.

Host institution

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Net EU contribution
€ 1 497 375,00
Address
Geschwister Scholl Platz 1
80539 Muenchen
Germany

See on map

Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 1 497 375,00
Address
Geschwister Scholl Platz 1
80539 Muenchen

See on map

Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00