Resurrecting LUCA - Engineering of RNA-encoded Cellular Life Using Dual Evolution and Intergenomic Transplantation

Project Information

RiboLife

Grant agreement ID: 802000

DOI

10.3030/802000

Project closed

EC signature date 14 August 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

TECHNISCHE UNIVERSITAT DORTMUND
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

Open Research Data Pilot

Publications

Peer reviewed articles (14)

Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment

Author(s): Annalena Salditt, Leonie Karr, Elia Salibi, Kristian Le Vay, Dieter Braun, Hannes Mutschler
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37206-4

Enhanced Ribozyme-Catalyzed Recombination and Oligonucleotide Assembly in Peptide-RNA Condensates.

Author(s): Kristian Le Vay; Emilie Yeonwha Song; Basusree Ghosh; T.‐Y. Dora Tang; Hannes Mutschler
Published in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202109267

Complete RNA replication cycles in a Hadean microcompartment

Author(s): Annalena Salditt; Leonie Karr; Elia Salibi; Kristian Le Vay; Dieter Braun; Hannes Mutschler
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-1989787/v1

The Long Road to a Synthetic Self-Replicating Central Dogma

Author(s): Jacopo De Capitani; Hannes Mutschler
Published in: Biochemistry, 2023, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.3c00023

Design principles and applications of synthetic self‐replicating <scp>RNAs</scp>

Author(s): Alexander Wagner; Hannes Mutschler
Published in: WIREs RNA, 2023, ISSN 1757-7012
Publisher: Wiley-VCH
DOI: 10.1002/wrna.1803

Heat flows in rock cracks naturally optimize salt compositions for ribozymes

Author(s): T. Matreux, K. Le Vay, A. Schmid, P. Aikkila, L. Belohlavek, A. Z. Çalışkanoğlu, E. Salibi, A. Kühnlein, C. Springsklee, B. Scheu, D. B. Dingwell, D. Braun, H. Mutschler, C. B. Mast
Published in: Nature Chemistry, Issue 13, 2021, Page(s) 1038-1045, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-021-00772-5

In vitro characterisation of the MS2 RNA polymerase complex reveals host factors that modulate emesviral replicase activity

Author(s): A Wagner, LI Weise, H Mutschler
Published in: Communications Biology, 2022, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-022-03178-2

Intracellular Expression of a Fluorogenic DNA Aptamer Using Retron Eco2

Author(s): Mahesh A Vibhute, Corbin Machatzke, Katrin Bigler, Saskia Krümpel, Daniel Summerer, Hannes Mutschler
Published in: eLife, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.99554.1

Design of Novel Synthetic RNA Replicons Based on <i>Emesvirus zinderi</i>

Author(s): Alexander Wagner, Hannes Mutschler
Published in: ACS Synthetic Biology, Issue 13, 2024, Page(s) 1773-1780, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.4c00097

Regulating Nucleic Acid Catalysis Using Active Droplets

Author(s): Anna‐Lena Holtmannspötter, Corbin Machatzke, Christian Begemann, Elia Salibi, Carsten Donau, Fabian Späth, Job Boekhoven, Hannes Mutschler
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202412534

Periodic temperature changes drive the proliferation of self-replicating RNAs in vesicle populations

Author(s): Elia Salibi, Benedikt Peter, Petra Schwille, Hannes Mutschler
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36940-z

A Primer on Building Life‐Like Systems

Author(s): Hannes Mutschler; Mahesh A. Vibhute
Published in: ChemSystemsChem, 2023, ISSN 2570-4206
Publisher: Wiley-VCH
DOI: 10.1002/syst.202200033

Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning

Author(s): Juan M. Iglesias-Artola; Björn Drobot; Mrityunjoy Kar; Anatol W. Fritsch; Hannes Mutschler; T.-Y. Dora Tang; Moritz Kreysing
Published in: Nature Chemistry, 2022, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-022-00890-8

Engineering a Synthetic RNA Segregation System

Author(s): Daniel Hürtgen, Judita Mascarenhas, Mahesh A. Vibhute, Laura I. Weise, Viktoria S. Mayr, Victor Sourjik, Hannes Mutschler
Published in: ChemSystemsChem, 2023, ISSN 2570-4206
Publisher: Wiley-VCH
DOI: 10.1002/syst.202200028

Thesis and dissertations (2)

Towards the design and construction of self-replicating RNA nanostructures

Author(s): David Rubert
Published in: 2024
Publisher: Eldorado TU Dortmund
DOI: 10.17877/de290r-24469

Reprogramming Emesvirus zinderi: an approach to changing an RNA virus's behaviour

Author(s): Alexander Wagner
Published in: 2022
Publisher: LMU Elektronische Hochschulschriften
DOI: 10.5282/edoc.30574